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Protein

Large cysteine-rich periplasmic protein OmcB

Gene

omcB

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan. It is present but the disulfide bonds are reduced in reticulate bodies (RBs) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

BioCyciCCAV227941:GH8L-197-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Large cysteine-rich periplasmic protein OmcB
Short name:
Large-CRP
Alternative name(s):
60 kDa CRP
60 kDa outer membrane protein
Cysteine-rich outer membrane protein
Gene namesi
Name:omcB
Synonyms:omp2
Ordered Locus Names:CCA_00185
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000002193 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 4018Sequence analysisPRO_0000248864Add
BLAST
Chaini41 – 558518Large cysteine-rich periplasmic protein OmcBPRO_0000248865Add
BLAST

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Part of a disulfide cross-linked outer membrane complex (COMC) composed of the major outer membrane porin (MOMP), the small cysteine-rich protein (OmcA) and the large cysteine-rich periplasmic protein (OmcB).By similarity

Protein-protein interaction databases

STRINGi227941.CCA00185.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 23942Cys-richAdd
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108U5Y. Bacteria.
ENOG4111GQD. LUCA.
OMAiCEAEFVS.
OrthoDBiEOG6JTC5T.

Family and domain databases

InterProiIPR003506. Chlam_OMP6.
IPR001434. DUF11.
[Graphical view]
PfamiPF03504. Chlam_OMP6. 1 hit.
PF01345. DUF11. 2 hits.
[Graphical view]
PRINTSiPR01336. CHLAMIDIAOM6.
TIGRFAMsiTIGR01451. B_ant_repeat. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLFRRVVT VLALTSMASS FASGKIEAAA AESLATRFIA SAENSDDNIS
60 70 80 90 100
QRKAKKVRFG RNKYQKQEQK NNGPYCDKEF YPCQDGSCQS SVDTKQEPCY
110 120 130 140 150
GKMYCVRVSD DSNVEISQAV PEYATVGSPY PIEILAVGKR DCVNVVITQQ
160 170 180 190 200
LPCEVEFISS DPATTPTSDS KLIWTIDRLG QGERCKITVW VKPLKEGCCF
210 220 230 240 250
TAATVCACPE LRSYTKCGQP AICIKQEGPE CACLRCPVCY KIEVTNTGSA
260 270 280 290 300
IARGVVVDNP VPDGYSHPSG QRVLSFNLGD MRPGDTKCFT VEFCPQKRGK
310 320 330 340 350
ITNVATVSYC GGHKCSANVT TVINEPCVQV NISGNDWSYV CKPVEYTIVV
360 370 380 390 400
SNPGDLKLYD VVIEDLIPSG ITILEAPGAE ICCNKAVWCI KEMCPGETLQ
410 420 430 440 450
FKVVAKAQTP GKFTNQVSVK TNSDCGSCTS CAEVTTHWKG LAATHMCVID
460 470 480 490 500
TNDPICVGEN TVYRICVTNR GSAEDTNVSL ILKFSKELQP VSSSGPTKGT
510 520 530 540 550
ITGNTVVFDA LPKLGSKESV EFSVTLKGVA PGDARGEAIL SSDTLTVPVA

DTENTHVY
Length:558
Mass (Da):60,214
Last modified:May 1, 1997 - v1
Checksum:i452E2BD79078935C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41759 Genomic DNA. Translation: AAB41143.1.
AE015925 Genomic DNA. Translation: AAP04936.1.
RefSeqiWP_011006157.1. NC_003361.3.

Genome annotation databases

EnsemblBacteriaiAAP04936; AAP04936; CCA_00185.
KEGGicca:CCA00185.
PATRICi20269386. VBIChlCav107360_0193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41759 Genomic DNA. Translation: AAB41143.1.
AE015925 Genomic DNA. Translation: AAP04936.1.
RefSeqiWP_011006157.1. NC_003361.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227941.CCA00185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP04936; AAP04936; CCA_00185.
KEGGicca:CCA00185.
PATRICi20269386. VBIChlCav107360_0193.

Phylogenomic databases

eggNOGiENOG4108U5Y. Bacteria.
ENOG4111GQD. LUCA.
OMAiCEAEFVS.
OrthoDBiEOG6JTC5T.

Enzyme and pathway databases

BioCyciCCAV227941:GH8L-197-MONOMER.

Family and domain databases

InterProiIPR003506. Chlam_OMP6.
IPR001434. DUF11.
[Graphical view]
PfamiPF03504. Chlam_OMP6. 1 hit.
PF01345. DUF11. 2 hits.
[Graphical view]
PRINTSiPR01336. CHLAMIDIAOM6.
TIGRFAMsiTIGR01451. B_ant_repeat. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the omp2 region of Chlamydia psittaci strain GPIC: structural and functional implications."
    Hsia R.-C., Bavoil P.M.
    Gene 176:155-162(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GPIC.
  2. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
    Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
    , Rank R.G., Bavoil P.M., Fraser C.M.
    Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GPIC.

Entry informationi

Entry nameiOMCB_CHLCV
AccessioniPrimary (citable) accession number: P94664
Secondary accession number(s): Q7BYF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was thought to be an outer membrane protein as it is part of a disulfide cross-linked complex that is insoluble in the detergent Sarkosyl; however based on experiments in C.psittaci it is likely to be periplasmic.Curated

Keywords - Technical termi

Complete proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.