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P94939 (KPYK_MYCIT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:pyk
Synonyms:pykF
OrganismMycobacterium intracellulare
Taxonomic identifier1767 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Pyruvate kinase
PRO_0000112080

Sites

Metal binding351Potassium By similarity
Metal binding371Potassium By similarity
Metal binding671Potassium By similarity
Metal binding2201Magnesium By similarity
Metal binding2441Magnesium By similarity
Binding site331Substrate By similarity
Binding site2431Substrate; via amide nitrogen By similarity
Binding site2441Substrate; via amide nitrogen By similarity
Binding site2761Substrate By similarity
Site2181Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P94939 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: A9D58F3E64E117D1

FASTA47250,462
        10         20         30         40         50         60 
MSRRGKIVCT LGPATNSDEL ILALVEAGMD VARLNFSHGD YADHKAAYER VRVASDATGR 

        70         80         90        100        110        120 
AVGVLADLQG PKIRLGRFAT GPTYWADGET VRITVADCEG SHDRVSTTYK KLAEDAAVGD 

       130        140        150        160        170        180 
RVLVDDGKVC LVVDGIEGDD VICTVVEGGP VSNNKGISLP GMNVSAPALS EKDIEDLTFA 

       190        200        210        220        230        240 
LDLGVDLVAL SFVRSPADVE LVHEVMDRVG RRVPVIAKLE KPEAVDNLET IVLAFDAIMV 

       250        260        270        280        290        300 
ARGDLGVELP LEEVPLVQKR AIQMARENAK PVIVATQMLD SMIENSRPTR AEASDVANAV 

       310        320        330        340        350        360 
LDGADAVMLS GETSVGKYPM AAVRTMSRII CAVEDNSTAA PPLTHVPRTK RGVISYAARD 

       370        380        390        400        410        420 
IGERLDAKAL VAFTQSGDTV KRLARLHTPL PLLAFTAWPE VRSQLAMTWG TETFIVPMMT 

       430        440        450        460        470 
STGGMIRQVD KSLLELGRYK RGDLVVIVAG APPGTVGSTN LIHVHRIGED DV 

« Hide

References

[1]Alavi M.R., Rouse D.A., Morris S.L.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Batty.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U65430 Genomic DNA. Translation: AAB39214.1.

3D structure databases

ProteinModelPortalP94939.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_MYCIT
AccessionPrimary (citable) accession number: P94939
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways