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P94458

- P94458_BACLI

UniProt

P94458 - P94458_BACLI

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Protein

Beta-lactamase

Gene

bla

Organism
Bacillus licheniformis
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351CitrateImported

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Antibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
Gene namesi
Name:blaImported
OrganismiBacillus licheniformisImported
Taxonomic identifieri1402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X71X-ray2.10A/B1-265[»]
4A5RX-ray2.10A/B1-265[»]
ProteinModelPortaliP94458.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP94458.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 1502Citrate bindingImported

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotation

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P94458-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
KTEMKDDFAK LEEQFDAKLG IFALDTGTNR TVTYRPDERF AFASTIKALT
60 70 80 90 100
VGVLLQQKSI EDLNQRITYT RDDLVNYNPI TEKHVDTGMT LKELADASLR
110 120 130 140 150
YSDNTAQNLI LKQIGGPESL KKELRKIGDE VTNPERFEPE LNEVNPGETQ
160 170 180 190 200
DTSTARALAT SLQAFALEDK LPSEKRELLI DWMKRNTTGD ALIRAGVPEG
210 220 230 240 250
WEVADKTGAG SYGTRNDIAI IWPPKGDPVV LAVLSSRDKK DAKYDDKLIA
260
EATKVVVKAL NMNGK
Length:265
Mass (Da):29,474
Last modified:May 1, 1997 - v1
Checksum:iBEA3E9418DCDA345
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei265 – 2651Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10006 Genomic DNA. Translation: CAA71115.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10006 Genomic DNA. Translation: CAA71115.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2X71 X-ray 2.10 A/B 1-265 [» ]
4A5R X-ray 2.10 A/B 1-265 [» ]
ProteinModelPortali P94458.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P94458.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Duez C.M.J.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BS3Imported.
  2. "Unexpected influence of a C-terminal-fused His-tag on the processing of an enzyme and on the kinetic and folding parameters."
    Ledent P., Duez C., Vanhove M., Lejeune A., Fonze E., Charlier P., Rhazi-Filali F., Thamm I., Guillaume G., Samyn B., Devreese B., Van Beeumen J., Lamotte-Brasseur J., Frere J.M.
    FEBS Lett. 413:194-196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BS3Imported.
  3. "Structural basis for the interaction of lactivicins with serine beta-lactamases."
    Brown T., Charlier P., Herman R., Schofield C.J., Sauvage E.
    J. Med. Chem. 53:5890-5894(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
  4. "Crystal Structure of Class a Beta-Lactamase from Bacillus Licheniformis Inhibited by Tazobactam."
    Power P., Herman R., Kerff F., Mercuri P., Galleni M., Gutkind G., Charlier P., Sauvage E.
    Submitted (OCT-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Entry informationi

Entry nameiP94458_BACLI
AccessioniPrimary (citable) accession number: P94458
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3