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Protein

Basic cytochrome c3

Gene
N/A
Organism
Desulfovibrio africanus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Exchanges electrons with [NiFe] and [Fe] hydrogenases and with the acidic cytochrome c3. Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin.1 Publication

Miscellaneous

The second heme binding site has an unusual CXXXXCH motif.Combined sources1 Publication

Cofactori

heme1 PublicationNote: Binds 4 heme groups covalently per monomer.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34CalciumCombined sources1 Publication1
Metal bindingi36Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi44CalciumCombined sources1 Publication1
Metal bindingi45Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi51Iron (heme 1 axial ligand); via tele nitrogenCombined sources1 Publication1
Metal bindingi54Iron (heme 3 axial ligand); via tele nitrogenCombined sources1 Publication1
Binding sitei64Heme 1 (covalent)Combined sources1 Publication1
Binding sitei67Heme 1 (covalent)Combined sources1 Publication1
Metal bindingi68Iron (heme 1 axial ligand); via tele nitrogenCombined sources1 Publication1
Metal bindingi69Iron (heme 2 axial ligand); via tele nitrogenCombined sources1 Publication1
Binding sitei80Heme 2 (covalent); atypicalCombined sources1 Publication1
Binding sitei85Heme 2 (covalent); atypicalCombined sources1 Publication1
Metal bindingi86Iron (heme 2 axial ligand); via tele nitrogenCombined sources1 Publication1
Metal bindingi107Iron (heme 4 axial ligand); via tele nitrogenCombined sources1 Publication1
Binding sitei114Heme 3 (covalent)Combined sources1 Publication1
Binding sitei117Heme 3 (covalent)Combined sources1 Publication1
Metal bindingi118Iron (heme 3 axial ligand); via tele nitrogenCombined sources1 Publication1
Binding sitei133Heme 4 (covalent)Combined sources1 Publication1
Binding sitei136Heme 4 (covalent)Combined sources1 Publication1
Metal bindingi137Iron (heme 4 axial ligand); via tele nitrogenCombined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Sulfate respiration, Transport
LigandCalcium, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic cytochrome c3
OrganismiDesulfovibrio africanus
Taxonomic identifieri873 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000650324 – 140Basic cytochrome c3Add BLAST117

Interactioni

Protein-protein interaction databases

STRINGi690850.Desaf_1770.

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi41 – 43Combined sources3
Beta strandi47 – 49Combined sources3
Helixi52 – 57Combined sources6
Helixi61 – 65Combined sources5
Beta strandi73 – 75Combined sources3
Beta strandi80 – 82Combined sources3
Helixi102 – 107Combined sources6
Beta strandi108 – 110Combined sources3
Helixi114 – 121Combined sources8
Helixi122 – 124Combined sources3
Helixi133 – 137Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BQ4X-ray1.68A/B25-140[»]
ProteinModelPortaliP94691.
SMRiP94691.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP94691.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105XNI. Bacteria.
ENOG41121XT. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
PfamiView protein in Pfam
PF02085. Cytochrom_CIII. 1 hit.
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiView protein in PROSITE
PS51008. MULTIHEME_CYTC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94691-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLFSMLVA AALVGTMAMA AQAVPQVPAD VVIDHLSNPN AKLEYKVKFS
60 70 80 90 100
HKAHASLGTD AAACQKCHHK WDGKSEIGGC ATEGCHADTT SFKATEKDPK
110 120 130 140
FLMTAFHSKS PMSCQGCHKE MKTAKKTTGP TACAQCHNQK
Length:140
Mass (Da):14,975
Last modified:May 1, 1997 - v1
Checksum:iEA2A805423F416D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66K → S AA sequence (PubMed:8573595).Curated1

Mass spectrometryi

Molecular mass is 15102 Da from positions 23 - 140. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09717 Genomic DNA. Translation: CAA70883.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09717 Genomic DNA. Translation: CAA70883.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BQ4X-ray1.68A/B25-140[»]
ProteinModelPortaliP94691.
SMRiP94691.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi690850.Desaf_1770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105XNI. Bacteria.
ENOG41121XT. LUCA.

Miscellaneous databases

EvolutionaryTraceiP94691.

Family and domain databases

InterProiView protein in InterPro
IPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
PfamiView protein in Pfam
PF02085. Cytochrom_CIII. 1 hit.
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiView protein in PROSITE
PS51008. MULTIHEME_CYTC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYC3B_DESAF
AccessioniPrimary (citable) accession number: P94691
Secondary accession number(s): Q9R4E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.