Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Basic cytochrome c3

Gene
N/A
Organism
Desulfovibrio africanus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Exchanges electrons with [NiFe] and [Fe] hydrogenases and with the acidic cytochrome c3. Participates in sulfate respiration coupled with phosphorylation by transferring electrons from the enzyme dehydrogenase to ferredoxin.1 Publication

Cofactori

heme1 PublicationNote: Binds 4 heme groups covalently per monomer.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34CalciumCombined sources1 Publication1
Metal bindingi36Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi44CalciumCombined sources1 Publication1
Metal bindingi45Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi51Iron (heme 1 axial ligand); via tele nitrogenCombined sources1 Publication1
Metal bindingi54Iron (heme 3 axial ligand); via tele nitrogenCombined sources1 Publication1
Binding sitei64Heme 1 (covalent)Combined sources1 Publication1
Binding sitei67Heme 1 (covalent)Combined sources1 Publication1
Metal bindingi68Iron (heme 1 axial ligand); via tele nitrogenCombined sources1 Publication1
Metal bindingi69Iron (heme 2 axial ligand); via tele nitrogenCombined sources1 Publication1
Binding sitei80Heme 2 (covalent); atypicalCombined sources1 Publication1
Binding sitei85Heme 2 (covalent); atypicalCombined sources1 Publication1
Metal bindingi86Iron (heme 2 axial ligand); via tele nitrogenCombined sources1 Publication1
Metal bindingi107Iron (heme 4 axial ligand); via tele nitrogenCombined sources1 Publication1
Binding sitei114Heme 3 (covalent)Combined sources1 Publication1
Binding sitei117Heme 3 (covalent)Combined sources1 Publication1
Metal bindingi118Iron (heme 3 axial ligand); via tele nitrogenCombined sources1 Publication1
Binding sitei133Heme 4 (covalent)Combined sources1 Publication1
Binding sitei136Heme 4 (covalent)Combined sources1 Publication1
Metal bindingi137Iron (heme 4 axial ligand); via tele nitrogenCombined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Sulfate respiration, Transport

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic cytochrome c3
OrganismiDesulfovibrio africanus
Taxonomic identifieri873 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000650324 – 140Basic cytochrome c3Add BLAST117

Interactioni

Protein-protein interaction databases

STRINGi690850.Desaf_1770.

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi41 – 43Combined sources3
Beta strandi47 – 49Combined sources3
Helixi52 – 57Combined sources6
Helixi61 – 65Combined sources5
Beta strandi73 – 75Combined sources3
Beta strandi80 – 82Combined sources3
Helixi102 – 107Combined sources6
Beta strandi108 – 110Combined sources3
Helixi114 – 121Combined sources8
Helixi122 – 124Combined sources3
Helixi133 – 137Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BQ4X-ray1.68A/B25-140[»]
ProteinModelPortaliP94691.
SMRiP94691.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP94691.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105XNI. Bacteria.
ENOG41121XT. LUCA.

Family and domain databases

InterProiIPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamiPF02085. Cytochrom_CIII. 1 hit.
[Graphical view]
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94691-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLFSMLVA AALVGTMAMA AQAVPQVPAD VVIDHLSNPN AKLEYKVKFS
60 70 80 90 100
HKAHASLGTD AAACQKCHHK WDGKSEIGGC ATEGCHADTT SFKATEKDPK
110 120 130 140
FLMTAFHSKS PMSCQGCHKE MKTAKKTTGP TACAQCHNQK
Length:140
Mass (Da):14,975
Last modified:May 1, 1997 - v1
Checksum:iEA2A805423F416D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66K → S AA sequence (PubMed:8573595).Curated1

Mass spectrometryi

Molecular mass is 15102 Da from positions 23 - 140. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09717 Genomic DNA. Translation: CAA70883.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09717 Genomic DNA. Translation: CAA70883.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BQ4X-ray1.68A/B25-140[»]
ProteinModelPortaliP94691.
SMRiP94691.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi690850.Desaf_1770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105XNI. Bacteria.
ENOG41121XT. LUCA.

Miscellaneous databases

EvolutionaryTraceiP94691.

Family and domain databases

InterProiIPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamiPF02085. Cytochrom_CIII. 1 hit.
[Graphical view]
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC3B_DESAF
AccessioniPrimary (citable) accession number: P94691
Secondary accession number(s): Q9R4E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The second heme binding site has an unusual CXXXXCH motif.Combined sources1 Publication

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.