SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P94545

- MUTS2_BACSU

UniProt

P94545 - MUTS2_BACSU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Endonuclease MutS2

Gene
mutSB, mutS2, yshD, BSU28580
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi335 – 3428ATP Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. endonuclease activity Source: UniProtKB-HAMAP
  4. mismatched DNA binding Source: InterPro

GO - Biological processi

  1. mismatch repair Source: InterPro
  2. negative regulation of DNA recombination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU28580-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease MutS2 (EC:3.1.-.-)
Gene namesi
Name:mutSB
Synonyms:mutS2, yshD
Ordered Locus Names:BSU28580
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU28580. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 785785Endonuclease MutS2UniRule annotationPRO_0000115217Add
BLAST

Proteomic databases

PaxDbiP94545.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224308.BSU28580.

Structurei

3D structure databases

ProteinModelPortaliP94545.
SMRiP94545. Positions 407-457, 708-785.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini710 – 78576SmrAdd
BLAST

Sequence similaritiesi

Contains 1 Smr domain.

Phylogenomic databases

eggNOGiCOG1193.
HOGENOMiHOG000135096.
KOiK07456.
OMAiFGGIVHD.
OrthoDBiEOG6P5ZC4.
PhylomeDBiP94545.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00092. MutS2.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamiPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFiPIRSF005814. MutS_YshD. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01069. mutS2. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94545-1 [UniParc]FASTAAdd to Basket

« Hide

MQQKVLSALE FHKVKEQVIG HAASSLGKEM LLELKPSASI DEIKKQLDEV    50
DEASDIIRLR GQAPFGGLVD IRGALRRAEI GSVLSPSEFT EISGLLYAVK 100
QMKHFITQMA EDGVDIPLIH QHAEQLITLS DLERDINSCI DDHGEVLDHA 150
SETLRGIRTQ LRTLESRVRD RLESMLRSSS ASKMLSDTIV TIRNDRFVIP 200
VKQEYRSSYG GIVHDTSSSG ATLFIEPQAI VDMNNSLQQA KVKEKQEIER 250
ILRVLTEKTA EYTEELFLDL QVLQTLDFIF AKARYAKAVK ATKPIMNDTG 300
FIRLKKARHP LLPPDQVVAN DIELGRDFST IVITGPNTGG KTVTLKTLGL 350
LTLMAQSGLH IPADEGSEAA VFEHVFADIG DEQSIEQSLS TFSSHMVNIV 400
GILEQVNENS LVLFDELGAG TDPQEGAALA MSILDDVHRT NARVLATTHY 450
PELKAYGYNR EGVMNASVEF DIETLSPTYK LLIGVPGRSN AFEISKRLGL 500
PDHIIGQAKS EMTAEHNEVD TMIASLEQSK KRAEEELSET ESIRKEAEKL 550
HKELQQQIIE LNSKKDKMLE EAEQQAAEKV KAAMKEAEDI IHELRTIKEE 600
HKSFKDHELI NAKKRLEGAM PAFEKSKKPE KPKTQKRDFK PGDEVKVLTF 650
GQKGTLLEKT GGNEWNVQIG ILKMKVKEKD LEFIKSAPEP KKEKMITAVK 700
GKDYHVSLEL DLRGERYENA LSRVEKYLDD AVLAGYPRVS IIHGKGTGAL 750
RKGVQDLLKN HRSVKSSRFG EAGEGGSGVT VVELK 785
Length:785
Mass (Da):87,417
Last modified:July 1, 1997 - v2
Checksum:i20D14CDB931167C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75208 Genomic DNA. Translation: CAA99569.1.
AL009126 Genomic DNA. Translation: CAB14818.1.
PIRiD69985.
RefSeqiNP_390736.1. NC_000964.3.
WP_003229541.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB14818; CAB14818; BSU28580.
GeneIDi937447.
KEGGibsu:BSU28580.
PATRICi18977604. VBIBacSub10457_2990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z75208 Genomic DNA. Translation: CAA99569.1 .
AL009126 Genomic DNA. Translation: CAB14818.1 .
PIRi D69985.
RefSeqi NP_390736.1. NC_000964.3.
WP_003229541.1. NZ_CM000487.1.

3D structure databases

ProteinModelPortali P94545.
SMRi P94545. Positions 407-457, 708-785.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU28580.

Proteomic databases

PaxDbi P94545.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14818 ; CAB14818 ; BSU28580 .
GeneIDi 937447.
KEGGi bsu:BSU28580.
PATRICi 18977604. VBIBacSub10457_2990.

Organism-specific databases

GenoListi BSU28580. [Micado ]

Phylogenomic databases

eggNOGi COG1193.
HOGENOMi HOG000135096.
KOi K07456.
OMAi FGGIVHD.
OrthoDBi EOG6P5ZC4.
PhylomeDBi P94545.

Enzyme and pathway databases

BioCyci BSUB:BSU28580-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00092. MutS2.
InterProi IPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view ]
PANTHERi PTHR11361:SF14. PTHR11361:SF14. 1 hit.
Pfami PF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view ]
PIRSFi PIRSF005814. MutS_YshD. 1 hit.
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SM00463. SMR. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01069. mutS2. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism."
    Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J., Emmerson P.T., Harwood C.R.
    Microbiology 142:3067-3078(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiMUTS2_BACSU
AccessioniPrimary (citable) accession number: P94545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi