Reviewed, UniProtKB/Swiss-Prot P94693 (DSVA_DESGI)

Names and origin

Protein names

Recommended name:
    Sulfite reductase, dissimilatory-type subunit alpha
    EC=1.8.99.3
Alternative name(s):
    Desulfoviridin subunit alpha
    Hydrogensulfite reductase alpha subunit

Gene names

Name:

dsrA

Organism

Desulfovibrio gigas

Taxonomic identifier

879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	198 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reduction of sulfite to sulfide. This is the terminal oxidation reaction in sulfate respiration, a process catalyzed by the sulfate-reducing bacteria.
Catalytic activity	(O(3)S.S.SO(3))(2-) + acceptor + 2 H(2)O + OH(-) = 3 HSO(3)(-) + reduced acceptor.
Cofactor	Binds 1 4Fe-4S cluster per subunit By similarity. Binds 2 sirohemes per subunit By similarity.
Subunit structure	Heterohexamer of two alpha, two beta and two gamma subunits.
Sequence similarities	Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Ligand	4Fe-4S Heme Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro hydrogensulfite reductase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 198	›198	Sulfite reductase, dissimilatory-type subunit alpha		PRO_0000080029
Regions
	Domain	55 – 83	29	4Fe-4S ferredoxin-type
Sites
	Metal binding	45	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	64	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	67	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	70	1	Iron-sulfur (4Fe-4S) Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P94693-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 92B9643231A98AE4	FASTA	198	22,384
	10 20 30 40 50 60 WKDDIKIDQE AVKAYVGGEF KPNAGAHAGR DWGKFDIEAE VVGLCPTGCM TYESGTLSID 70 80 90 100 110 120 NKNCTRCMHC INTMPRALKI GDERGASILV GAKAPVLDGA QMGSLLIPFI AAEEPFDEVK 130 140 150 160 170 180 EVIENIWEWW MEEGKNRERL GETMKRVGFQ KLLEVTGTKA VPQHVSEPRH NPYIFFKEEE 190 VPGGWSRDIS DYRKRHMR

References

[1]	Hipp W.M., Trueper H.G. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 19364 / DSM 1382 / NCIB 9332 / VKM B-1759.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U80961 Genomic DNA. Translation: AAB41001.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR006067. Nir_Sir_4Fe4S. [Graphical view]
Pfam	PF01077. NIR_SIR. 1 hit. [Graphical view]
PROSITE	PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSVA_DESGI

Accession

Primary (citable) accession number: P94693

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 1, 1997
Last modified:	November 25, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)