P94458 (P94458_BACLI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Beta-lactamase EMBL CAA71115.1
EC=3.5.2.6 EMBL CAA71115.1

Gene names

Name:

bla EMBL CAA71115.1

Organism

Bacillus licheniformis EMBL CAA71115.1

Taxonomic identifier

1402 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group

Protein attributes

Sequence length	265 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid. SAAS SAAS000871

Ontologies

Keywords
Biological process	Antibiotic resistance SAAS SAAS000871
Molecular function	Hydrolase SAAS SAAS000871 EMBL CAA71115.1
Technical term	3D-structure PDB 2X71 PDB 4A5R
Gene Ontology (GO)
Biological_process	beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAA71115.1
	Non-terminal residue	265	1	EMBL CAA71115.1

Sequences

	Sequence		Length	Mass (Da)
	P94458 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: BEA3E9418DCDA345	FASTA	265	29,474
	10 20 30 40 50 60 KTEMKDDFAK LEEQFDAKLG IFALDTGTNR TVTYRPDERF AFASTIKALT VGVLLQQKSI 70 80 90 100 110 120 EDLNQRITYT RDDLVNYNPI TEKHVDTGMT LKELADASLR YSDNTAQNLI LKQIGGPESL 130 140 150 160 170 180 KKELRKIGDE VTNPERFEPE LNEVNPGETQ DTSTARALAT SLQAFALEDK LPSEKRELLI 190 200 210 220 230 240 DWMKRNTTGD ALIRAGVPEG WEVADKTGAG SYGTRNDIAI IWPPKGDPVV LAVLSSRDKK 250 260 DAKYDDKLIA EATKVVVKAL NMNGK

References

[1]	Duez C.M.J. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BS3 EMBL CAA71115.1.
[2]	"Unexpected influence of a C-terminal-fused His-tag on the processing of an enzyme and on the kinetic and folding parameters." Ledent P., Duez C., Vanhove M., Lejeune A., Fonze E., Charlier P., Rhazi-Filali F., Thamm I., Guillaume G., Samyn B., Devreese B., Van Beeumen J., Lamotte-Brasseur J., Frere J.M. FEBS Lett. 413:194-196(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BS3 EMBL CAA71115.1.
[3]	"Structural basis for the interaction of lactivicins with serine beta-lactamases." Brown T., Charlier P., Herman R., Schofield C.J., Sauvage E. J. Med. Chem. 53:5890-5894(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
[4]	"Crystal Structure of Class a Beta-Lactamase from Bacillus Licheniformis Inhibited by Tazobactam." Power P., Herman R., Kerff F., Mercuri P., Galleni M., Gutkind G., Charlier P., Sauvage E. Submitted (OCT-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Y10006 Genomic DNA. Translation: CAA71115.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2X71	X-ray	2.10	A/B	1-265	[»]
4A5R	X-ray	2.10	A/B	1-265	[»]

ProteinModelPortal

P94458.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.40.710.10. 1 hit.

InterPro

IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]

PRINTS

PR00118. BLACTAMASEA.

SUPFAM

SSF56601. PBP_transp_fold. 1 hit.

PROSITE

PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P94458.

Entry information

Entry name

P94458_BACLI

Accession

Primary (citable) accession number: P94458

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)