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P94845 (GLNA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Ordered Locus Names:HP_0512
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Subunit structure

Oligomer of 12 subunits arranged in the form of two hexagons By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Glutamine synthetase
PRO_0000153239

Experimental info

Sequence conflict3961I → M in AAB39719. Ref.2
Sequence conflict4431S → G in AAB39719. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P94845 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 87EDFEB540723D3E

FASTA48154,514
        10         20         30         40         50         60 
MIVRTQNSES KIKEFFEFCK ENEVEFVDFR FSDIKGTWNH IAYSFGALTH GMLKEGIPFD 

        70         80         90        100        110        120 
ASCFKGWQGI EHSDMILTPD LVRYFIDPFS ADVSVVVFCD VYDVYKNQPY EKCPRSIAKK 

       130        140        150        160        170        180 
ALQHLKDSGL GDVAYFGAEN EFFIFDSIKI KDASNSQYYE VDSEEGEWNR DRSFENGVNF 

       190        200        210        220        230        240 
GHRPGKQGGY MPVPPTDTMM DIRTEIVKVL NQVGLETFVV HHEVAQAQGE VGVKFGDLVE 

       250        260        270        280        290        300 
AADNVQKLKY VVKMVAHLNG KTATFMPKPL YGDNGSGMHT HVSVWKNNEN LFSGETYKGL 

       310        320        330        340        350        360 
SEFALHFLGG VLRHARGLAA FTNASTNSYK RLIPGYEAPS ILTYSANNRS ASVRIPYGIS 

       370        380        390        400        410        420 
KNSARFEFRF PDSSSNPYLA FAAILMAGMD GVKNKIDPGE AMDINLFKLT LDEIREKGIK 

       430        440        450        460        470        480 
QMPHTLRRSL EEMLADKQYL KESQVFSEEF IQAYQSLKFN AEVFPWESKP HPFEFITTYS 


C 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
[2]"Sequence of the dihydrodipicolinate reductase gene (dapB) from Helicobacter pylori and complementation in Escherichia coli."
Clairoux N., Boissinot M.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 367-481.
Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07575.1.
U75328 Genomic DNA. Translation: AAB39719.1.
PIRH64583.
RefSeqNP_207309.1. NC_000915.1.
YP_006934432.1. NC_018939.1.

3D structure databases

ProteinModelPortalP94845.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3543N.
IntActP94845. 1 interaction.
MINTMINT-172713.
STRING85962.HP0512.

Proteomic databases

PRIDEP94845.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07575; AAD07575; HP_0512.
GeneID13869700.
900049.
KEGGheo:C694_02630.
hpy:HP0512.
PATRIC20592299. VBIHelPyl33062_0538.

Phylogenomic databases

eggNOGCOG0174.
KOK01915.
OMARAHHEVG.
OrthoDBEOG6B360N.
ProtClustDBCLSK872373.

Enzyme and pathway databases

BioCycHPY:HP0512-MONOMER.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_HELPY
AccessionPrimary (citable) accession number: P94845
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names