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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU36360-MONOMER.

Protein family/group databases

TCDBi1.A.22.1.3. the large conductance mechanosensitive ion channel (mscl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channel
Gene namesi
Name:mscL
Synonyms:ywpC
Ordered Locus Names:BSU36360
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 40HelicalSequence analysisAdd BLAST27
Topological domaini41 – 65ExtracellularSequence analysisAdd BLAST25
Transmembranei66 – 87HelicalSequence analysisAdd BLAST22
Topological domaini88 – 130CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001924331 – 130Large-conductance mechanosensitive channelAdd BLAST130

Proteomic databases

PaxDbiP94585.

Interactioni

Subunit structurei

Homopentamer.By similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019661.

Structurei

3D structure databases

ProteinModelPortaliP94585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105M2E. Bacteria.
COG1970. LUCA.
HOGENOMiHOG000226782.
InParanoidiP94585.
KOiK03282.
OMAiFHWVLRE.
PhylomeDBiP94585.

Family and domain databases

HAMAPiMF_00115. MscL. 1 hit.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNEFKAFAM RGNIVDLAIG VVIGGAFGKI VTSLVNDIIM PLVGLLLGGL
60 70 80 90 100
DFSGLSFTFG DAVVKYGSFI QTIVNFLIIS FSIFIVIRTL NGLRRKKEAE
110 120 130
EEAAEEAVDA QEELLKEIRD LLKQQAKSPE
Length:130
Mass (Da):14,280
Last modified:May 1, 1997 - v1
Checksum:i0941C01C2AAA8A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83337 Genomic DNA. Translation: CAB05944.1.
AL009126 Genomic DNA. Translation: CAB15653.1.
PIRiE70065.
RefSeqiNP_391517.1. NC_000964.3.
WP_003242893.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15653; CAB15653; BSU36360.
GeneIDi936909.
KEGGibsu:BSU36360.
PATRICi18979298. VBIBacSub10457_3811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83337 Genomic DNA. Translation: CAB05944.1.
AL009126 Genomic DNA. Translation: CAB15653.1.
PIRiE70065.
RefSeqiNP_391517.1. NC_000964.3.
WP_003242893.1. NC_000964.3.

3D structure databases

ProteinModelPortaliP94585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100019661.

Protein family/group databases

TCDBi1.A.22.1.3. the large conductance mechanosensitive ion channel (mscl) family.

Proteomic databases

PaxDbiP94585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15653; CAB15653; BSU36360.
GeneIDi936909.
KEGGibsu:BSU36360.
PATRICi18979298. VBIBacSub10457_3811.

Phylogenomic databases

eggNOGiENOG4105M2E. Bacteria.
COG1970. LUCA.
HOGENOMiHOG000226782.
InParanoidiP94585.
KOiK03282.
OMAiFHWVLRE.
PhylomeDBiP94585.

Enzyme and pathway databases

BioCyciBSUB:BSU36360-MONOMER.

Family and domain databases

HAMAPiMF_00115. MscL. 1 hit.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSCL_BACSU
AccessioniPrimary (citable) accession number: P94585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: October 5, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.