Skip Header

Contribute Send feedback
Read comments (?) or add your own

P95143 (LLDD_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative L-lactate dehydrogenase [cytochrome]
EC=1.1.2.3
Gene names
Name:lldD
Synonyms:lldD2
Ordered Locus Names:Rv1872c, MT1921
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+.

Cofactor

FMN By similarity.

Miscellaneous

Was identified as a high-confidence drug target.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Putative L-lactate dehydrogenase [cytochrome]
PRO_0000390893

Regions

Domain29 – 406378FMN hydroxy acid dehydrogenase
Nucleotide binding332 – 35625FMN By similarity

Sites

Active site3011Proton acceptor By similarity
Binding site551Substrate Potential
Binding site1371FMN By similarity
Binding site1591FMN By similarity
Binding site1611Substrate By similarity
Binding site1871FMN By similarity
Binding site1961Substrate By similarity
Binding site2771FMN By similarity
Binding site3041Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
P95143 [UniParc].

Last modified August 1, 1998. Version 2.
Checksum: 2EA6FA4B2B89C366

FASTA41445,342
        10         20         30         40         50         60 
MAVNRRVPRV RDLAPLLQFN RPQFDTSKRR LGAALTIQDL RRIAKRRTPR AAFDYADGGA 

        70         80         90        100        110        120 
EDELSIARAR QGFRDIEFHP TILRDVTTVC AGWNVLGQPT VLPFGIAPTG FTRLMHTEGE 

       130        140        150        160        170        180 
IAGARAAAAA GIPFSLSTLA TCAIEDLVIA VPQGRKWFQL YMWRDRDRSM ALVRRVAAAG 

       190        200        210        220        230        240 
FDTMLVTVDV PVAGARLRDV RNGMSIPPAL TLRTVLDAMG HPRWWFDLLT TEPLAFASLD 

       250        260        270        280        290        300 
RWPGTVGEYL NTVFDPSLTF DDLAWIKSQW PGKLVVKGIQ TLDDARAVVD RGVDGIVLSN 

       310        320        330        340        350        360 
HGGRQLDRAP VPFHLLPHVA RELGKHTEIL VDTGIMSGAD IVAAIALGAR CTLIGRAYLY 

       370        380        390        400        410 
GLMAGGEAGV NRAIEILQTG VIRTMRLLGV TCLEELSPRH VTQLRRLGPI GAPT

« Hide

References

[1]"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. expand/collapse author list , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.
Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.
[2]"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. expand/collapse author list , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.
[3]"targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis."
Raman K., Yeturu K., Chandra N.
BMC Syst. Biol. 2:109-109(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842578 Genomic DNA. Translation: CAB06144.1.
AE000516 Genomic DNA. Translation: AAK46192.1.
AL123456 Genomic DNA. Translation: CCP44638.1.
PIRH70667.
RefSeqNP_216388.1. NC_000962.3.
NP_336378.1. NC_002755.2.
YP_006515272.1. NC_018143.1.

3D structure databases

HSSPHSSP built from PDB template 1AL8 based on UniProtKB P05414.
ProteinModelPortalP95143.
SMRP95143. Positions 35-401.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv1872c.

Proteomic databases

PRIDEP95143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK46192; AAK46192; MT1921.
GeneID13316663.
885754.
923667.
KEGGmtc:MT1921.
mtu:Rv1872c.
mtv:RVBD_1872c.
PATRIC18125987. VBIMycTub22151_2106.

Organism-specific databases

TubercuListRv1872c.

Phylogenomic databases

eggNOGCOG1304.
HOGENOMHOG000217464.
KOK00101.
OMARPAWWFN.
ProtClustDBCLSK871978.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLLDD_MYCTU
AccessionPrimary (citable) accession number: P95143
Secondary accession number(s): L0T848, Q7D7V5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: August 1, 1998
Last modified: May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents