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Protein

HTH-type transcriptional regulator GltR

Gene

gltR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processAmino-acid biosynthesis, Glutamate biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciBSUB:BSU26670-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GltR
Gene namesi
Name:gltR
Synonyms:yrdL
Ordered Locus Names:BSU26670
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

No effect observed.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi219L → P: Gain-of-function mutation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056301 – 296HTH-type transcriptional regulator GltRAdd BLAST296

Proteomic databases

PaxDbiP94501
PRIDEiP94501

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014586

Structurei

3D structure databases

ProteinModelPortaliP94501
SMRiP94501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiCOG0583 LUCA
HOGENOMiHOG000233521
InParanoidiP94501
OMAiVLHYELN
PhylomeDBiP94501

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P94501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIQLLQVFL TTAREGSISK AALTLNYAQS NVTNKIQQLE NDLQTKLFYR
60 70 80 90 100
HSRGITLTPP GQILVSYSEK ILHTIEEARA AMGESSAPSG PLRIGSMETT
110 120 130 140 150
AAVWLPQLLA HYNNLYPNVD LNLVTGPTEQ QIQAVLHYEL NGAFISGPIE
160 170 180 190 200
HPDLVQEKVL DEEMVLVTSA SHPVISSIQD VQTQTMLVFR KGCSYRAKLN
210 220 230 240 250
HILQEEGLLP IKLMEFGILE AIIGCVSAGL GISLLPRSII ASHEKEGRIR
260 270 280 290
SHTISDKYSF VSTMFIRRKD TLITPALSAF LTHMRDHFQI KRPDQS
Length:296
Mass (Da):32,956
Last modified:July 7, 2009 - v3
Checksum:iD92417A604E5B48C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187L → V in AAB80905 (PubMed:9308178).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79494 Genomic DNA Translation: AAB47963.1
U93876 Genomic DNA Translation: AAB80905.1
AL009126 Genomic DNA Translation: CAB14608.2
PIRiC69635
RefSeqiNP_390544.2, NC_000964.3
WP_003246132.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14608; CAB14608; BSU26670
GeneIDi938189
KEGGibsu:BSU26670
PATRICifig|224308.179.peg.2898

Similar proteinsi

Entry informationi

Entry nameiGLTR_BACSU
AccessioniPrimary (citable) accession number: P94501
Secondary accession number(s): O07083
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 7, 2009
Last modified: January 31, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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