P95199 (P95199_MYCTU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
O-succinylhomoserine sulfhydrylase EMBL AAK44624.1
EC=4.2.99.- EMBL AAK44624.1

Submitted name:
PROBABLE O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ (OSH SULFHYDRYLASE) EMBL CAB06597.1
EC=4.2.99.- EMBL CAB06597.1

Gene names

Name:	metZ EMBL CAB06597.1
Ordered Locus Names:	MT0402, Rv0391

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the trans-sulfuration enzymes family. RuleBase RU004079

Ontologies

Keywords
Molecular function	Lyase EMBL CAB06597.1
Technical term	3D-structure PDB 3NDN Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	homocysteine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	lyase activity Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	P95199 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: E5C405B25297D04B	FASTA	406	43,345
	10 20 30 40 50 60 MTDESSVRTP KALPDGVSQA TVGVRGGMLR SGFEETAEAM YLTSGYVYGS AAVAEKSFAG 70 80 90 100 110 120 ELDHYVYSRY GNPTVSVFEE RLRLIEGAPA AFATASGMAA VFTSLGALLG AGDRLVAARS 130 140 150 160 170 180 LFGSCFVVCS EILPRWGVQT VFVDGDDLSQ WERALSVPTQ AVFFETPSNP MQSLVDIAAV 190 200 210 220 230 240 TELAHAAGAK VVLDNVFATP LLQQGFPLGV DVVVYSGTKH IDGQGRVLGG AILGDREYID 250 260 270 280 290 300 GPVQKLMRHT GPAMSAFNAW VLLKGLETLA IRVQHSNASA QRIAEFLNGH PSVRWVRYPY 310 320 330 340 350 360 LPSHPQYDLA KRQMSGGGTV VTFALDCPED VAKQRAFEVL DKMRLIDISN NLGDAKSLVT 370 380 390 400 HPATTTHRAM GPEGRAAIGL GDGVVRISVG LEDTDDLIAD IDRALS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L., Delcher A., Utterback T. , Weidman J., Khouri H., Gill J., Mikula A., Bishai W., Jacobs Jr W.R. Jr, Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Crystal structure of O-succinylhomoserine sulfhydrylase from Mycobacterium tuberculosis covalently bound to pyridoxal-5-phosphate." Seattle Structural Genomics Center for Infectious Disease (SSGCID) Edwards T.E., Gardberg A.S., Sankaran B. Submitted (JUN-2010) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000516 Genomic DNA. Translation: AAK44624.1.
BX842573 Genomic DNA. Translation: CAB06597.1.

PIR

F70632.

RefSeq

NP_214905.1. NC_000962.2.
NP_334810.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3NDN	X-ray	1.85	A/B/C/D	1-406	[»]

ProteinModelPortal

P95199.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBMYCT00000001965; EBMYCP00000001965; EBMYCG00000001963.
EBMYCT00000072090; EBMYCP00000070149; EBMYCG00000072085.

GeneID

886431.
923639.

GenomeReviews

Gene locus MT0402 in contig AE000516_GR.
Gene locus Rv0391 in contig AL123456_GR.

KEGG

mtc:MT0402.
mtu:Rv0391.

PATRIC

18122600. VBIMycTub22151_0434.

TIGR

MT0402.

Organism-specific databases

TubercuList

Rv0391.

Phylogenomic databases

GeneTree

EBGT00050000016651.

HOGENOM

HBG754729.

OMA

NTKVFFL.

PhylomeDB

P95199.

ProtClustDB

PRK07810.

Family and domain databases

InterPro

IPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR006234. O-succ-hSer_sulfhydrylase.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]

Gene3D

G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.

KO

K10764.

PANTHER

PTHR11808. Cys_Met_Meta_PP. 1 hit.
PTHR11808:SF28. PTHR11808:SF28. 1 hit.

Pfam

PF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]

PIRSF

PIRSF001434. CGS. 1 hit.

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

TIGRFAMs

TIGR01325. O_suc_HS_sulf. 1 hit.

ProtoNet

Search...

Entry information

Entry name

P95199_MYCTU

Accession

Primary (citable) accession number: P95199
Secondary accession number(s): Q7D9W7

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	December 14, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)