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P94598

- DHE3_BACTN

UniProt

P94598 - DHE3_BACTN

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Protein

Glutamate dehydrogenase

Gene

gdhA

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei124 – 1241PROSITE-ProRule annotation

GO - Molecular functioni

  1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-2009-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase (EC:1.4.1.3)
Short name:
GDH
Alternative name(s):
NAD(P)H-utilizing glutamate dehydrogenase
Gene namesi
Name:gdhA
Ordered Locus Names:BT_1970
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Glutamate dehydrogenasePRO_0000182766Add
BLAST

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi226186.BT_1970.

Structurei

3D structure databases

ProteinModelPortaliP94598.
SMRiP94598. Positions 4-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243799.
InParanoidiP94598.
KOiK00262.
OMAiTANEYEV.
OrthoDBiEOG65XN4D.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94598-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAAKVLDDL KRRFPNEPEY HQAVEEVLST IEEEYNKHPE FDKANLIERL
60 70 80 90 100
CIPDRVFQFR VTWMDDKGNI QTNMGYRVQH NNAIGPYKGG IRFHASVNLS
110 120 130 140 150
ILKFLAFEQT FKNSLTTLPM GGGKGGSDFS PRGKSNAEVM RFVQAFMLEL
160 170 180 190 200
WRHIGPETDV PAGDIGVGGR EVGFMFGMYK KLAHEFTGTF TGKGREFGGS
210 220 230 240 250
LIRPEATGYG NIYFLMEMLK TKGTDLKGKV CLVSGSGNVA QYTIEKVIEL
260 270 280 290 300
GGKVVTCSDS DGYIYDPDGI DREKLDYIME LKNLYRGRIR EYAEKYGCKY
310 320 330 340 350
VEGAKPWGEK CDIALPSATQ NELNGDHARQ LVANGCIAVS EGANMPSTPE
360 370 380 390 400
AVRVFQDAKI LYAPGKAANA GGVSVSGLEM TQNSIKLSWS AEEVDEKLKS
410 420 430 440
IMKNIHEACV QYGTEADGYV NYVKGANVAG FMKVAKAMMA QGIV
Length:444
Mass (Da):49,017
Last modified:November 1, 1997 - v2
Checksum:i6563EB81F0746095
GO

Sequence cautioni

The sequence AAB40143.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82241 Genomic DNA. Translation: AAB40143.1. Different initiation.
AE015928 Genomic DNA. Translation: AAO77077.1.
RefSeqiNP_810883.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO77077; AAO77077; BT_1970.
GeneIDi1076144.
KEGGibth:BT_1970.
PATRICi21058859. VBIBacThe70966_2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82241 Genomic DNA. Translation: AAB40143.1 . Different initiation.
AE015928 Genomic DNA. Translation: AAO77077.1 .
RefSeqi NP_810883.1. NC_004663.1.

3D structure databases

ProteinModelPortali P94598.
SMRi P94598. Positions 4-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 226186.BT_1970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO77077 ; AAO77077 ; BT_1970 .
GeneIDi 1076144.
KEGGi bth:BT_1970.
PATRICi 21058859. VBIBacThe70966_2018.

Phylogenomic databases

eggNOGi COG0334.
HOGENOMi HOG000243799.
InParanoidi P94598.
KOi K00262.
OMAi TANEYEV.
OrthoDBi EOG65XN4D.

Enzyme and pathway databases

BioCyci BTHE226186:GJXV-2009-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The NAD(P)H-utilizing glutamate dehydrogenase of Bacteroides thetaiotaomicron belongs to enzyme family I, and its activity is affected by trans-acting gene(s) positioned downstream of gdhA."
    Baggio L., Morrison M.
    J. Bacteriol. 178:7212-7220(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
  2. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiDHE3_BACTN
AccessioniPrimary (citable) accession number: P94598
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3