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P95052 (RL2_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
50S ribosomal protein L2
Gene names
Name:rplB
Ordered Locus Names:Rv0704, MT0731
ORF Names:MTCY210.23
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome By similarity. HAMAP MF_01320_B

Subunit structure

Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome By similarity.

Sequence similarities

Belongs to the ribosomal protein L2P family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 28028050S ribosomal protein L2 HAMAP MF_01320_B
PRO_0000129587

Sequences

Sequence LengthMass (Da)Tools
P95052 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 456837947E32FFBB

FASTA28030,577
        10         20         30         40         50         60 
MAIRKYKPTT PGRRGASVSD FAEITRSTPE KSLVRPLHGR GGRNAHGRIT TRHKGGGHKR 

        70         80         90        100        110        120 
AYRMIDFRRN DKDGVNAKVA HIEYDPNRTA RIALLHYLDG EKRYIIAPNG LSQGDVVESG 

       130        140        150        160        170        180 
ANADIKPGNN LPLRNIPAGT LIHAVELRPG GGAKLARSAG SSIQLLGKEA SYASLRMPSG 

       190        200        210        220        230        240 
EIRRVDVRCR ATVGEVGNAE QANINWGKAG RMRWKGKRPS VRGVVMNPVD HPHGGGEGKT 

       250        260        270        280 
SGGRHPVSPW GKPEGRTRNA NKSSNKFIVR RRRTGKKHSR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842574 Genomic DNA. Translation: CAB06467.1.
AE000516 Genomic DNA. Translation: AAK44962.1.
PIRC70642.
RefSeqNP_215218.1. NC_000962.2.
NP_335148.1. NC_002755.2.

3D structure databases

ProteinModelPortalP95052.
SMRP95052. Positions 2-271.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002534; EBMYCP00000002534; EBMYCG00000002532.
EBMYCT00000069561; EBMYCP00000067620; EBMYCG00000069556.
GeneID888341.
926021.
GenomeReviewsGene locus MT0731 in contig AE000516_GR.
Gene locus Rv0704 in contig AL123456_GR.
KEGGmtc:MT0731.
mtu:Rv0704.
PATRIC18123339. VBIMycTub22151_0799.
TIGRMT0731.

Organism-specific databases

TubercuListRv0704.

Phylogenomic databases

GeneTreeEBGT00050000016403.
HOGENOMHBG748739.
OMAQSNINWG.
PhylomeDBP95052.
ProtClustDBPRK09374.

Family and domain databases

HAMAPMF_01320_B. Ribosomal_L2_B.
[Tree]
InterProIPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR002171. Ribosomal_L2.
IPR014726. Ribosomal_L2_3.
IPR005880. Ribosomal_L2_bac-type.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014722. Transl_SH3-like_sub.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
G3DSA:2.30.30.30. Ribosomal_L2. 1 hit.
G3DSA:4.10.950.10. Ribosomal_L2. 1 hit.
KOK02886.
PANTHERPTHR13691:SF5. Ribosom_L2_bac. 1 hit.
PTHR13691. Ribosomal_L2. 1 hit.
PfamPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFPIRSF002158. Ribosomal_L2. 1 hit.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF50104. Transl_SH3_like. 1 hit.
TIGRFAMsTIGR01171. RplB_bact. 1 hit.
PROSITEPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRL2_MYCTU
AccessionPrimary (citable) accession number: P95052
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Ribosomal proteins

Ribosomal proteins families and list of entries

SIMILARITY comments

Index of protein domains and families

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