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Protein
Submitted name:

Probable fatty acid synthase Fas (Fatty acid synthetase)

Gene

fas

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • fatty acid biosynthetic process Source: GO_Central
  • growth Source: MTBBASE

Enzyme and pathway databases

BioCyciMetaCyc:G185E-6762-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable fatty acid synthase Fas (Fatty acid synthetase)Imported
Gene namesi
Name:fasImported
Ordered Locus Names:Rv2524cImported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytoplasm Source: GO_Central
  • cytosol Source: MTBBASE
  • fatty acid synthase complex Source: InterPro
  • plasma membrane Source: MTBBASE

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2011.

Interactioni

Protein-protein interaction databases

DIPiDIP-60403N.
STRINGi83332.Rv2524c.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4107RX2. Bacteria.
COG0304. LUCA.
COG0331. LUCA.
COG2030. LUCA.
COG4981. LUCA.
COG4982. LUCA.
HOGENOMiHOG000051526.
KOiK11533.
OMAiVEPIWAD.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013785. Aldolase_TIM.
IPR013565. DUF1729.
IPR003965. Fatty_acid_synthase.
IPR029069. HotDog_dom.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR016039. Thiolase-like.
PfamiView protein in Pfam
PF00698. Acyl_transf_1. 1 hit.
PF08354. DUF1729. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
PRINTSiPR01483. FASYNTHASE.
SMARTiView protein in SMART
SM00827. PKS_AT. 1 hit.
SM00825. PKS_KS. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52151. SSF52151. 5 hits.
SSF53901. SSF53901. 2 hits.
SSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

P95029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHEHDRVS ADRGGDSPHT THALVDRLMA GEPYAVAFGG QGSAWLETLE
60 70 80 90 100
ELVSATGIET ELATLVGEAE LLLDPVTDEL IVVRPIGFEP LQWVRALAAE
110 120 130 140 150
DPVPSDKHLT SAAVSVPGVL LTQIAATRAL ARQGMDLVAT PPVAMAGHSQ
160 170 180 190 200
GVLAVEALKA GGARDVELFA LAQLIGAAGT LVARRRGISV LGDRPPMVSV
210 220 230 240 250
TNADPERIGR LLDEFAQDVR TVLPPVLSIR NGRRAVVITG TPEQLSRFEL
260 270 280 290 300
YCRQISEKEE ADRKNKVRGG DVFSPVFEPV QVEVGFHTPR LSDGIDIVAG
310 320 330 340 350
WAEKAGLDVA LARELADAIL IRKVDWVDEI TRVHAAGARW ILDLGPGDIL
360 370 380 390 400
TRLTAPVIRG LGIGIVPAAT RGGQRNLFTV GATPEVARAW SSYAPTVVRL
410 420 430 440 450
PDGRVKLSTK FTRLTGRSPI LLAGMTPTTV DAKIVAAAAN AGHWAELAGG
460 470 480 490 500
GQVTEEIFGN RIEQMAGLLE PGRTYQFNAL FLDPYLWKLQ VGGKRLVQKA
510 520 530 540 550
RQSGAAIDGV VISAGIPDLD EAVELIDELG DIGISHVVFK PGTIEQIRSV
560 570 580 590 600
IRIATEVPTK PVIMHVEGGR AGGHHSWEDL DDLLLATYSE LRSRANITVC
610 620 630 640 650
VGGGIGTPRR AAEYLSGRWA QAYGFPLMPI DGILVGTAAM ATKESTTSPS
660 670 680 690 700
VKRMLVDTQG TDQWISAGKA QGGMASSRSQ LGADIHEIDN SASRCGRLLD
710 720 730 740 750
EVAGDAEAVA ERRDEIIAAM AKTAKPYFGD VADMTYLQWL RRYVELAIGE
760 770 780 790 800
GNSTADTASV GSPWLADTWR DRFEQMLQRA EARLHPQDFG PIQTLFTDAG
810 820 830 840 850
LLDNPQQAIA ALLARYPDAE TVQLHPADVP FFVTLCKTLG KPVNFVPVID
860 870 880 890 900
QDVRRWWRSD SLWQAHDARY DADAVCIIPG TASVAGITRM DEPVGELLDR
910 920 930 940 950
FEQAAIDEVL GAGVEPKDVA SRRLGRADVA GPLAVVLDAP DVRWAGRTVT
960 970 980 990 1000
NPVHRIADPA EWQVHDGPEN PRATHSSTGA RLQTHGDDVA LSVPVSGTWV
1010 1020 1030 1040 1050
DIRFTLPANT VDGGTPVIAT EDATSAMRTV LAIAAGVDSP EFLPAVANGT
1060 1070 1080 1090 1100
ATLTVDWHPE RVADHTGVTA TFGEPLAPSL TNVPDALVGP CWPAVFAAIG
1110 1120 1130 1140 1150
SAVTDTGEPV VEGLLSLVHL DHAARVVGQL PTVPAQLTVT ATAANATDTD
1160 1170 1180 1190 1200
MGRVVPVSVV VTGADGAVIA TLEERFAILG RTGSAELADP ARAGGAVSAN
1210 1220 1230 1240 1250
ATDTPRRRRR DVTITAPVDM RPFAVVSGDH NPIHTDRAAA LLAGLESPIV
1260 1270 1280 1290 1300
HGMWLSAAAQ HAVTATDGQA RPPARLVGWT ARFLGMVRPG DEVDFRVERV
1310 1320 1330 1340 1350
GIDQGAEIVD VAARVGSDLV MSASARLAAP KTVYAFPGQG IQHKGMGMEV
1360 1370 1380 1390 1400
RARSKAARKV WDTADKFTRD TLGFSVLHVV RDNPTSIIAS GVHYHHPDGV
1410 1420 1430 1440 1450
LYLTQFTQVA MATVAAAQVA EMREQGAFVE GAIACGHSVG EYTALACVTG
1460 1470 1480 1490 1500
IYQLEALLEM VFHRGSKMHD IVPRDELGRS NYRLAAIRPS QIDLDDADVP
1510 1520 1530 1540 1550
AFVAGIAEST GEFLEIVNFN LRGSQYAIAG TVRGLEALEA EVERRRELTG
1560 1570 1580 1590 1600
GRRSFILVPG IDVPFHSRVL RVGVAEFRRS LDRVMPRDAD PDLIIGRYIP
1610 1620 1630 1640 1650
NLVPRLFTLD RDFIQEIRDL VPAEPLDEIL ADYDTWLRER PREMARTVFI
1660 1670 1680 1690 1700
ELLAWQFASP VRWIETQDLL FIEEAAGGLG VERFVEIGVK SSPTVAGLAT
1710 1720 1730 1740 1750
NTLKLPEYAH STVEVLNAER DAAVLFATDT DPEPEPEEDE PVAESPAPDV
1760 1770 1780 1790 1800
VSEAAPVAPA ASSAGPRPDD LVFDAADATL ALIALSAKMR IDQIEELDSI
1810 1820 1830 1840 1850
ESITDGASSR RNQLLVDLGS ELNLGAIDGA AESDLAGLRS QVTKLARTYK
1860 1870 1880 1890 1900
PYGPVLSDAI NDQLRTVLGP SGKRPGAIAE RVKKTWELGE GWAKHVTVEV
1910 1920 1930 1940 1950
ALGTREGSSV RGGAMGHLHE GALADAASVD KVIDAAVASV AARQGVSVAL
1960 1970 1980 1990 2000
PSAGSGGGAT IDAAALSEFT DQITGREGVL ASAARLVLGQ LGLDDPVNAL
2010 2020 2030 2040 2050
PAAPDSELID LVTAELGADW PRLVAPVFDP KKAVVFDDRW ASAREDLVKL
2060 2070 2080 2090 2100
WLTDEGDIDA DWPRLAERFE GAGHVVATQA TWWQGKSLAA GRQIHASLYG
2110 2120 2130 2140 2150
RIAAGAENPE PGRYGGEVAV VTGASKGSIA ASVVARLLDG GATVIATTSK
2160 2170 2180 2190 2200
LDEERLAFYR TLYRDHARYG AALWLVAANM ASYSDVDALV EWIGTEQTES
2210 2220 2230 2240 2250
LGPQSIHIKD AQTPTLLFPF AAPRVVGDLS EAGSRAEMEM KVLLWAVQRL
2260 2270 2280 2290 2300
IGGLSTIGAE RDIASRLHVV LPGSPNRGMF GGDGAYGEAK SALDAVVSRW
2310 2320 2330 2340 2350
HAESSWAARV SLAHALIGWT RGTGLMGHND AIVAAVEEAG VTTYSTDEMA
2360 2370 2380 2390 2400
ALLLDLCDAE SKVAAARSPI KADLTGGLAE ANLDMAELAA KAREQMSAAA
2410 2420 2430 2440 2450
AVDEDAEAPG AIAALPSPPR GFTPAPPPQW DDLDVDPADL VVIVGGAEIG
2460 2470 2480 2490 2500
PYGSSRTRFE MEVENELSAA GVLELAWTTG LIRWEDDPQP GWYDTESGEM
2510 2520 2530 2540 2550
VDESELVQRY HDAVVQRVGI REFVDDGAID PDHASPLLVS VFLEKDFAFV
2560 2570 2580 2590 2600
VSSEADARAF VEFDPEHTVI RPVPDSTDWQ VIRKAGTEIR VPRKTKLSRV
2610 2620 2630 2640 2650
VGGQIPTGFD PTVWGISADM AGSIDRLAVW NMVATVDAFL SSGFSPAEVM
2660 2670 2680 2690 2700
RYVHPSLVAN TQGTGMGGGT SMQTMYHGNL LGRNKPNDIF QEVLPNIIAA
2710 2720 2730 2740 2750
HVVQSYVGSY GAMIHPVAAC ATAAVSVEEG VDKIRLGKAQ LVVAGGLDDL
2760 2770 2780 2790 2800
TLEGIIGFGD MAATADTSMM CGRGIHDSKF SRPNDRRRLG FVEAQGGGTI
2810 2820 2830 2840 2850
LLARGDLALR MGLPVLAVVA FAQSFGDGVH TSIPAPGLGA LGAGRGGKDS
2860 2870 2880 2890 2900
PLARALAKLG VAADDVAVIS KHDTSTLAND PNETELHERL ADALGRSEGA
2910 2920 2930 2940 2950
PLFVVSQKSL TGHAKGGAAV FQMMGLCQIL RDGVIPPNRS LDCVDDELAG
2960 2970 2980 2990 3000
SAHFVWVRDT LRLGGKFPLK AGMLTSLGFG HVSGLVALVH PQAFIASLDP
3010 3020 3030 3040 3050
AQRADYQRRA DARLLAGQRR LASAIAGGAP MYQRPGDRRF DHHAPERPQE
3060
ASMLLNPAAR LGDGEAYIG
Length:3,069
Mass (Da):326,255
Last modified:August 1, 1998 - v3
Checksum:i25EF022D54943D4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA. Translation: CCP45318.1.
RefSeqiNP_217040.1. NC_000962.3.
WP_003900843.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR15294; AIR15294; LH57_13830.
CCP45318; CCP45318; Rv2524c.
GeneIDi887704.
KEGGimtu:Rv2524c.
mtv:RVBD_2524c.
PATRICifig|83332.111.peg.2822.

Similar proteinsi

Entry informationi

Entry nameiP95029_MYCTU
AccessioniPrimary (citable) accession number: P95029
Secondary accession number(s): F2GH34, I6Y0Z1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: August 1, 1998
Last modified: June 7, 2017
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported