Reviewed, UniProtKB/Swiss-Prot P94958 (AMPC_MORMO)

Names and origin

Protein names

Recommended name:
    Beta-lactamase
    EC=3.5.2.6
Alternative name(s):
    Cephalosporinase

Gene names

Name:

ampC

Organism

Morganella morganii (Proteus morganii)

Taxonomic identifier

582 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Morganella

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
Catalytic activity	A beta-lactam + H2O = a substituted beta-amino acid.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the class-C beta-lactamase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Cellular component	Periplasm
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 379	358	Beta-lactamase		PRO_0000016961
Regions
	Region	333 – 335	3	Substrate binding By similarity
Sites
	Active site	83	1	Acyl-ester intermediate By similarity
	Active site	169	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P94958-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 2A6BA5C3B1862873	FASTA	379	41,272
	10 20 30 40 50 60 MKKSLSATLI SALLAFSAPG FSAADNVAAV VDSTIKPLMA QQDIPGMAVA VSVKGKPYYF 70 80 90 100 110 120 NYGFADVQAK QPVTENTLFE LGSVSKTFTG VLGAVSVAKK EMTLNDPAEK YQPELALPQW 130 140 150 160 170 180 KGITLLDLAT YTAGGLPLQV PDAVKSRADL LHFYQQWQPS RKPGDMRLYA NSSIGLFGAL 190 200 210 220 230 240 TANAAGMPYE QLLTARILAP LGLSHTFITV PESAQSQYAY GYKNKKPVRV SPGQLDAESY 250 260 270 280 290 300 GVKSASKDML RWAEMNMEPS RAGNADLEMA MYLAQTRYYK TAAINQGLGW EMYDWPQQKD 310 320 330 340 350 360 MIINGVTNEV ALQPHPVTDN QVQPYNRASW VHKTGATTGF GAYVAFIPEK QVAIVILANK 370 NYPNTERVKA AQAILSALE

References

[1]	"Cloning and sequencing of the gene encoding the AmpC beta-lactamase of Morganella morganii." Barnaud G., Arlet G., Danglot C., Philippon A. FEMS Microbiol. Lett. 148:15-20(1997) [PubMed: 9066104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SLM01.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y10283 Genomic DNA. Translation: CAA71326.1.
3D structure databases
HSSP	HSSP built from PDB template 1FCO based on UniProtKB P00811.
ModBase	Search...
Protein family/group databases
MEROPS	S12.006.
Enzyme and pathway databases
BRENDA	3.5.2.6. 2621.
Family and domain databases
InterPro	IPR001586. Beta_lactam_C_AS. IPR001466. Beta_lactamase-related. [Graphical view]
Pfam	PF00144. Beta-lactamase. 1 hit. [Graphical view]
PROSITE	PS00336. BETA_LACTAMASE_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPC_MORMO

Accession

Primary (citable) accession number: P94958

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)