Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional repressor Mce3R

Gene

mce3R

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mce3R represses the transcription of mce3 operon and downregulates its own expression, but does not affect the transcription of mce1, mce2 and mce4 operons.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi36 – 55H-T-H motifPROSITE-ProRule annotationAdd BLAST20
DNA bindingi240 – 259H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: MTBBASE
  • transcription factor activity, sequence-specific DNA binding Source: MTBBASE
  • transcription regulatory region sequence-specific DNA binding Source: GO_Central

GO - Biological processi

  • growth Source: MTBBASE
  • negative regulation of transcription, DNA-templated Source: MTBBASE
  • regulation of lipid metabolic process Source: MTBBASE
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6162-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor Mce3R1 Publication
Alternative name(s):
TetR family transcriptional regulator1 Publication
Gene namesi
Name:mce3R1 Publication
Ordered Locus Names:Rv1963c
ORF Names:LH57_10685Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1963c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene result in a significant increase in the expression of mce3 either in vitro or in a murine cell macrophages line.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004385361 – 406Transcriptional repressor Mce3RAdd BLAST406

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1963c.

Structurei

3D structure databases

SMRiP95251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 73HTH tetR-type 1PROSITE-ProRule annotationAdd BLAST61
Domaini217 – 277HTH tetR-type 2PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 2 HTH tetR-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000049229.
OMAiVEGHVRI.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 2 hits.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50977. HTH_TETR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P95251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVAQPVRR RPKDRKKQIL DQAVGLFIER GFHSVKLEDI AEAAGVTARA
60 70 80 90 100
LYRHYDNKQA LLAEAIRTGQ DQYQSARRLT EGETEPTPRP LNADLEDLIA
110 120 130 140 150
AAVASRALTV LWQREARYLN EDDRTAVRRR INAIVAGMRD SVLLEVPDLS
160 170 180 190 200
PQHSELRAWA VSSTLTSLGR HSLSLPGEEL KKLLYQACMA AARTPPVCEL
210 220 230 240 250
PPLPAGDAAR DEADVLFSRY ETLLAAGARL FRAQGYPAVN TSEIGKGAGI
260 270 280 290 300
AGPGLYRSFS SKQAILDALI RRLDEWRCLE CIRALRANQQ AAQRLRGLVQ
310 320 330 340 350
GHVRISLDAP DLVAVSVTEL SHASVEVRDG YLRNQGDREA VWIDLIGKLV
360 370 380 390 400
PATSVAQGRL LVAAAISFIE DVARTWHLTR YAGVADEISG LALAILTSGA

GNLLRA
Length:406
Mass (Da):44,342
Last modified:August 1, 1998 - v2
Checksum:iA268EDF92AD8E61B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14708.1.
AL123456 Genomic DNA. Translation: CCP44732.1.
RefSeqiNP_216479.1. NC_000962.3.
WP_003409919.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR14708; AIR14708; LH57_10685.
CCP44732; CCP44732; Rv1963c.
GeneIDi885950.
KEGGimtu:Rv1963c.
mtv:RVBD_1963c.
PATRICi18126198. VBIMycTub22151_2211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14708.1.
AL123456 Genomic DNA. Translation: CCP44732.1.
RefSeqiNP_216479.1. NC_000962.3.
WP_003409919.1. NZ_KK339370.1.

3D structure databases

SMRiP95251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1963c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR14708; AIR14708; LH57_10685.
CCP44732; CCP44732; Rv1963c.
GeneIDi885950.
KEGGimtu:Rv1963c.
mtv:RVBD_1963c.
PATRICi18126198. VBIMycTub22151_2211.

Organism-specific databases

TubercuListiRv1963c.

Phylogenomic databases

HOGENOMiHOG000049229.
OMAiVEGHVRI.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6162-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.357.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
[Graphical view]
PfamiPF00440. TetR_N. 2 hits.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50977. HTH_TETR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCE3R_MYCTU
AccessioniPrimary (citable) accession number: P95251
Secondary accession number(s): F2GGQ2, I6Y7Z5, Q7D7P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.