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P94458

- P94458_BACLI

UniProt

P94458 - P94458_BACLI

Protein

Beta-lactamase

Gene

bla

Organism
Bacillus licheniformis
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei135 – 1351CitrateImported

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Antibiotic resistanceUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
    Gene namesi
    Name:blaImported
    OrganismiBacillus licheniformisImported
    Taxonomic identifieri1402 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2X71X-ray2.10A/B1-265[»]
    4A5RX-ray2.10A/B1-265[»]
    ProteinModelPortaliP94458.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP94458.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni149 – 1502Citrate bindingImported

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P94458-1 [UniParc]FASTAAdd to Basket

    « Hide

    KTEMKDDFAK LEEQFDAKLG IFALDTGTNR TVTYRPDERF AFASTIKALT    50
    VGVLLQQKSI EDLNQRITYT RDDLVNYNPI TEKHVDTGMT LKELADASLR 100
    YSDNTAQNLI LKQIGGPESL KKELRKIGDE VTNPERFEPE LNEVNPGETQ 150
    DTSTARALAT SLQAFALEDK LPSEKRELLI DWMKRNTTGD ALIRAGVPEG 200
    WEVADKTGAG SYGTRNDIAI IWPPKGDPVV LAVLSSRDKK DAKYDDKLIA 250
    EATKVVVKAL NMNGK 265
    Length:265
    Mass (Da):29,474
    Last modified:May 1, 1997 - v1
    Checksum:iBEA3E9418DCDA345
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei265 – 2651Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10006 Genomic DNA. Translation: CAA71115.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10006 Genomic DNA. Translation: CAA71115.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2X71 X-ray 2.10 A/B 1-265 [» ]
    4A5R X-ray 2.10 A/B 1-265 [» ]
    ProteinModelPortali P94458.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P94458.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Duez C.M.J.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BS3Imported.
    2. "Unexpected influence of a C-terminal-fused His-tag on the processing of an enzyme and on the kinetic and folding parameters."
      Ledent P., Duez C., Vanhove M., Lejeune A., Fonze E., Charlier P., Rhazi-Filali F., Thamm I., Guillaume G., Samyn B., Devreese B., Van Beeumen J., Lamotte-Brasseur J., Frere J.M.
      FEBS Lett. 413:194-196(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BS3Imported.
    3. "Structural basis for the interaction of lactivicins with serine beta-lactamases."
      Brown T., Charlier P., Herman R., Schofield C.J., Sauvage E.
      J. Med. Chem. 53:5890-5894(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
    4. "Crystal Structure of Class a Beta-Lactamase from Bacillus Licheniformis Inhibited by Tazobactam."
      Power P., Herman R., Kerff F., Mercuri P., Galleni M., Gutkind G., Charlier P., Sauvage E.
      Submitted (OCT-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

    Entry informationi

    Entry nameiP94458_BACLI
    AccessioniPrimary (citable) accession number: P94458
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3