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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 4 nanosiemens. May participate in the regulation of osmotic pressure changes within the cell.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU36360-MONOMER.

Protein family/group databases

TCDBi1.A.22.1.3. the large conductance mechanosensitive ion channel (mscl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Synonyms:ywpC
Ordered Locus Names:BSU36360
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotationBy similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicBy similarityAdd BLAST14
Transmembranei15 – 43HelicalBy similarityAdd BLAST29
Topological domaini44 – 65ExtracellularBy similarityAdd BLAST22
Transmembranei66 – 85HelicalBy similarityAdd BLAST20
Topological domaini86 – 130CytoplasmicBy similarityAdd BLAST45

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001924331 – 130Large-conductance mechanosensitive channelAdd BLAST130

Proteomic databases

PaxDbiP94585.

Interactioni

Subunit structurei

Homopentamer.UniRule annotationBy similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019661.

Structurei

3D structure databases

ProteinModelPortaliP94585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105M2E. Bacteria.
COG1970. LUCA.
HOGENOMiHOG000226782.
InParanoidiP94585.
KOiK03282.
OMAiYGSFIQT.
PhylomeDBiP94585.

Family and domain databases

HAMAPiMF_00115. MscL. 1 hit.
InterProiView protein in InterPro
IPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
PANTHERiPTHR30266:SF3. PTHR30266:SF3. 1 hit.
PfamiView protein in Pfam
PF01741. MscL. 1 hit.
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiView protein in PROSITE
PS01327. MSCL. 1 hit.

Sequencei

Sequence statusi: Complete.

P94585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNEFKAFAM RGNIVDLAIG VVIGGAFGKI VTSLVNDIIM PLVGLLLGGL
60 70 80 90 100
DFSGLSFTFG DAVVKYGSFI QTIVNFLIIS FSIFIVIRTL NGLRRKKEAE
110 120 130
EEAAEEAVDA QEELLKEIRD LLKQQAKSPE
Length:130
Mass (Da):14,280
Last modified:May 1, 1997 - v1
Checksum:i0941C01C2AAA8A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83337 Genomic DNA. Translation: CAB05944.1.
AL009126 Genomic DNA. Translation: CAB15653.1.
PIRiE70065.
RefSeqiNP_391517.1. NC_000964.3.
WP_003242893.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB15653; CAB15653; BSU36360.
GeneIDi936909.
KEGGibsu:BSU36360.
PATRICifig|224308.43.peg.3811.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMSCL_BACSU
AccessioniPrimary (citable) accession number: P94585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: July 5, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families