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Protein

Glutamate dehydrogenase

Gene

gdhA

Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei124 – 1241PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-2009-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase (EC:1.4.1.3)
Short name:
GDH
Alternative name(s):
NAD(P)H-utilizing glutamate dehydrogenase
Gene namesi
Name:gdhA
Ordered Locus Names:BT_1970
OrganismiBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Taxonomic identifieri226186 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000001414 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Glutamate dehydrogenasePRO_0000182766Add
BLAST

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi226186.BT_1970.

Structurei

3D structure databases

ProteinModelPortaliP94598.
SMRiP94598. Positions 4-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243799.
InParanoidiP94598.
KOiK00262.
OMAiVTWMDDK.
OrthoDBiEOG65XN4D.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAKVLDDL KRRFPNEPEY HQAVEEVLST IEEEYNKHPE FDKANLIERL
60 70 80 90 100
CIPDRVFQFR VTWMDDKGNI QTNMGYRVQH NNAIGPYKGG IRFHASVNLS
110 120 130 140 150
ILKFLAFEQT FKNSLTTLPM GGGKGGSDFS PRGKSNAEVM RFVQAFMLEL
160 170 180 190 200
WRHIGPETDV PAGDIGVGGR EVGFMFGMYK KLAHEFTGTF TGKGREFGGS
210 220 230 240 250
LIRPEATGYG NIYFLMEMLK TKGTDLKGKV CLVSGSGNVA QYTIEKVIEL
260 270 280 290 300
GGKVVTCSDS DGYIYDPDGI DREKLDYIME LKNLYRGRIR EYAEKYGCKY
310 320 330 340 350
VEGAKPWGEK CDIALPSATQ NELNGDHARQ LVANGCIAVS EGANMPSTPE
360 370 380 390 400
AVRVFQDAKI LYAPGKAANA GGVSVSGLEM TQNSIKLSWS AEEVDEKLKS
410 420 430 440
IMKNIHEACV QYGTEADGYV NYVKGANVAG FMKVAKAMMA QGIV
Length:444
Mass (Da):49,017
Last modified:November 1, 1997 - v2
Checksum:i6563EB81F0746095
GO

Sequence cautioni

The sequence AAB40143.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82241 Genomic DNA. Translation: AAB40143.1. Different initiation.
AE015928 Genomic DNA. Translation: AAO77077.1.
RefSeqiNP_810883.1. NC_004663.1.
WP_011108072.1. NC_004663.1.

Genome annotation databases

EnsemblBacteriaiAAO77077; AAO77077; BT_1970.
GeneIDi1076144.
KEGGibth:BT_1970.
PATRICi21058859. VBIBacThe70966_2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82241 Genomic DNA. Translation: AAB40143.1. Different initiation.
AE015928 Genomic DNA. Translation: AAO77077.1.
RefSeqiNP_810883.1. NC_004663.1.
WP_011108072.1. NC_004663.1.

3D structure databases

ProteinModelPortaliP94598.
SMRiP94598. Positions 4-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226186.BT_1970.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO77077; AAO77077; BT_1970.
GeneIDi1076144.
KEGGibth:BT_1970.
PATRICi21058859. VBIBacThe70966_2018.

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243799.
InParanoidiP94598.
KOiK00262.
OMAiVTWMDDK.
OrthoDBiEOG65XN4D.

Enzyme and pathway databases

BioCyciBTHE226186:GJXV-2009-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The NAD(P)H-utilizing glutamate dehydrogenase of Bacteroides thetaiotaomicron belongs to enzyme family I, and its activity is affected by trans-acting gene(s) positioned downstream of gdhA."
    Baggio L., Morrison M.
    J. Bacteriol. 178:7212-7220(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
  2. "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis."
    Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.
    Science 299:2074-2076(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Entry informationi

Entry nameiDHE3_BACTN
AccessioniPrimary (citable) accession number: P94598
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.