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Reviewed, UniProtKB/Swiss-Prot P94547 (LCFA_BACSU)

Last modified November 3, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Long-chain-fatty-acid--CoA ligase
    EC=6.2.1.3
Alternative name(s):
    Long-chain acyl-CoA synthetase
Gene names
Name: lcfA
Ordered Locus Names: BSU28560
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

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Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfatty acid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain-fatty-acid-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Long-chain-fatty-acid--CoA ligase
PRO_0000193124

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Sequences

Sequence LengthMass (Da)Tools
P94547-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 416A664E5926C7EA

FASTA56062,692
        10         20         30         40         50         60 
MQSQKPWLAE YPNDIPHELP LPNKTLQSIL TDSAARFPDK TAISFYGKKL TFHDILTDAL 

        70         80         90        100        110        120 
KLAAFLQCNG LQKGDRVAVM LPNCPQTVIS YYGVLFAGGI VVQTNPLYTE HELEYQLRDA 

       130        140        150        160        170        180 
QVSVIITLDL LFPKAIKMKT LSIVDQILIT SVKDYLPFPK NILYPLTQKQ KVHIDFDKTA 

       190        200        210        220        230        240 
NIHTFASCMK QEKTELLTIP KIDPEHDIAV LQYTGGTTGA PKGVMLTHQN ILANTEMCAA 

       250        260        270        280        290        300 
WMYDVKEGAE KVLGIVPFFH VYGLTAVMNY SIKLGFEMIL LPKFDPLETL KIIDKHKPTL 

       310        320        330        340        350        360 
FPGAPTIYIG LLHHPELQHY DLSSIKSCLS GSAALPVEVK QKFEKVTGGK LVEGYGLSEA 

       370        380        390        400        410        420 
SPVTHANFIW GKNKPGSIGC PWPSTDAAIY SEETGELAAP YEHGEIIVKG PQVMKGYWNK 

       430        440        450        460        470        480 
PEETAAVLRD GWLFTGDMGY MDEEGFFYIA DRKKDIIIAG GYNIYPREVE EALYEHEAIQ 

       490        500        510        520        530        540 
EIVVAGVPDS YRGETVKAFV VLKKGAKADT EELDAFARSR LAPYKVPKAY EFRKELPKTA 

       550        560 
VGKILRRRLL EEETENHHIK

« Hide

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References

« Hide 'large scale' references
[1]"The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism."
Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J., Emmerson P.T., Harwood C.R.
Microbiology 142:3067-3078(1996) [PubMed: 8969504] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

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Cross-references

Sequence databases

Z75208 Genomic DNA. Translation: CAA99571.1.
AL009126 Genomic DNA. Translation: CAB14816.1.
PIRD69649.
RefSeqNP_390734.1.

3D structure databases

HSSPHSSP built from PDB template 1LCI based on UniProtKB P08659.
ModBaseSearch...

Genome annotation databases

GeneID936505.
GenomeReviewsGene locus BSU28560 in contig AL009126_GR.
KEGGbsu:BSU28560.
NMPDRfig|224308.1.peg.2859.

Organism-specific databases

SubtiListBG11946. lcfA. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP94547.
OMAIVTRIAD.

Enzyme and pathway databases

BioCycBSUB224308:BSU2852-MON.
BRENDA6.2.1.3. 150.

Family and domain databases

InterProIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLCFA_BACSU
AccessionPrimary (citable) accession number: P94547
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents