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Protein

Probable 4-aminobutyrate aminotransferase

Gene

gabT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBSUB:BSU03900-MONOMER
UniPathwayiUPA00733

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Glutamate:succinic semialdehyde transaminase
L-AIBAT
Gene namesi
Name:gabT
Synonyms:ycnG
Ordered Locus Names:BSU03900
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203831 – 436Probable 4-aminobutyrate aminotransferaseAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP94427
PRIDEiP94427

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002198

Structurei

3D structure databases

ProteinModelPortaliP94427
SMRiP94427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108JPW Bacteria
COG0160 LUCA
HOGENOMiHOG000020206
InParanoidiP94427
KOiK07250
OMAiRVGNYLT
PhylomeDBiP94427

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004632 4NH2But_aminotransferase_bac
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00700 GABAtrnsam, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

P94427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTTASITT AQWQQKRDQF VSKGVSNGNR SLAVKGEGAE LYDLDGRRFI
60 70 80 90 100
DFAGAIGTLN VGHSHPKVVE AVKRQAEELI HPGFNVMMYP TYIELAEKLC
110 120 130 140 150
GIAPGSHEKK AIFLNSGAEA VENAVKIARK YTKRQGVVSF TRGFHGRTNM
160 170 180 190 200
TMSMTSKVKP YKFGFGPFAP EVYQAPFPYY YQKPAGMSDE SYDDMVIQAF
210 220 230 240 250
NDFFIASVAP ETVACVVMEP VQGEGGFIIP SKRFVQHVAS FCKEHGIVFV
260 270 280 290 300
ADEIQTGFAR TGTYFAIEHF DVVPDLITVS KSLAAGLPLS GVIGRAEMLD
310 320 330 340 350
AAAPGELGGT YAGSPLGCAA ALAVLDIIEE EGLNERSEEI GKIIEDKAYE
360 370 380 390 400
WKQEFPFIGD IRRLGAMAAI EIVKDPDTRE PDKTKAAAIA AYANQNGLLL
410 420 430
LTAGINGNII RFLTPLVISD SLLNEGLSIL EAGLRA
Length:436
Mass (Da):47,249
Last modified:May 1, 1997 - v1
Checksum:iD0961F6D4189A8F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50453 Genomic DNA Translation: BAA09021.1
AL009126 Genomic DNA Translation: CAB12198.1
PIRiC69764
RefSeqiNP_388272.1, NC_000964.3
WP_003234459.1, NZ_JNCM01000031.1

Genome annotation databases

EnsemblBacteriaiCAB12198; CAB12198; BSU03900
GeneIDi938264
KEGGibsu:BSU03900
PATRICifig|224308.179.peg.413

Similar proteinsi

Entry informationi

Entry nameiGABT_BACSU
AccessioniPrimary (citable) accession number: P94427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: February 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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