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P94958 (AMPC_MORMO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Cephalosporinase
Gene names
Name:ampC
OrganismMorganella morganii (Proteus morganii)
Taxonomic identifier582 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeMorganella

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the class-C beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 379358Beta-lactamase
PRO_0000016961

Regions

Region333 – 3353Substrate binding By similarity

Sites

Active site831Acyl-ester intermediate By similarity
Active site1691Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P94958 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 2A6BA5C3B1862873

FASTA37941,272
        10         20         30         40         50         60 
MKKSLSATLI SALLAFSAPG FSAADNVAAV VDSTIKPLMA QQDIPGMAVA VSVKGKPYYF 

        70         80         90        100        110        120 
NYGFADVQAK QPVTENTLFE LGSVSKTFTG VLGAVSVAKK EMTLNDPAEK YQPELALPQW 

       130        140        150        160        170        180 
KGITLLDLAT YTAGGLPLQV PDAVKSRADL LHFYQQWQPS RKPGDMRLYA NSSIGLFGAL 

       190        200        210        220        230        240 
TANAAGMPYE QLLTARILAP LGLSHTFITV PESAQSQYAY GYKNKKPVRV SPGQLDAESY 

       250        260        270        280        290        300 
GVKSASKDML RWAEMNMEPS RAGNADLEMA MYLAQTRYYK TAAINQGLGW EMYDWPQQKD 

       310        320        330        340        350        360 
MIINGVTNEV ALQPHPVTDN QVQPYNRASW VHKTGATTGF GAYVAFIPEK QVAIVILANK 

       370 
NYPNTERVKA AQAILSALE 

« Hide

References

[1]"Cloning and sequencing of the gene encoding the AmpC beta-lactamase of Morganella morganii."
Barnaud G., Arlet G., Danglot C., Philippon A.
FEMS Microbiol. Lett. 148:15-20(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SLM01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y10283 Genomic DNA. Translation: CAA71326.1.

3D structure databases

ProteinModelPortalP94958.
SMRP94958. Positions 25-379.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL5764.

Protein family/group databases

MEROPSS12.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPC_MORMO
AccessionPrimary (citable) accession number: P94958
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families