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Protein

60 kDa chaperonin

Gene

groL

Organism
Holospora obtusa
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
OrganismiHolospora obtusa
Taxonomic identifieri49893 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesHolosporaceaeHolospora

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633911 – 55460 kDa chaperoninAdd BLAST554

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP94820.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKQIAFGS KVGESLLNGV IKLANCVQVT LGPNGRNVLI EQSFGDPRVT
60 70 80 90 100
KDGVTVAKHV ELEDRYENLA AQLVKSVASK TADMVGDGTT TATVLARSIY
110 120 130 140 150
SEAFKGTSAG MNSMELRAGI DHAVEIVVEK LKELSIPVKG DYQKISQVAT
160 170 180 190 200
VSANGDTEIG DMIAQAMEKV GSDGVITVEE AKSFKTELDV VPGMQFDRGY
210 220 230 240 250
ISPYFITRQD KGIAELERSY ILLYDGKISS AQSLLPVLEK CAKESASLLI
260 270 280 290 300
IAEDVEGEAL RMLVVNKLRG VLKVAAVKSP GFGDRRKAML GDIAVLTNGY
310 320 330 340 350
VVSSEVGMRL EDVRIEDLGR ADTIVIEKDN TTVIVNGPAR SSVKERCDKI
360 370 380 390 400
RSEIQEATSD YDKEKLQERL AKLSGGVAVI RVGGATEVEL KERKDRVEDA
410 420 430 440 450
MHATKAAVEE GIIPGGGTAF LRCVKPLEEV IKSAKVQERG RDFICGIDAV
460 470 480 490 500
RKALSSPCYQ IASNAGKEGG VVVAEVLKAS DVNVGYDARH DQYVDMIKSG
510 520 530 540 550
IIDPTKVART ALQNAGSVAG LLNTTEVIIA QVPEKEKPNM GGGMGGGMGG

GMDF
Length:554
Mass (Da):59,159
Last modified:May 1, 1997 - v1
Checksum:i5CCB9866F5AA2F08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89970 Genomic DNA. Translation: BAA14046.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89970 Genomic DNA. Translation: BAA14046.1.

3D structure databases

ProteinModelPortaliP94820.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_HOLOB
AccessioniPrimary (citable) accession number: P94820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.