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P94939

- KPYK_MYCIT

UniProt

P94939 - KPYK_MYCIT

Protein

Pyruvate kinase

Gene

pyk

Organism
Mycobacterium intracellulare
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331SubstrateBy similarity
    Metal bindingi35 – 351PotassiumBy similarity
    Metal bindingi37 – 371PotassiumBy similarity
    Metal bindingi67 – 671PotassiumBy similarity
    Sitei218 – 2181Transition state stabilizerBy similarity
    Metal bindingi220 – 2201MagnesiumBy similarity
    Binding sitei243 – 2431Substrate; via amide nitrogenBy similarity
    Metal bindingi244 – 2441MagnesiumBy similarity
    Binding sitei244 – 2441Substrate; via amide nitrogenBy similarity
    Binding sitei276 – 2761SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pyk
    Synonyms:pykF
    OrganismiMycobacterium intracellulare
    Taxonomic identifieri1767 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Pyruvate kinasePRO_0000112080Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP94939.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P94939-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRGKIVCT LGPATNSDEL ILALVEAGMD VARLNFSHGD YADHKAAYER    50
    VRVASDATGR AVGVLADLQG PKIRLGRFAT GPTYWADGET VRITVADCEG 100
    SHDRVSTTYK KLAEDAAVGD RVLVDDGKVC LVVDGIEGDD VICTVVEGGP 150
    VSNNKGISLP GMNVSAPALS EKDIEDLTFA LDLGVDLVAL SFVRSPADVE 200
    LVHEVMDRVG RRVPVIAKLE KPEAVDNLET IVLAFDAIMV ARGDLGVELP 250
    LEEVPLVQKR AIQMARENAK PVIVATQMLD SMIENSRPTR AEASDVANAV 300
    LDGADAVMLS GETSVGKYPM AAVRTMSRII CAVEDNSTAA PPLTHVPRTK 350
    RGVISYAARD IGERLDAKAL VAFTQSGDTV KRLARLHTPL PLLAFTAWPE 400
    VRSQLAMTWG TETFIVPMMT STGGMIRQVD KSLLELGRYK RGDLVVIVAG 450
    APPGTVGSTN LIHVHRIGED DV 472
    Length:472
    Mass (Da):50,462
    Last modified:May 1, 1997 - v1
    Checksum:iA9D58F3E64E117D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U65430 Genomic DNA. Translation: AAB39214.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U65430 Genomic DNA. Translation: AAB39214.1 .

    3D structure databases

    ProteinModelPortali P94939.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Alavi M.R., Rouse D.A., Morris S.L.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Batty.

    Entry informationi

    Entry nameiKPYK_MYCIT
    AccessioniPrimary (citable) accession number: P94939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3