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P94958

- AMPC_MORMO

UniProt

P94958 - AMPC_MORMO

Protein

Beta-lactamase

Gene

ampC

Organism
Morganella morganii (Proteus morganii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    • Comment

    Functioni

    This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei83 – 831Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei169 – 1691Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Protein family/group databases

    MEROPSiS12.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Cephalosporinase
    Gene namesi
    Name:ampC
    OrganismiMorganella morganii (Proteus morganii)
    Taxonomic identifieri582 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeMorganella

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 379358Beta-lactamasePRO_0000016961Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP94958.
    SMRiP94958. Positions 25-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni333 – 3353Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-C beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P94958-1 [UniParc]FASTAAdd to Basket

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    MKKSLSATLI SALLAFSAPG FSAADNVAAV VDSTIKPLMA QQDIPGMAVA    50
    VSVKGKPYYF NYGFADVQAK QPVTENTLFE LGSVSKTFTG VLGAVSVAKK 100
    EMTLNDPAEK YQPELALPQW KGITLLDLAT YTAGGLPLQV PDAVKSRADL 150
    LHFYQQWQPS RKPGDMRLYA NSSIGLFGAL TANAAGMPYE QLLTARILAP 200
    LGLSHTFITV PESAQSQYAY GYKNKKPVRV SPGQLDAESY GVKSASKDML 250
    RWAEMNMEPS RAGNADLEMA MYLAQTRYYK TAAINQGLGW EMYDWPQQKD 300
    MIINGVTNEV ALQPHPVTDN QVQPYNRASW VHKTGATTGF GAYVAFIPEK 350
    QVAIVILANK NYPNTERVKA AQAILSALE 379
    Length:379
    Mass (Da):41,272
    Last modified:May 1, 1997 - v1
    Checksum:i2A6BA5C3B1862873
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10283 Genomic DNA. Translation: CAA71326.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10283 Genomic DNA. Translation: CAA71326.1 .

    3D structure databases

    ProteinModelPortali P94958.
    SMRi P94958. Positions 25-379.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL5764.

    Protein family/group databases

    MEROPSi S12.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the gene encoding the AmpC beta-lactamase of Morganella morganii."
      Barnaud G., Arlet G., Danglot C., Philippon A.
      FEMS Microbiol. Lett. 148:15-20(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SLM01.

    Entry informationi

    Entry nameiAMPC_MORMO
    AccessioniPrimary (citable) accession number: P94958
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3