P94633 (LYSE_CORGL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysine exporter protein

Gene names

Name:	lysE
Ordered Locus Names:	Cgl1262, cg1424

Organism

Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [Reference proteome] [HAMAP]

Taxonomic identifier

196627 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › Corynebacterium glutamicum

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the efflux of excess of L-lysine. This is necessary to control the intracellular L-lysine level. Ref.1
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the LysE/ArgO transporter (TC 2.A.75) family. [View classification]
Sequence caution	The sequence BAB98655.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	amino acid transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Lysine exporter protein		PRO_0000204157
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	66 – 86	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Transmembrane	213 – 233	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P94633 [UniParc]. Last modified August 14, 2001. Version 2. Checksum: F5FD9B1ACAD11D13	FASTA	233	25,082
	10 20 30 40 50 60 MEIFITGLLL GASLLLSIGP QNVLVIKQGI KREGLIAVLL VCLISDVFLF IAGTLGVDLL 70 80 90 100 110 120 SNAAPIVLDI MRWGGIAYLL WFAVMAAKDA MTNKVEAPQI IEETEPTVPD DTPLGGSAVA 130 140 150 160 170 180 TDTRNRVRVE VSVDKQRVWV KPMLMAIVLT WLNPNAYLDA FVFIGGVGAQ YGDTGRWIFA 190 200 210 220 230 AGAFAASLIW FPLVGFGAAA LSRPLSSPKV WRWINVVVAV VMTALAIKLM LMG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new type of transporter with a new type of cellular function: L-lysine export from Corynebacterium glutamicum." Vrljic M.M., Sahm H., Eggeling L. Mol. Microbiol. 22:815-826(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: R127.
[2]	"The Corynebacterium glutamicum genome: features and impacts on biotechnological processes." Ikeda M., Nakagawa S. Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
[3]	"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. , Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A. J. Biotechnol. 104:5-25(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X96471 Genomic DNA. Translation: CAA65324.2. BA000036 Genomic DNA. Translation: BAB98655.1. Different initiation. BX927151 Genomic DNA. Translation: CAF19965.1.
RefSeq	NP_600485.1. NC_003450.3. YP_225551.1. NC_006958.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	196627.cg1424.
Protein family/group databases
TCDB	2.A.75.1.1. L-lysine exporter (LysE) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB98655; BAB98655; BAB98655. CAF19965; CAF19965; cg1424.
GeneID	1019244. 3343730.
KEGG	cgb:cg1424. cgl:NCgl1214.
PATRIC	21494566. VBICorGlu203724_1239.
Phylogenomic databases
eggNOG	COG1279.
HOGENOM	HOG000122948.
KO	K06895.
OMA	MRYGGAA.
ProtClustDB	CLSK633306.
Enzyme and pathway databases
BioCyc	CGLU196627:GJDM-1247-MONOMER.
Family and domain databases
InterPro	IPR004777. Lys/arg_exporter. IPR001123. LysE-type. [Graphical view]
Pfam	PF01810. LysE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00948. 2a75. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYSE_CORGL

Accession

Primary (citable) accession number: P94633

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	August 14, 2001
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program