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P95197 (P95197_MYCTU) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
PROBABLE PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 PURT (GART 2) (GAR TRANSFORMYLASE 2) (5'-PHOSPHORIBOSYLGLYCINAMIDE TRANSFORMYLASE 2) (FORMATE-DEPENDENT GAR TRANSFORMYLASE) EMBL CAB06595.1
EC=2.1.2.- EMBL CAB06595.1
Submitted name:
Phosphoribosylglycinamide formyltransferase 2 EMBL AAK44623.1
EC=2.1.2.- EMBL AAK44623.1
Gene names
Name:purT EMBL CAB06595.1
Ordered Locus Names:MT0401, Rv0389
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP By similarity. SAAS SAAS011054

Catalytic activity

Formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate. SAAS SAAS011054

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1. SAAS SAAS011054

Sequence similarities

Contains 1 ATP-grasp domain. SAAS SAAS003135

Sequences

Sequence LengthMass (Da)Tools
P95197 [UniParc].

Last modified August 1, 1998. Version 2.
Checksum: ED0FEDF8912DE009

FASTA41943,678
        10         20         30         40         50         60 
MIDGWTEEQH EPTVRHERPA APQDVRRVML LGSAEPSREL AIALQGLGAE VIAVDGYVGA 

        70         80         90        100        110        120 
PAHRIADQSV VVTMTDAEEL TAVIRRLQPD FLVTVTAAVS VDALDAVEQA DGECTELVPN 

       130        140        150        160        170        180 
ARAVRCTADR EGLRRLAADQ LGLPTAPFWF VGSLGELQAV AVHAGFPLLV SPVAGVAGQG 

       190        200        210        220        230        240 
SSVVAGPNEV EPAWQRAAGH QVQPQTGGVS PRVCAESVVE IEFLVTMIVV CSQGPNGPLI 

       250        260        270        280        290        300 
EFCAPIGHRD ADAGELESWQ PQKLSTAALD AAKSIAARIV KALGGRGVFG VELMINGDEV 

       310        320        330        340        350        360 
YFADVTVCPA GSAWVTVRSQ RLSVFELQAR AILGLAVDTL MISPGAARVI NPDHTAGRAA 

       370        380        390        400        410 
VGAAPPADAL TGALGVPESD VVIFGRGLGV ALATAPEVAI ARERAREVAS RLNVPDSRE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000516 Genomic DNA. Translation: AAK44623.1.
BX842573 Genomic DNA. Translation: CAB06595.1.
PIRD70632.
RefSeqNP_214903.1. NC_000962.2.
NP_334809.1. NC_002755.2.

3D structure databases

HSSPHSSP built from PDB template 1KJ8 based on UniProtKB P33221.
ProteinModelPortalP95197.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000003239; EBMYCP00000003239; EBMYCG00000003237.
EBMYCT00000072972; EBMYCP00000071031; EBMYCG00000072967.
GeneID886032.
923632.
GenomeReviewsGene locus MT0401 in contig AE000516_GR.
Gene locus Rv0389 in contig AL123456_GR.
KEGGmtc:MT0401.
mtu:Rv0389.
PATRIC18122596. VBIMycTub22151_0432.
TIGRMT0401.

Organism-specific databases

TubercuListRv0389.

Phylogenomic databases

GeneTreeEBGT00050000015722.
HOGENOMHBG516369.
OMAFGVELMV.
PhylomeDBP95197.
ProtClustDBPRK09288.

Family and domain databases

InterProIPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR013817. Pre-ATP_grasp.
IPR016185. PreATP-grasp-like.
IPR005862. PurT.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
Gene3DG3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
KOK08289.
PANTHERPTHR23047:SF2. PurT. 1 hit.
PfamPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR01142. PurT. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP95197_MYCTU
AccessionPrimary (citable) accession number: P95197
Secondary accession number(s): Q7D9W8
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: August 1, 1998
Last modified: December 14, 2011
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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