P95162 (Y1847_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative esterase Rv1847/MT1895
EC=3.1.2.-

Gene names

Ordered Locus Names:	Rv1847, MT1895
ORF Names:	MTCY359.26c

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Was identified as a high-confidence drug target.
Sequence similarities	Belongs to the thioesterase PaaI family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 140

140

Putative esterase Rv1847/MT1895

PRO_0000156683

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

140

Helix Strand Turn

Details...

Helix

16 – 21

6

Beta strand

24 – 29

6

Beta strand

32 – 39

8

Helix

41 – 43

3

Beta strand

48 – 50

3

Helix

52 – 71

20

Beta strand

79 – 89

11

Beta strand

95 – 107

13

Beta strand

109 – 119

11

Beta strand

125 – 136

12

Sequences

	Sequence		Length	Mass (Da)
	P95162 [UniParc]. Last modified July 1, 1997. Version 2. Checksum: 6874C72A57095635	FASTA	140	15,098
	10 20 30 40 50 60 MQPSPDSPAP LNVTVPFDSE LGLQFTELGP DGARAQLDVR PKLLQLTGVV HGGVYCAMIE 70 80 90 100 110 120 SIASMAAFAW LNSHGEGGSV VGVNNNTDFV RSISSGMVYG TAEPLHRGRR QQLWLVTITD 130 140 DTDRVVARGQ VRLQNLEARP

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis." Raman K., Yeturu K., Chandra N. BMC Syst. Biol. 2:109-109(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BX842578 Genomic DNA. Translation: CAB06140.1.
AE000516 Genomic DNA. Translation: AAK46166.1.
AL123456 Genomic DNA. Translation: CCP44613.1.

PIR

G70664.

RefSeq

NP_216363.1. NC_000962.3.
NP_336352.1. NC_002755.2.
YP_006515247.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3S4K	X-ray	1.70	A/B	1-140	[»]

ProteinModelPortal

P95162.

SMR

P95162. Positions 15-140.

ModBase

Search...

Protein-protein interaction databases

STRING

83332.Rv1847.

Proteomic databases

PRIDE

P95162.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAK46166; AAK46166; MT1895.

GeneID

13316638.
885734.
923717.

KEGG

mtc:MT1895.
mtu:Rv1847.
mtv:RVBD_1847.

PATRIC

18125931. VBIMycTub22151_2078.

Organism-specific databases

TubercuList

Rv1847.

Phylogenomic databases

eggNOG

COG2050.

HOGENOM

HOG000066991.

OMA

HVVGVNN.

ProtClustDB

CLSK871972.

Family and domain databases

InterPro

IPR003736. PAAI_dom.
IPR006683. Thioestr_supf.
[Graphical view]

Pfam

PF03061. 4HBT. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00369. unchar_dom_1. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Y1847_MYCTU

Accession

Primary (citable) accession number: P95162
Secondary accession number(s): L0T825

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	July 1, 1997
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program