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Protein

Large cysteine-rich periplasmic protein OmcB

Gene

omcB

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan. It is present but the disulfide bonds are reduced in reticulate bodies (RBs) (By similarity).By similarity

Caution

Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl; however based on experiments in C.psittaci it is likely to be periplasmic.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell shape

Enzyme and pathway databases

BioCyciCCAV227941:G1G03-196-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Large cysteine-rich periplasmic protein OmcB
Short name:
Large-CRP
Alternative name(s):
60 kDa CRP
60 kDa outer membrane protein
Cysteine-rich outer membrane protein
Gene namesi
Name:omcB
Synonyms:omp2
Ordered Locus Names:CCA_00185
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000024886423 – 40Sequence analysisAdd BLAST18
ChainiPRO_000024886541 – 558Large cysteine-rich periplasmic protein OmcBAdd BLAST518

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP94664

Interactioni

Subunit structurei

Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB).By similarity

Protein-protein interaction databases

STRINGi227941.CCA00185

Structurei

3D structure databases

SMRiP94664
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 239Cys-richAdd BLAST42

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108U5Y Bacteria
ENOG4111GQD LUCA
OMAiCEAEFVS
OrthoDBiPOG091H14QO

Family and domain databases

InterProiView protein in InterPro
IPR003506 Chlam_OMP6
IPR001434 DUF11
PfamiView protein in Pfam
PF03504 Chlam_OMP6, 1 hit
PF01345 DUF11, 1 hit
PRINTSiPR01336 CHLAMIDIAOM6
TIGRFAMsiTIGR01451 B_ant_repeat, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLFRRVVT VLALTSMASS FASGKIEAAA AESLATRFIA SAENSDDNIS
60 70 80 90 100
QRKAKKVRFG RNKYQKQEQK NNGPYCDKEF YPCQDGSCQS SVDTKQEPCY
110 120 130 140 150
GKMYCVRVSD DSNVEISQAV PEYATVGSPY PIEILAVGKR DCVNVVITQQ
160 170 180 190 200
LPCEVEFISS DPATTPTSDS KLIWTIDRLG QGERCKITVW VKPLKEGCCF
210 220 230 240 250
TAATVCACPE LRSYTKCGQP AICIKQEGPE CACLRCPVCY KIEVTNTGSA
260 270 280 290 300
IARGVVVDNP VPDGYSHPSG QRVLSFNLGD MRPGDTKCFT VEFCPQKRGK
310 320 330 340 350
ITNVATVSYC GGHKCSANVT TVINEPCVQV NISGNDWSYV CKPVEYTIVV
360 370 380 390 400
SNPGDLKLYD VVIEDLIPSG ITILEAPGAE ICCNKAVWCI KEMCPGETLQ
410 420 430 440 450
FKVVAKAQTP GKFTNQVSVK TNSDCGSCTS CAEVTTHWKG LAATHMCVID
460 470 480 490 500
TNDPICVGEN TVYRICVTNR GSAEDTNVSL ILKFSKELQP VSSSGPTKGT
510 520 530 540 550
ITGNTVVFDA LPKLGSKESV EFSVTLKGVA PGDARGEAIL SSDTLTVPVA

DTENTHVY
Length:558
Mass (Da):60,214
Last modified:May 1, 1997 - v1
Checksum:i452E2BD79078935C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41759 Genomic DNA Translation: AAB41143.1
AE015925 Genomic DNA Translation: AAP04936.1
RefSeqiWP_011006157.1, NC_003361.3

Genome annotation databases

EnsemblBacteriaiAAP04936; AAP04936; CCA_00185
KEGGicca:CCA_00185

Similar proteinsi

Entry informationi

Entry nameiOMCB_CHLCV
AccessioniPrimary (citable) accession number: P94664
Secondary accession number(s): Q7BYF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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