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Protein

Glutamate racemase 1

Gene

racE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Proton donor/acceptorUniRule annotationBy similarity
Active sitei185 – 1851Proton donor/acceptorUniRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBSUB:BSU28390-MONOMER.
BRENDAi5.1.1.3. 658.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemase 1UniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:racE
Synonyms:glr, murI
Ordered Locus Names:BSU28390
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Glutamate racemase 1PRO_0000095453Add
BLAST

Proteomic databases

PaxDbiP94556.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100015506.

Structurei

Secondary structure

1
272
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 138Combined sources
Helixi16 – 2510Combined sources
Beta strandi31 – 355Combined sources
Helixi37 – 393Combined sources
Beta strandi43 – 453Combined sources
Helixi47 – 6418Combined sources
Beta strandi68 – 725Combined sources
Helixi75 – 8814Combined sources
Beta strandi93 – 964Combined sources
Helixi97 – 10711Combined sources
Beta strandi109 – 1179Combined sources
Helixi119 – 1235Combined sources
Helixi126 – 1349Combined sources
Beta strandi139 – 1446Combined sources
Helixi148 – 1525Combined sources
Helixi159 – 17517Combined sources
Beta strandi179 – 1857Combined sources
Helixi188 – 1914Combined sources
Helixi192 – 1998Combined sources
Beta strandi203 – 2075Combined sources
Helixi208 – 22316Combined sources
Beta strandi235 – 2417Combined sources
Helixi243 – 25311Combined sources
Beta strandi261 – 2633Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZUWX-ray1.75A/B/C1-272[»]
ProteinModelPortaliP94556.
SMRiP94556. Positions 2-268.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP94556.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 112Substrate bindingUniRule annotationCombined sources1 Publication
Regioni42 – 432Substrate bindingUniRule annotationCombined sources1 Publication
Regioni75 – 762Substrate bindingUniRule annotationCombined sources1 Publication
Regioni186 – 1872Substrate bindingUniRule annotationCombined sources1 Publication

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
InParanoidiP94556.
KOiK01776.
OMAiELLETCM.
PhylomeDBiP94556.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEQPIGVID SGVGGLTVAK EIMRQLPKEN IIYVGDTKRC PYGPRPEEEV
60 70 80 90 100
LQYTWELTNY LLENHHIKML VIACNTATAI ALDDIQRSVG IPVVGVIQPG
110 120 130 140 150
ARAAIKVTDN QHIGVIGTEN TIKSNAYEEA LLALNPDLKV ENLACPLLVP
160 170 180 190 200
FVESGKFLDK TADEIVKTSL YPLKDTSIDS LILGCTHYPI LKEAIQRYMG
210 220 230 240 250
EHVNIISSGD ETAREVSTIL SYKGLLNQSP IAPDHQFLTT GARDQFAKIA
260 270
DDWFGHEVGH VECISLQEPI KR
Length:272
Mass (Da):29,998
Last modified:July 7, 2009 - v2
Checksum:i97489B93A48471FA
GO

Sequence cautioni

The sequence BAA28871 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601K → Q in CAA99552 (PubMed:8969504).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75208 Genomic DNA. Translation: CAA99552.1.
AL009126 Genomic DNA. Translation: CAB14799.2.
AB003685 Genomic DNA. Translation: BAA28871.1. Different initiation.
PIRiB69688.
RefSeqiNP_390717.2. NC_000964.3.
WP_010886589.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14799; CAB14799; BSU28390.
GeneIDi935934.
KEGGibsu:BSU28390.
PATRICi18977562. VBIBacSub10457_2969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75208 Genomic DNA. Translation: CAA99552.1.
AL009126 Genomic DNA. Translation: CAB14799.2.
AB003685 Genomic DNA. Translation: BAA28871.1. Different initiation.
PIRiB69688.
RefSeqiNP_390717.2. NC_000964.3.
WP_010886589.1. NC_000964.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZUWX-ray1.75A/B/C1-272[»]
ProteinModelPortaliP94556.
SMRiP94556. Positions 2-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100015506.

Proteomic databases

PaxDbiP94556.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14799; CAB14799; BSU28390.
GeneIDi935934.
KEGGibsu:BSU28390.
PATRICi18977562. VBIBacSub10457_2969.

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
InParanoidiP94556.
KOiK01776.
OMAiELLETCM.
PhylomeDBiP94556.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciBSUB:BSU28390-MONOMER.
BRENDAi5.1.1.3. 658.

Miscellaneous databases

EvolutionaryTraceiP94556.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURI1_BACSU
AccessioniPrimary (citable) accession number: P94556
Secondary accession number(s): O82826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 7, 2009
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.