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Protein

Glutamine synthetase

Gene

glnA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP0512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:HP_0512
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Glutamine synthetasePRO_0000153239Add
BLAST

Proteomic databases

PRIDEiP94845.

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

DIPiDIP-3543N.
IntActiP94845. 14 interactions.
MINTiMINT-172713.
STRINGi85962.HP0512.

Structurei

3D structure databases

ProteinModelPortaliP94845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
KOiK01915.
OMAiKVLNQVG.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVRTQNSES KIKEFFEFCK ENEVEFVDFR FSDIKGTWNH IAYSFGALTH
60 70 80 90 100
GMLKEGIPFD ASCFKGWQGI EHSDMILTPD LVRYFIDPFS ADVSVVVFCD
110 120 130 140 150
VYDVYKNQPY EKCPRSIAKK ALQHLKDSGL GDVAYFGAEN EFFIFDSIKI
160 170 180 190 200
KDASNSQYYE VDSEEGEWNR DRSFENGVNF GHRPGKQGGY MPVPPTDTMM
210 220 230 240 250
DIRTEIVKVL NQVGLETFVV HHEVAQAQGE VGVKFGDLVE AADNVQKLKY
260 270 280 290 300
VVKMVAHLNG KTATFMPKPL YGDNGSGMHT HVSVWKNNEN LFSGETYKGL
310 320 330 340 350
SEFALHFLGG VLRHARGLAA FTNASTNSYK RLIPGYEAPS ILTYSANNRS
360 370 380 390 400
ASVRIPYGIS KNSARFEFRF PDSSSNPYLA FAAILMAGMD GVKNKIDPGE
410 420 430 440 450
AMDINLFKLT LDEIREKGIK QMPHTLRRSL EEMLADKQYL KESQVFSEEF
460 470 480
IQAYQSLKFN AEVFPWESKP HPFEFITTYS C
Length:481
Mass (Da):54,514
Last modified:October 31, 1997 - v2
Checksum:i87EDFEB540723D3E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3961I → M in AAB39719 (Ref. 2) Curated
Sequence conflicti443 – 4431S → G in AAB39719 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07575.1.
U75328 Genomic DNA. Translation: AAB39719.1.
PIRiH64583.
RefSeqiNP_207309.1. NC_000915.1.
YP_006934432.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07575; AAD07575; HP_0512.
GeneIDi13869700.
900049.
KEGGiheo:C694_02630.
hpy:HP0512.
PATRICi20592299. VBIHelPyl33062_0538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07575.1.
U75328 Genomic DNA. Translation: AAB39719.1.
PIRiH64583.
RefSeqiNP_207309.1. NC_000915.1.
YP_006934432.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP94845.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3543N.
IntActiP94845. 14 interactions.
MINTiMINT-172713.
STRINGi85962.HP0512.

Proteomic databases

PRIDEiP94845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07575; AAD07575; HP_0512.
GeneIDi13869700.
900049.
KEGGiheo:C694_02630.
hpy:HP0512.
PATRICi20592299. VBIHelPyl33062_0538.

Phylogenomic databases

eggNOGiCOG0174.
KOiK01915.
OMAiKVLNQVG.
OrthoDBiEOG6B360N.

Enzyme and pathway databases

BioCyciHPY:HP0512-MONOMER.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. "Sequence of the dihydrodipicolinate reductase gene (dapB) from Helicobacter pylori and complementation in Escherichia coli."
    Clairoux N., Boissinot M.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 367-481.
    Strain: DSM 4867 / CCUG 17874 / NCTC 11638.

Entry informationi

Entry nameiGLNA_HELPY
AccessioniPrimary (citable) accession number: P94845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1997
Last modified: January 6, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.