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Protein

4-formylbenzenesulfonate dehydrogenase TsaC1/TsaC2

Gene

tsaC1

more
Organism
Comamonas testosteroni (Pseudomonas testosteroni)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the toluene-4-sulfonate degradation pathway. Does not discriminate between the sulfonate and the carboxyl substituents and can also be involved in the p-toluenecarboxylate degradation pathway.2 Publications

Catalytic activityi

4-formylbenzenesulfonate + NAD+ + H2O = 4-sulfobenzoate + NADH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62NADBy similarity1
Binding sitei142SubstrateBy similarity1
Active sitei155Proton acceptorPROSITE-ProRule annotation1
Binding sitei159NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 36NADBy similarityAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:TSACCOTE-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
4-formylbenzenesulfonate dehydrogenase TsaC1/TsaC2 (EC:1.2.1.62)
Alternative name(s):
Toluenesulfonate zinc-independent alcohol dehydrogenase TsaC
Gene namesi
Name:tsaC1
Synonyms:tsaC
AND
Name:tsaC2
Encoded oniPlasmid pTSA3 Publications
OrganismiComamonas testosteroni (Pseudomonas testosteroni)
Taxonomic identifieri285 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004191161 – 2524-formylbenzenesulfonate dehydrogenase TsaC1/TsaC2Add BLAST252

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP94681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 78Ala-richAdd BLAST60

Sequence similaritiesi

Phylogenomic databases

KOiK19630.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLNKQVAIV TGGASGFGAA IARRLSQAGA AVLVADLNAE GAQRMATELN
60 70 80 90 100
AAGGRALGMA CDVSKEADYR AVVDAAIAQL GGLHIVVNNA GTTHRNKPAL
110 120 130 140 150
AVTEDEFDRV YRVNLKSVYW SAQCALPHFA QQGHGVMVNV ASTTGVRPGP
160 170 180 190 200
GLTWYSGSKA AMINLTKGLA LEFARSGVRI NAVNPMIGET PMMADFMGME
210 220 230 240 250
DTPANRERFL SRIPLGRFTR PDDVASAVAF LASDDASFLT GVCLDVDGGR

NI
Length:252
Mass (Da):26,438
Last modified:May 1, 1997 - v1
Checksum:i763A74DDABD2755C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311437 Genomic DNA. Translation: AAC44807.1.
AF311437 Genomic DNA. Translation: AAK37998.1.

Genome annotation databases

KEGGiag:AAC44807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311437 Genomic DNA. Translation: AAC44807.1.
AF311437 Genomic DNA. Translation: AAK37998.1.

3D structure databases

ProteinModelPortaliP94681.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAC44807.

Phylogenomic databases

KOiK19630.

Enzyme and pathway databases

BioCyciMetaCyc:TSACCOTE-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSAC_COMTE
AccessioniPrimary (citable) accession number: P94681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

TsaC2 is probably the product of a pseudogene and is not expressed, due to the absence of promoter-like sequences upstream of the operon tsaMBCD2.1 Publication

Keywords - Technical termi

Direct protein sequencing, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.