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P94846

- UVRB_HELPY

UniProt

P94846 - UVRB_HELPY

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Protein
UvrABC system protein B
Gene
uvrB, HP_1114
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. excinuclease ABC activity Source: UniProtKB-HAMAP
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1114-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein B
Short name:
Protein UvrB
Alternative name(s):
Excinuclease ABC subunit B
Gene namesi
Name:uvrB
Ordered Locus Names:HP_1114
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658UvrABC system protein BUniRule annotation
PRO_0000138396Add
BLAST

Proteomic databases

PRIDEiP94846.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity.

Protein-protein interaction databases

DIPiDIP-3238N.
IntActiP94846. 18 interactions.
MINTiMINT-171452.
STRINGi85962.HP1114.

Structurei

3D structure databases

ProteinModelPortaliP94846.
SMRiP94846. Positions 3-597.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 414390Helicase ATP-binding
Add
BLAST
Domaini433 – 607175Helicase C-terminal
Add
BLAST
Domaini623 – 65836UVR
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi91 – 11424Beta-hairpinUniRule annotation
Add
BLAST

Domaini

The beta-hairpin motif is involved in DNA binding By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0556.
KOiK03702.
OMAiESGNPLH.
OrthoDBiEOG6B360R.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 2 hits.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94846-1 [UniParc]FASTAAdd to Basket

« Hide

MPLFDLKSPY PPAGDQPQAI EALTKSLKNN NHYQTLVGVT GSGKTYTMAN    50
IIAQTNKPAL IMSHNKTLCA QLYSEFKAFF PHNRVEYFIS HFDYYQPESY 100
IPRRDLFIEK DSSINDDLER LRLSATTSLL GYDDVIVIAS VSANYGLGNP 150
EEYLKVMEKI KVGEKRAYKS FLLKLVEMGY SRNEVVFDRG SFRATGECVD 200
IFPAYNDAEF IRIEFFGDEI ERIAVFDALE KNEIKRLDSV MLYAASQFAV 250
GSERLNLAIK SIEDELALRL KFFKEQDKML EYNRLKQRTE HDLEMISATG 300
VCKGIENYAR HFTGKAPNET PFCLFDYLGI FEREFLVIVD ESHVSLPQFG 350
GMYAGDMSRK SVLVEYGFRL PSALDNRPLK FDEFIHKNCQ FLFVSATPNK 400
LELELSKKNV AEQIIRPTGL LDPKFEVRDS DKQVQDLFDE IKLVVARGER 450
VLITTLTKKM AEELCKYYAE WGLKARYMHS EIDAIERNHI IRSLRLKEFD 500
ILIGINLLRE GLDLPEVSLV AIMDADKEGF LRSETSLIQT MGRAARNANG 550
KVLLYAKKIT QSMQKAFEIT SYRRAKQEEF NKIHNITPKT VTRALEEELK 600
LRDDEIRIAK ALKKDKMPKS EREKIIKELD KKMRECTKNL DFEEAMRLRD 650
EIAQLRTL 658
Length:658
Mass (Da):75,916
Last modified:November 1, 1997 - v2
Checksum:i06BC0EE689AB3ADE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591A → T in strain: 84-183.
Natural varianti231 – 2311K → R in strain: 84-183.
Natural varianti259 – 2591I → V in strain: 84-183.
Natural varianti376 – 3761N → T in strain: 84-183.
Natural varianti407 – 4071K → Q in strain: 84-183.
Natural varianti443 – 4431L → S in strain: 84-183.
Natural varianti475 – 4751A → V in strain: 84-183.
Natural varianti501 – 5011I → V in strain: 84-183.
Natural varianti607 – 6071R → K in strain: 84-183.
Natural varianti636 – 6372CT → HA in strain: 84-183.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80807 Genomic DNA. Translation: AAC46270.1.
AE000511 Genomic DNA. Translation: AAD08158.1.
PIRiB64659.
RefSeqiNP_207905.1. NC_000915.1.
YP_006935029.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08158; AAD08158; HP_1114.
GeneIDi13870307.
899650.
KEGGiheo:C694_05745.
hpy:HP1114.
PATRICi20593569. VBIHelPyl33062_1164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80807 Genomic DNA. Translation: AAC46270.1 .
AE000511 Genomic DNA. Translation: AAD08158.1 .
PIRi B64659.
RefSeqi NP_207905.1. NC_000915.1.
YP_006935029.1. NC_018939.1.

3D structure databases

ProteinModelPortali P94846.
SMRi P94846. Positions 3-597.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3238N.
IntActi P94846. 18 interactions.
MINTi MINT-171452.
STRINGi 85962.HP1114.

Proteomic databases

PRIDEi P94846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08158 ; AAD08158 ; HP_1114 .
GeneIDi 13870307.
899650.
KEGGi heo:C694_05745.
hpy:HP1114.
PATRICi 20593569. VBIHelPyl33062_1164.

Phylogenomic databases

eggNOGi COG0556.
KOi K03702.
OMAi ESGNPLH.
OrthoDBi EOG6B360R.

Enzyme and pathway databases

BioCyci HPY:HP1114-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPi MF_00204. UvrB.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view ]
PANTHERi PTHR24029. PTHR24029. 1 hit.
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00631. uvrb. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 2 hits.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the Helicobacter pylori uvr B gene."
    Thompson S.A., Latch R.L., Blaser J.M.
    Gene 209:113-122(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 53726 / 84-183.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiUVRB_HELPY
AccessioniPrimary (citable) accession number: P94846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi