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P94958

- AMPC_MORMO

UniProt

P94958 - AMPC_MORMO

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Protein

Beta-lactamase

Gene

ampC

Organism
Morganella morganii (Proteus morganii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei169 – 1691Proton acceptorBy similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Protein family/group databases

MEROPSiS12.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Cephalosporinase
Gene namesi
Name:ampC
OrganismiMorganella morganii (Proteus morganii)
Taxonomic identifieri582 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeMorganella

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 379358Beta-lactamasePRO_0000016961Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP94958.
SMRiP94958. Positions 25-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni333 – 3353Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94958-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKSLSATLI SALLAFSAPG FSAADNVAAV VDSTIKPLMA QQDIPGMAVA
60 70 80 90 100
VSVKGKPYYF NYGFADVQAK QPVTENTLFE LGSVSKTFTG VLGAVSVAKK
110 120 130 140 150
EMTLNDPAEK YQPELALPQW KGITLLDLAT YTAGGLPLQV PDAVKSRADL
160 170 180 190 200
LHFYQQWQPS RKPGDMRLYA NSSIGLFGAL TANAAGMPYE QLLTARILAP
210 220 230 240 250
LGLSHTFITV PESAQSQYAY GYKNKKPVRV SPGQLDAESY GVKSASKDML
260 270 280 290 300
RWAEMNMEPS RAGNADLEMA MYLAQTRYYK TAAINQGLGW EMYDWPQQKD
310 320 330 340 350
MIINGVTNEV ALQPHPVTDN QVQPYNRASW VHKTGATTGF GAYVAFIPEK
360 370
QVAIVILANK NYPNTERVKA AQAILSALE
Length:379
Mass (Da):41,272
Last modified:May 1, 1997 - v1
Checksum:i2A6BA5C3B1862873
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10283 Genomic DNA. Translation: CAA71326.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10283 Genomic DNA. Translation: CAA71326.1 .

3D structure databases

ProteinModelPortali P94958.
SMRi P94958. Positions 25-379.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL5764.

Protein family/group databases

MEROPSi S12.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the gene encoding the AmpC beta-lactamase of Morganella morganii."
    Barnaud G., Arlet G., Danglot C., Philippon A.
    FEMS Microbiol. Lett. 148:15-20(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SLM01.

Entry informationi

Entry nameiAMPC_MORMO
AccessioniPrimary (citable) accession number: P94958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3