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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Chlamydia trachomatis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf_4), Glucose-6-phosphate 1-dehydrogenase (zwf_2), Glucose-6-phosphate 1-dehydrogenase (zwf_3), Glucose-6-phosphate 1-dehydrogenase (zwf_1), Glucose-6-phosphate 1-dehydrogenase (zwf_2), Glucose-6-phosphate 1-dehydrogenase (zwf_2), Glucose-6-phosphate 1-dehydrogenase (zwf_3), Glucose-6-phosphate 1-dehydrogenase (zwf_2), Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd_2), 6-phosphogluconate dehydrogenase, decarboxylating (gnd_1), 6-phosphogluconate dehydrogenase, decarboxylating (gnd_2), 6-phosphogluconate dehydrogenase, decarboxylating (gnd_2), 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd_1), 6-phosphogluconate dehydrogenase, decarboxylating (gnd_2)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621NADPUniRule annotation
Binding sitei173 – 1731NADPUniRule annotation
Binding sitei203 – 2031SubstrateUniRule annotation
Binding sitei207 – 2071SubstrateUniRule annotation
Binding sitei241 – 2411SubstrateUniRule annotation
Binding sitei260 – 2601SubstrateUniRule annotation
Active sitei265 – 2651Proton acceptorUniRule annotation
Binding sitei361 – 3611SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotationImported
OrganismiChlamydia trachomatisImported
Taxonomic identifieri813 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Interactioni

Protein-protein interaction databases

STRINGi272561.CT185.

Structurei

3D structure databases

ProteinModelPortaliP94684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 212188G6PD_NInterPro annotationAdd
BLAST
Domaini215 – 510296G6PD_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGCTLEEIK DFGPTLPACP PCIVVIFGAT GDLTSRKLFP ALYNLTKEGR
60 70 80 90 100
LSENFVCVGF ARRPKSHEQF LEEMKLAVQH FSHSSEIDIR VWESLENRIF
110 120 130 140 150
YHQANFSDAE GYSALKAYLE QLDQQYGTQG NRLFYLSTPP DYFQEIIRNL
160 170 180 190 200
NRHQLFYHEQ GAQQPWSRLI IEKPFGVNLE TARELQQCID ANIDEESVYR
210 220 230 240 250
IDHYLGKETV QNILTIRFAN TLFESCWNSQ YIDHVQISVS ESIGIGSRGN
260 270 280 290 300
FFEKSGMLRD MVQNHLTQLL CLLTMEPPSE FSSEEIKKEK IKILKKILPI
310 320 330 340 350
REEDAVRGQY GEGIVQDVSV LGYREEENVD PNSSVETYVA LKLFIDNPRW
360 370 380 390 400
KGVPFYLQAG KRLTKRTTDI AVIFKKSSYN LFNAENCPLC PLENDLLIIR
410 420 430 440 450
IQPDEGVALQ FNCKVPGTNK LVRPVKMDFR YDSYFNTVTP EAYERLLCDC
460 470 480 490 500
ILGDRTLFTS NEEVLASWEL FSPLLEKWSQ VHPIFPNYMA GSLRPQEADE
510
LLSRDGKAWR PY
Length:512
Mass (Da):59,045
Last modified:March 1, 2003 - v2
Checksum:iF3E5BCC56ACA226F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83195 Genomic DNA. Translation: AAB41225.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83195 Genomic DNA. Translation: AAB41225.1.

3D structure databases

ProteinModelPortaliP94684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Glucose metabolism in Chlamydia trachomatis: the 'energy parasite' hypothesis revisited."
    Iliffe-Lee E.R., McClarty G.
    Mol. Microbiol. 33:177-187(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L2Imported.

Entry informationi

Entry nameiP94684_CHLTH
AccessioniPrimary (citable) accession number: P94684
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.