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P94545 (MUTS2_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endonuclease MutS2

EC=3.1.-.-
Gene names
Name:mutSB
Synonyms:mutS2, yshD
Ordered Locus Names:BSU28580
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity By similarity. HAMAP-Rule MF_00092

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00092

Sequence similarities

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.

Contains 1 Smr domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 785785Endonuclease MutS2 HAMAP-Rule MF_00092
PRO_0000115217

Regions

Domain710 – 78576Smr
Nucleotide binding335 – 3428ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P94545 [UniParc].

Last modified July 1, 1997. Version 2.
Checksum: 20D14CDB931167C2

FASTA78587,417
        10         20         30         40         50         60 
MQQKVLSALE FHKVKEQVIG HAASSLGKEM LLELKPSASI DEIKKQLDEV DEASDIIRLR 

        70         80         90        100        110        120 
GQAPFGGLVD IRGALRRAEI GSVLSPSEFT EISGLLYAVK QMKHFITQMA EDGVDIPLIH 

       130        140        150        160        170        180 
QHAEQLITLS DLERDINSCI DDHGEVLDHA SETLRGIRTQ LRTLESRVRD RLESMLRSSS 

       190        200        210        220        230        240 
ASKMLSDTIV TIRNDRFVIP VKQEYRSSYG GIVHDTSSSG ATLFIEPQAI VDMNNSLQQA 

       250        260        270        280        290        300 
KVKEKQEIER ILRVLTEKTA EYTEELFLDL QVLQTLDFIF AKARYAKAVK ATKPIMNDTG 

       310        320        330        340        350        360 
FIRLKKARHP LLPPDQVVAN DIELGRDFST IVITGPNTGG KTVTLKTLGL LTLMAQSGLH 

       370        380        390        400        410        420 
IPADEGSEAA VFEHVFADIG DEQSIEQSLS TFSSHMVNIV GILEQVNENS LVLFDELGAG 

       430        440        450        460        470        480 
TDPQEGAALA MSILDDVHRT NARVLATTHY PELKAYGYNR EGVMNASVEF DIETLSPTYK 

       490        500        510        520        530        540 
LLIGVPGRSN AFEISKRLGL PDHIIGQAKS EMTAEHNEVD TMIASLEQSK KRAEEELSET 

       550        560        570        580        590        600 
ESIRKEAEKL HKELQQQIIE LNSKKDKMLE EAEQQAAEKV KAAMKEAEDI IHELRTIKEE 

       610        620        630        640        650        660 
HKSFKDHELI NAKKRLEGAM PAFEKSKKPE KPKTQKRDFK PGDEVKVLTF GQKGTLLEKT 

       670        680        690        700        710        720 
GGNEWNVQIG ILKMKVKEKD LEFIKSAPEP KKEKMITAVK GKDYHVSLEL DLRGERYENA 

       730        740        750        760        770        780 
LSRVEKYLDD AVLAGYPRVS IIHGKGTGAL RKGVQDLLKN HRSVKSSRFG EAGEGGSGVT 


VVELK 

« Hide

References

« Hide 'large scale' references
[1]"The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism."
Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J., Emmerson P.T., Harwood C.R.
Microbiology 142:3067-3078(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z75208 Genomic DNA. Translation: CAA99569.1.
AL009126 Genomic DNA. Translation: CAB14818.1.
PIRD69985.
RefSeqNP_390736.1. NC_000964.3.

3D structure databases

ProteinModelPortalP94545.
SMRP94545. Positions 407-457, 708-785.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU28580.

Proteomic databases

PaxDbP94545.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14818; CAB14818; BSU28580.
GeneID937447.
KEGGbsu:BSU28580.
PATRIC18977604. VBIBacSub10457_2990.

Organism-specific databases

GenoListBSU28580. [Micado]

Phylogenomic databases

eggNOGCOG1193.
HOGENOMHOG000135096.
KOK07456.
OMAHDQSSTG.
OrthoDBEOG6P5ZC4.
ProtClustDBPRK00409.

Enzyme and pathway databases

BioCycBSUB:BSU28580-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00092. MutS2.
InterProIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFPIRSF005814. MutS_YshD. 1 hit.
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SM00463. SMR. 1 hit.
[Graphical view]
SUPFAMSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01069. mutS2. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS2_BACSU
AccessionPrimary (citable) accession number: P94545
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList