Reviewed, UniProtKB/Swiss-Prot P94598 (DHE3_BACTN)

Names and origin

Protein names

Recommended name:
    Glutamate dehydrogenase
      Short name=GDH
    EC=1.4.1.3
Alternative name(s):
    NAD(P)H-utilizing glutamate dehydrogenase

Gene names

Name:	gdhA
Ordered Locus Names:	BT_1970

Organism

Bacteroides thetaiotaomicron [Complete proteome] [HAMAP]

Taxonomic identifier

818 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H.
Subunit structure	Homohexamer By similarity.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glutamate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Glutamate dehydrogenase		PRO_0000182766
Sites
	Active site	124	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P94598-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 6563EB81F0746095	FASTA	444	49,017
	10 20 30 40 50 60 MNAAKVLDDL KRRFPNEPEY HQAVEEVLST IEEEYNKHPE FDKANLIERL CIPDRVFQFR 70 80 90 100 110 120 VTWMDDKGNI QTNMGYRVQH NNAIGPYKGG IRFHASVNLS ILKFLAFEQT FKNSLTTLPM 130 140 150 160 170 180 GGGKGGSDFS PRGKSNAEVM RFVQAFMLEL WRHIGPETDV PAGDIGVGGR EVGFMFGMYK 190 200 210 220 230 240 KLAHEFTGTF TGKGREFGGS LIRPEATGYG NIYFLMEMLK TKGTDLKGKV CLVSGSGNVA 250 260 270 280 290 300 QYTIEKVIEL GGKVVTCSDS DGYIYDPDGI DREKLDYIME LKNLYRGRIR EYAEKYGCKY 310 320 330 340 350 360 VEGAKPWGEK CDIALPSATQ NELNGDHARQ LVANGCIAVS EGANMPSTPE AVRVFQDAKI 370 380 390 400 410 420 LYAPGKAANA GGVSVSGLEM TQNSIKLSWS AEEVDEKLKS IMKNIHEACV QYGTEADGYV 430 440 NYVKGANVAG FMKVAKAMMA QGIV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The NAD(P)H-utilizing glutamate dehydrogenase of Bacteroides thetaiotaomicron belongs to enzyme family I, and its activity is affected by trans-acting gene(s) positioned downstream of gdhA." Baggio L., Morrison M. J. Bacteriol. 178:7212-7220(1996) [PubMed: 8955404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.
[2]	"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis." Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I. Science 299:2074-2076(2003) [PubMed: 12663928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U82241 Genomic DNA. Translation: AAB40143.1. Different initiation. AE015928 Genomic DNA. Translation: AAO77077.1.
RefSeq	NP_810883.1.
3D structure databases
HSSP	HSSP built from PDB template 1AUP based on UniProtKB P24295.
ModBase	Search...
Genome annotation databases
GeneID	1076144.
GenomeReviews	Gene locus BT_1970 in contig AE015928_GR.
KEGG	bth:BT_1970.
NMPDR	fig|226186.1.peg.1970.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P94598.
Enzyme and pathway databases
BioCyc	BTHE226186:BT_1970-MON.
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DHase. IPR006096. Glu/Leu/Phe/Val_DHase_C. IPR006097. Glu/Leu/Phe/Val_DHase_dimer. IPR014362. Glu_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11606:SF2. GLFV_DH. 1 hit.
Pfam	PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view]
PIRSF	PIRSF000185. Glu_DH. 1 hit.
PRINTS	PR00082. GLFDHDRGNASE.
PROSITE	PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHE3_BACTN

Accession

Primary (citable) accession number: P94598

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)