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P94547

- LCFA_BACSU

UniProt

P94547 - LCFA_BACSU

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Protein

Long-chain-fatty-acid--CoA ligase

Gene

lcfA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU28560-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene namesi
Name:lcfA
Ordered Locus Names:BSU28560
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU28560. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Long-chain-fatty-acid--CoA ligasePRO_0000193124Add
BLAST

Proteomic databases

PaxDbiP94547.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU28560.

Structurei

3D structure databases

ProteinModelPortaliP94547.
SMRiP94547. Positions 18-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000229983.
InParanoidiP94547.
KOiK01897.
OMAiYKMILLP.
OrthoDBiEOG6MH5BV.
PhylomeDBiP94547.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94547-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSQKPWLAE YPNDIPHELP LPNKTLQSIL TDSAARFPDK TAISFYGKKL
60 70 80 90 100
TFHDILTDAL KLAAFLQCNG LQKGDRVAVM LPNCPQTVIS YYGVLFAGGI
110 120 130 140 150
VVQTNPLYTE HELEYQLRDA QVSVIITLDL LFPKAIKMKT LSIVDQILIT
160 170 180 190 200
SVKDYLPFPK NILYPLTQKQ KVHIDFDKTA NIHTFASCMK QEKTELLTIP
210 220 230 240 250
KIDPEHDIAV LQYTGGTTGA PKGVMLTHQN ILANTEMCAA WMYDVKEGAE
260 270 280 290 300
KVLGIVPFFH VYGLTAVMNY SIKLGFEMIL LPKFDPLETL KIIDKHKPTL
310 320 330 340 350
FPGAPTIYIG LLHHPELQHY DLSSIKSCLS GSAALPVEVK QKFEKVTGGK
360 370 380 390 400
LVEGYGLSEA SPVTHANFIW GKNKPGSIGC PWPSTDAAIY SEETGELAAP
410 420 430 440 450
YEHGEIIVKG PQVMKGYWNK PEETAAVLRD GWLFTGDMGY MDEEGFFYIA
460 470 480 490 500
DRKKDIIIAG GYNIYPREVE EALYEHEAIQ EIVVAGVPDS YRGETVKAFV
510 520 530 540 550
VLKKGAKADT EELDAFARSR LAPYKVPKAY EFRKELPKTA VGKILRRRLL
560
EEETENHHIK
Length:560
Mass (Da):62,692
Last modified:May 1, 1997 - v1
Checksum:i416A664E5926C7EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75208 Genomic DNA. Translation: CAA99571.1.
AL009126 Genomic DNA. Translation: CAB14816.1.
PIRiD69649.
RefSeqiNP_390734.1. NC_000964.3.
WP_004399166.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB14816; CAB14816; BSU28560.
GeneIDi936505.
KEGGibsu:BSU28560.
PATRICi18977600. VBIBacSub10457_2988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75208 Genomic DNA. Translation: CAA99571.1 .
AL009126 Genomic DNA. Translation: CAB14816.1 .
PIRi D69649.
RefSeqi NP_390734.1. NC_000964.3.
WP_004399166.1. NZ_CM000487.1.

3D structure databases

ProteinModelPortali P94547.
SMRi P94547. Positions 18-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU28560.

Proteomic databases

PaxDbi P94547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14816 ; CAB14816 ; BSU28560 .
GeneIDi 936505.
KEGGi bsu:BSU28560.
PATRICi 18977600. VBIBacSub10457_2988.

Organism-specific databases

GenoListi BSU28560. [Micado ]

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000229983.
InParanoidi P94547.
KOi K01897.
OMAi YKMILLP.
OrthoDBi EOG6MH5BV.
PhylomeDBi P94547.

Enzyme and pathway databases

BioCyci BSUB:BSU28560-MONOMER.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism."
    Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J., Emmerson P.T., Harwood C.R.
    Microbiology 142:3067-3078(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiLCFA_BACSU
AccessioniPrimary (citable) accession number: P94547
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3