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P94845

- GLNA_HELPY

UniProt

P94845 - GLNA_HELPY

Protein

Glutamine synthetase

Gene

glnA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine biosynthetic process Source: InterPro
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0512-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:HP_0512
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481Glutamine synthetasePRO_0000153239Add
    BLAST

    Proteomic databases

    PRIDEiP94845.

    Interactioni

    Subunit structurei

    Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

    Protein-protein interaction databases

    DIPiDIP-3543N.
    IntActiP94845. 14 interactions.
    MINTiMINT-172713.
    STRINGi85962.HP0512.

    Structurei

    3D structure databases

    ProteinModelPortaliP94845.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    KOiK01915.
    OMAiSCRIPYV.
    OrthoDBiEOG6B360N.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P94845-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVRTQNSES KIKEFFEFCK ENEVEFVDFR FSDIKGTWNH IAYSFGALTH    50
    GMLKEGIPFD ASCFKGWQGI EHSDMILTPD LVRYFIDPFS ADVSVVVFCD 100
    VYDVYKNQPY EKCPRSIAKK ALQHLKDSGL GDVAYFGAEN EFFIFDSIKI 150
    KDASNSQYYE VDSEEGEWNR DRSFENGVNF GHRPGKQGGY MPVPPTDTMM 200
    DIRTEIVKVL NQVGLETFVV HHEVAQAQGE VGVKFGDLVE AADNVQKLKY 250
    VVKMVAHLNG KTATFMPKPL YGDNGSGMHT HVSVWKNNEN LFSGETYKGL 300
    SEFALHFLGG VLRHARGLAA FTNASTNSYK RLIPGYEAPS ILTYSANNRS 350
    ASVRIPYGIS KNSARFEFRF PDSSSNPYLA FAAILMAGMD GVKNKIDPGE 400
    AMDINLFKLT LDEIREKGIK QMPHTLRRSL EEMLADKQYL KESQVFSEEF 450
    IQAYQSLKFN AEVFPWESKP HPFEFITTYS C 481
    Length:481
    Mass (Da):54,514
    Last modified:November 1, 1997 - v2
    Checksum:i87EDFEB540723D3E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti396 – 3961I → M in AAB39719. 1 PublicationCurated
    Sequence conflicti443 – 4431S → G in AAB39719. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07575.1.
    U75328 Genomic DNA. Translation: AAB39719.1.
    PIRiH64583.
    RefSeqiNP_207309.1. NC_000915.1.
    YP_006934432.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07575; AAD07575; HP_0512.
    GeneIDi13869700.
    900049.
    KEGGiheo:C694_02630.
    hpy:HP0512.
    PATRICi20592299. VBIHelPyl33062_0538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07575.1 .
    U75328 Genomic DNA. Translation: AAB39719.1 .
    PIRi H64583.
    RefSeqi NP_207309.1. NC_000915.1.
    YP_006934432.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P94845.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3543N.
    IntActi P94845. 14 interactions.
    MINTi MINT-172713.
    STRINGi 85962.HP0512.

    Proteomic databases

    PRIDEi P94845.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07575 ; AAD07575 ; HP_0512 .
    GeneIDi 13869700.
    900049.
    KEGGi heo:C694_02630.
    hpy:HP0512.
    PATRICi 20592299. VBIHelPyl33062_0538.

    Phylogenomic databases

    eggNOGi COG0174.
    KOi K01915.
    OMAi SCRIPYV.
    OrthoDBi EOG6B360N.

    Enzyme and pathway databases

    BioCyci HPY:HP0512-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. "Sequence of the dihydrodipicolinate reductase gene (dapB) from Helicobacter pylori and complementation in Escherichia coli."
      Clairoux N., Boissinot M.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 367-481.
      Strain: DSM 4867 / CCUG 17874 / NCTC 11638.

    Entry informationi

    Entry nameiGLNA_HELPY
    AccessioniPrimary (citable) accession number: P94845
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3