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Protein
Submitted name:

Probable reductase

Gene

Rv1869c

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6064-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable reductaseImported
Submitted name:
Pyridine nucleotide-disulfide oxidoreductaseImported
Gene namesi
Ordered Locus Names:Rv1869cImported
ORF Names:LH57_10185Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1869c.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1869c.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 304FAD/NAD-binding_domInterPro annotationAdd BLAST298
Domaini326 – 408Reductase_CInterPro annotationAdd BLAST83

Phylogenomic databases

eggNOGiENOG4107SC2. Bacteria.
ENOG410Y3KQ. LUCA.
HOGENOMiHOG000276711.
KOiK00529.
OMAiHAGFQVA.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR028202. Reductase_C.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF14759. Reductase_C. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55424. SSF55424. 1 hit.

Sequencei

Sequence statusi: Complete.

P95146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTTFVIV GGGLAGAKAV EALRRSDFGG RIILFGDEEH LPYDRPPLSK
60 70 80 90 100
EFLAGKKSLS DFTIQTSDWY RDHDVDVRLG VRVSSLDRSA HTVELPDGAA
110 120 130 140 150
VRYDKLLLAT GSAPRRPPIP GSDAAGVHYL RSYNDAVALN SVLVQGSSLA
160 170 180 190 200
VVGAGWIGLE VAASARQRGV DVTVVETAIQ PLLAALGEAV GKVFADLHRD
210 220 230 240 250
QGVDLRLQTQ LEEITAADGK ATGLKMRDGS TVAADAVLVA VGAKPNVELA
260 270 280 290 300
QQAGLAMGEG GVLVDASLRT SDPDIYAVGD IAAAEHPLLG TRVRTEHWAN
310 320 330 340 350
ALKQPAVAAA GMLGRPGEYA ELPYLFTDQY DLGMEYVGHA PSCDRVVFRG
360 370 380 390 400
NVAGREFLSF WLDGDSRVLA GMNVNVWDVV DDVKGLIRSG NPVDVDRLVD
410
PQWPLADLTT N
Length:411
Mass (Da):43,629
Last modified:May 1, 1997 - v1
Checksum:i26643CA800C8D879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14617.1.
AL123456 Genomic DNA. Translation: CCP44635.1.
RefSeqiNP_216385.1. NC_000962.3.
WP_003899055.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR14617; AIR14617; LH57_10185.
CCP44635; CCP44635; Rv1869c.
GeneIDi885796.
KEGGimtu:Rv1869c.
mtv:RVBD_1869c.
PATRICi18125981. VBIMycTub22151_2103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR14617.1.
AL123456 Genomic DNA. Translation: CCP44635.1.
RefSeqiNP_216385.1. NC_000962.3.
WP_003899055.1. NZ_KK339370.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1869c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR14617; AIR14617; LH57_10185.
CCP44635; CCP44635; Rv1869c.
GeneIDi885796.
KEGGimtu:Rv1869c.
mtv:RVBD_1869c.
PATRICi18125981. VBIMycTub22151_2103.

Organism-specific databases

TubercuListiRv1869c.

Phylogenomic databases

eggNOGiENOG4107SC2. Bacteria.
ENOG410Y3KQ. LUCA.
HOGENOMiHOG000276711.
KOiK00529.
OMAiHAGFQVA.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6064-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR028202. Reductase_C.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF14759. Reductase_C. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55424. SSF55424. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP95146_MYCTU
AccessioniPrimary (citable) accession number: P95146
Secondary accession number(s): F2GHS5, I6XZ69, Q7D7V8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.