P95056 (RL16_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L16

Gene names

Name:	rplP
Ordered Locus Names:	Rv0708, MT0735
ORF Names:	MTCY210.27

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs By similarity. HAMAP MF_01342
Subunit structure	Part of the 50S ribosomal subunit.
Sequence similarities	Belongs to the ribosomal protein L16P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	growth Inferred from mutant phenotype. Source: MTBBASE translation Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from direct assay. Source: MTBBASE ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	50S ribosomal protein L16 HAMAP MF_01342		PRO_0000062138

Sequences

	Sequence		Length	Mass (Da)
	P95056 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 2C878FC597C69D0C	FASTA	138	15,692
	10 20 30 40 50 60 MLIPRKVKHR KQHHPRQRGI ASGGTTVNFG DYGIQALEHA YVTNRQIESA RIAINRHIKR 70 80 90 100 110 120 GGKVWINIFP DRPLTKKPAE TRMGSGKGSP EWWVANVKPG RVLFELSYPN EGVARAALTR 130 AIHKLPIKAR IITREEQF

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842574 Genomic DNA. Translation: CAB06432.1. AE000516 Genomic DNA. Translation: AAK44966.1.
PIR	G70642.
RefSeq	NP_215222.1. NC_000962.2. NP_335152.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P95056.
SMR	P95056. Positions 1-134.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000000956; EBMYCP00000000956; EBMYCG00000000956. EBMYCT00000069790; EBMYCP00000067849; EBMYCG00000069785.
GeneID	888377. 926025.
GenomeReviews	Gene locus MT0735 in contig AE000516_GR. Gene locus Rv0708 in contig AL123456_GR.
KEGG	mtc:MT0735. mtu:Rv0708.
PATRIC	18123347. VBIMycTub22151_0803.
TIGR	MT0735.
Organism-specific databases
TubercuList	Rv0708.
Phylogenomic databases
GeneTree	EBGT00050000016297.
HOGENOM	HBG286097.
OMA	KGSPEFW.
PhylomeDB	P95056.
ProtClustDB	PRK09203.
Family and domain databases
HAMAP	MF_01342. Ribosomal_L16. [Tree]
InterPro	IPR016180. Ribosomal_L10e/L16. IPR000114. Ribosomal_L16. IPR020798. Ribosomal_L16_CS. [Graphical view]
KO	K02878.
Pfam	PF00252. Ribosomal_L16. 1 hit. [Graphical view]
PRINTS	PR00060. RIBOSOMALL16.
SUPFAM	SSF54686. Ribosomal_L10e/L16. 1 hit.
TIGRFAMs	TIGR01164. RplP_bact. 1 hit.
PROSITE	PS00586. RIBOSOMAL_L16_1. 1 hit. PS00701. RIBOSOMAL_L16_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL16_MYCTU

Accession

Primary (citable) accession number: P95056

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1997
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program