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Protein

Glutamate racemase 1

Gene

racE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Proton donor/acceptorUniRule annotationBy similarity1
Active sitei185Proton donor/acceptorUniRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBSUB:BSU28390-MONOMER
BRENDAi5.1.1.3 658
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemase 1UniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:racE
Synonyms:glr, murI
Ordered Locus Names:BSU28390
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000954531 – 272Glutamate racemase 1Add BLAST272

Proteomic databases

PaxDbiP94556

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100015506

Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 13Combined sources8
Helixi16 – 25Combined sources10
Beta strandi31 – 35Combined sources5
Helixi37 – 39Combined sources3
Beta strandi43 – 45Combined sources3
Helixi47 – 64Combined sources18
Beta strandi68 – 72Combined sources5
Helixi75 – 88Combined sources14
Beta strandi93 – 96Combined sources4
Helixi97 – 107Combined sources11
Beta strandi109 – 117Combined sources9
Helixi119 – 123Combined sources5
Helixi126 – 134Combined sources9
Beta strandi139 – 144Combined sources6
Helixi148 – 152Combined sources5
Helixi159 – 175Combined sources17
Beta strandi179 – 185Combined sources7
Helixi188 – 191Combined sources4
Helixi192 – 199Combined sources8
Beta strandi203 – 207Combined sources5
Helixi208 – 223Combined sources16
Beta strandi235 – 241Combined sources7
Helixi243 – 253Combined sources11
Beta strandi261 – 263Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUWX-ray1.75A/B/C1-272[»]
ProteinModelPortaliP94556
SMRiP94556
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP94556

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 11Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni42 – 43Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni75 – 76Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni186 – 187Substrate bindingUniRule annotationCombined sources1 Publication2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03 Bacteria
COG0796 LUCA
HOGENOMiHOG000262396
InParanoidiP94556
KOiK01776
OMAiVYGCTHY
PhylomeDBiP94556

Family and domain databases

HAMAPiMF_00258 Glu_racemase, 1 hit
InterProiView protein in InterPro
IPR015942 Asp/Glu/hydantoin_racemase
IPR001920 Asp/Glu_race
IPR018187 Asp/Glu_racemase_AS_1
IPR033134 Asp/Glu_racemase_AS_2
IPR004391 Glu_race
PANTHERiPTHR21198:SF2 PTHR21198:SF2, 1 hit
PfamiView protein in Pfam
PF01177 Asp_Glu_race, 1 hit
SUPFAMiSSF53681 SSF53681, 2 hits
TIGRFAMsiTIGR00067 glut_race, 1 hit
PROSITEiView protein in PROSITE
PS00923 ASP_GLU_RACEMASE_1, 1 hit
PS00924 ASP_GLU_RACEMASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P94556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEQPIGVID SGVGGLTVAK EIMRQLPKEN IIYVGDTKRC PYGPRPEEEV
60 70 80 90 100
LQYTWELTNY LLENHHIKML VIACNTATAI ALDDIQRSVG IPVVGVIQPG
110 120 130 140 150
ARAAIKVTDN QHIGVIGTEN TIKSNAYEEA LLALNPDLKV ENLACPLLVP
160 170 180 190 200
FVESGKFLDK TADEIVKTSL YPLKDTSIDS LILGCTHYPI LKEAIQRYMG
210 220 230 240 250
EHVNIISSGD ETAREVSTIL SYKGLLNQSP IAPDHQFLTT GARDQFAKIA
260 270
DDWFGHEVGH VECISLQEPI KR
Length:272
Mass (Da):29,998
Last modified:July 7, 2009 - v2
Checksum:i97489B93A48471FA
GO

Sequence cautioni

The sequence BAA28871 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160K → Q in CAA99552 (PubMed:8969504).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75208 Genomic DNA Translation: CAA99552.1
AL009126 Genomic DNA Translation: CAB14799.2
AB003685 Genomic DNA Translation: BAA28871.1 Different initiation.
PIRiB69688
RefSeqiNP_390717.2, NC_000964.3
WP_010886589.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14799; CAB14799; BSU28390
GeneIDi935934
KEGGibsu:BSU28390
PATRICifig|224308.43.peg.2969

Similar proteinsi

Entry informationi

Entry nameiMURI1_BACSU
AccessioniPrimary (citable) accession number: P94556
Secondary accession number(s): O82826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health