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Protein

Acidic cytochrome c3

Gene
N/A
Organism
Desulfovibrio africanus
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exchanges electrons specifically with the basic cytochrome c3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Iron (heme 1 axial ligand)1
Metal bindingi51Iron (heme 3 axial ligand)1
Binding sitei60Heme 1 (covalent)1
Binding sitei63Heme 1 (covalent)1
Metal bindingi64Iron (heme 1 axial ligand)1
Metal bindingi65Iron (heme 2 axial ligand)1
Binding sitei83Heme 2 (covalent)1
Binding sitei86Heme 2 (covalent)1
Metal bindingi87Iron (heme 2 axial ligand)1
Metal bindingi103Iron (heme 4 axial ligand)1
Binding sitei106Heme 3 (covalent)1
Binding sitei109Heme 3 (covalent)1
Metal bindingi110Iron (heme 3 axial ligand)1
Binding sitei120Heme 4 (covalent)1
Binding sitei123Heme 4 (covalent)1
Metal bindingi124Iron (heme 4 axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Sulfate respiration, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic cytochrome c3
OrganismiDesulfovibrio africanus
Taxonomic identifieri873 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000000650225 – 127Acidic cytochrome c3Add BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Pyrrolidone carboxylic acid1

Post-translational modificationi

Binds 4 heme groups per subunit.
The N-terminus is blocked.

Keywords - PTMi

Pyrrolidone carboxylic acid

Interactioni

Protein-protein interaction databases

STRINGi690850.Desaf_0450.

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 36Combined sources3
Helixi48 – 55Combined sources8
Helixi60 – 62Combined sources3
Helixi83 – 85Combined sources3
Helixi98 – 113Combined sources16
Helixi120 – 123Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CAOX-ray1.60A26-127[»]
3CARX-ray1.90A26-127[»]
ProteinModelPortaliP94690.
SMRiP94690.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP94690.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG41062QK. Bacteria.
ENOG4112BW6. LUCA.

Family and domain databases

InterProiIPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamiPF02085. Cytochrom_CIII. 1 hit.
[Graphical view]
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKHTLIALT LLAAATLFSL PAFSQEDMTH VPTDAFGKLE RPAAVFNHDE
60 70 80 90 100
HNEKAGIESC NACHHVWVNG VLAEDEDSVG TPCSDCHALE QDGDTPGLQD
110 120
AYHQQCWGCH EKQAKGPVMC GECHVKN
Length:127
Mass (Da):13,856
Last modified:May 1, 1997 - v1
Checksum:iDE6E3B16FA4BF8B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67W → P AA sequence (PubMed:8573595).Curated1

Mass spectrometryi

Molecular mass is 13742±1.2 Da from positions 25 - 117. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09718 Genomic DNA. Translation: CAA70884.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09718 Genomic DNA. Translation: CAA70884.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CAOX-ray1.60A26-127[»]
3CARX-ray1.90A26-127[»]
ProteinModelPortaliP94690.
SMRiP94690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi690850.Desaf_0450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG41062QK. Bacteria.
ENOG4112BW6. LUCA.

Miscellaneous databases

EvolutionaryTraceiP94690.

Family and domain databases

InterProiIPR002322. Cyt_c_III.
IPR020942. Cyt_c_III_dom.
IPR011031. Multihaem_cyt.
[Graphical view]
PfamiPF02085. Cytochrom_CIII. 1 hit.
[Graphical view]
PRINTSiPR00609. CYTOCHROMEC3.
SUPFAMiSSF48695. SSF48695. 1 hit.
PROSITEiPS51008. MULTIHEME_CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC3A_DESAF
AccessioniPrimary (citable) accession number: P94690
Secondary accession number(s): Q9R4E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.