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Protein

Fatty acid metabolism regulator protein

Gene

fadR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator in fatty acid degradation. Represses transcription of genes required for fatty acid transport and beta-oxidation, including acdA, fadA, fadB, fadE, fadF, fadG, fadH, fadM, fadN, lcfA and lcfB. Binding of FadR to DNA is specifically inhibited by long chain fatty acyl-CoA compounds of 14-20 carbon atoms in length.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 47H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU28550-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid metabolism regulator protein
Gene namesi
Name:fadR
Synonyms:ysiA
Ordered Locus Names:BSU28550
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB03264 Dodecyl-Coa

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003606741 – 194Fatty acid metabolism regulator proteinAdd BLAST194

Proteomic databases

PaxDbiP94548
PRIDEiP94548

Interactioni

Subunit structurei

Homodimer. Binds to DNA.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100015586

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 22Combined sources16
Helixi24 – 26Combined sources3
Helixi29 – 36Combined sources8
Helixi40 – 46Combined sources7
Helixi50 – 73Combined sources24
Helixi79 – 95Combined sources17
Helixi98 – 105Combined sources8
Turni106 – 108Combined sources3
Helixi113 – 139Combined sources27
Beta strandi141 – 143Combined sources3
Helixi149 – 169Combined sources21
Turni170 – 172Combined sources3
Helixi176 – 179Combined sources4
Helixi180 – 189Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VI0X-ray1.65A/B2-194[»]
3WHBX-ray2.15A/B1-194[»]
3WHCX-ray2.20A/B/C/D/E/F1-194[»]
ProteinModelPortaliP94548
SMRiP94548
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP94548

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 65HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4107Z3H Bacteria
ENOG411032B LUCA
HOGENOMiHOG000012954
InParanoidiP94548
KOiK13770
OMAiRQQFAFI
PhylomeDBiP94548

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR036271 Tet_transcr_reg_TetR-rel_C_sf
IPR013570 Tscrpt_reg_YsiA_C
PfamiView protein in Pfam
PF08359 TetR_C_4, 1 hit
PF00440 TetR_N, 1 hit
PRINTSiPR00455 HTHTETR
SUPFAMiSSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS50977 HTH_TETR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P94548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQKRPKYMQ IIDAAVEVIA ENGYHQSQVS KIAKQAGVAD GTIYLYFKNK
60 70 80 90 100
EDILISLFKE KMGQFIERME EDIKEKATAK EKLALVISKH FSLLAGDHNL
110 120 130 140 150
AIVTQLELRQ SNLELRQKIN EILKGYLNIL DGILTEGIQS GEIKEGLDVR
160 170 180 190
LARQMIFGTI DETVTTWVMN DQKYDLVALS NSVLELLVSG IHNK
Length:194
Mass (Da):21,979
Last modified:May 1, 1997 - v1
Checksum:iA8C01C9C3B47CFE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75208 Genomic DNA Translation: CAA99572.1
AL009126 Genomic DNA Translation: CAB14815.1
PIRiF69985
RefSeqiNP_390733.1, NC_000964.3
WP_003229547.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14815; CAB14815; BSU28550
GeneIDi938105
KEGGibsu:BSU28550
PATRICifig|224308.179.peg.3102

Similar proteinsi

Entry informationi

Entry nameiFADR_BACSU
AccessioniPrimary (citable) accession number: P94548
Secondary accession number(s): Q795X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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