Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P94545

- MUTS2_BACSU

UniProt

P94545 - MUTS2_BACSU

Protein

Endonuclease MutS2

Gene

mutSB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi335 – 3428ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. endonuclease activity Source: UniProtKB-HAMAP
    4. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: InterPro
    2. negative regulation of DNA recombination Source: InterPro

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU28580-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
    Gene namesi
    Name:mutSB
    Synonyms:mutS2, yshD
    Ordered Locus Names:BSU28580
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU28580. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 785785Endonuclease MutS2PRO_0000115217Add
    BLAST

    Proteomic databases

    PaxDbiP94545.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224308.BSU28580.

    Structurei

    3D structure databases

    ProteinModelPortaliP94545.
    SMRiP94545. Positions 407-457, 708-785.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini710 – 78576SmrUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation
    Contains 1 Smr domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1193.
    HOGENOMiHOG000135096.
    KOiK07456.
    OMAiFGGIVHD.
    OrthoDBiEOG6P5ZC4.
    PhylomeDBiP94545.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00092. MutS2.
    InterProiIPR000432. DNA_mismatch_repair_MutS_C.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR005747. MutS2.
    IPR027417. P-loop_NTPase.
    IPR002625. Smr/MutS2_C.
    [Graphical view]
    PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
    PfamiPF05192. MutS_III. 1 hit.
    PF00488. MutS_V. 1 hit.
    PF01713. Smr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005814. MutS_YshD. 1 hit.
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    SM00463. SMR. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01069. mutS2. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    PS50828. SMR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P94545-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQKVLSALE FHKVKEQVIG HAASSLGKEM LLELKPSASI DEIKKQLDEV    50
    DEASDIIRLR GQAPFGGLVD IRGALRRAEI GSVLSPSEFT EISGLLYAVK 100
    QMKHFITQMA EDGVDIPLIH QHAEQLITLS DLERDINSCI DDHGEVLDHA 150
    SETLRGIRTQ LRTLESRVRD RLESMLRSSS ASKMLSDTIV TIRNDRFVIP 200
    VKQEYRSSYG GIVHDTSSSG ATLFIEPQAI VDMNNSLQQA KVKEKQEIER 250
    ILRVLTEKTA EYTEELFLDL QVLQTLDFIF AKARYAKAVK ATKPIMNDTG 300
    FIRLKKARHP LLPPDQVVAN DIELGRDFST IVITGPNTGG KTVTLKTLGL 350
    LTLMAQSGLH IPADEGSEAA VFEHVFADIG DEQSIEQSLS TFSSHMVNIV 400
    GILEQVNENS LVLFDELGAG TDPQEGAALA MSILDDVHRT NARVLATTHY 450
    PELKAYGYNR EGVMNASVEF DIETLSPTYK LLIGVPGRSN AFEISKRLGL 500
    PDHIIGQAKS EMTAEHNEVD TMIASLEQSK KRAEEELSET ESIRKEAEKL 550
    HKELQQQIIE LNSKKDKMLE EAEQQAAEKV KAAMKEAEDI IHELRTIKEE 600
    HKSFKDHELI NAKKRLEGAM PAFEKSKKPE KPKTQKRDFK PGDEVKVLTF 650
    GQKGTLLEKT GGNEWNVQIG ILKMKVKEKD LEFIKSAPEP KKEKMITAVK 700
    GKDYHVSLEL DLRGERYENA LSRVEKYLDD AVLAGYPRVS IIHGKGTGAL 750
    RKGVQDLLKN HRSVKSSRFG EAGEGGSGVT VVELK 785
    Length:785
    Mass (Da):87,417
    Last modified:July 1, 1997 - v2
    Checksum:i20D14CDB931167C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75208 Genomic DNA. Translation: CAA99569.1.
    AL009126 Genomic DNA. Translation: CAB14818.1.
    PIRiD69985.
    RefSeqiNP_390736.1. NC_000964.3.
    WP_003229541.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB14818; CAB14818; BSU28580.
    GeneIDi937447.
    KEGGibsu:BSU28580.
    PATRICi18977604. VBIBacSub10457_2990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z75208 Genomic DNA. Translation: CAA99569.1 .
    AL009126 Genomic DNA. Translation: CAB14818.1 .
    PIRi D69985.
    RefSeqi NP_390736.1. NC_000964.3.
    WP_003229541.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali P94545.
    SMRi P94545. Positions 407-457, 708-785.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU28580.

    Proteomic databases

    PaxDbi P94545.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB14818 ; CAB14818 ; BSU28580 .
    GeneIDi 937447.
    KEGGi bsu:BSU28580.
    PATRICi 18977604. VBIBacSub10457_2990.

    Organism-specific databases

    GenoListi BSU28580. [Micado ]

    Phylogenomic databases

    eggNOGi COG1193.
    HOGENOMi HOG000135096.
    KOi K07456.
    OMAi FGGIVHD.
    OrthoDBi EOG6P5ZC4.
    PhylomeDBi P94545.

    Enzyme and pathway databases

    BioCyci BSUB:BSU28580-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00092. MutS2.
    InterProi IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR005747. MutS2.
    IPR027417. P-loop_NTPase.
    IPR002625. Smr/MutS2_C.
    [Graphical view ]
    PANTHERi PTHR11361:SF14. PTHR11361:SF14. 1 hit.
    Pfami PF05192. MutS_III. 1 hit.
    PF00488. MutS_V. 1 hit.
    PF01713. Smr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005814. MutS_YshD. 1 hit.
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    SM00463. SMR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01069. mutS2. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    PS50828. SMR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism."
      Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J., Emmerson P.T., Harwood C.R.
      Microbiology 142:3067-3078(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiMUTS2_BACSU
    AccessioniPrimary (citable) accession number: P94545
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3