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Protein

Probable 4-aminobutyrate aminotransferase

Gene

gabT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBSUB:BSU03900-MONOMER.
UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Glutamate:succinic semialdehyde transaminase
L-AIBAT
Gene namesi
Name:gabT
Synonyms:ycnG
Ordered Locus Names:BSU03900
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203831 – 436Probable 4-aminobutyrate aminotransferaseAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP94427.
PRIDEiP94427.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002198.

Structurei

3D structure databases

ProteinModelPortaliP94427.
SMRiP94427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108JPW. Bacteria.
COG0160. LUCA.
HOGENOMiHOG000020206.
InParanoidiP94427.
KOiK07250.
OMAiCKVFFAS.
PhylomeDBiP94427.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTTASITT AQWQQKRDQF VSKGVSNGNR SLAVKGEGAE LYDLDGRRFI
60 70 80 90 100
DFAGAIGTLN VGHSHPKVVE AVKRQAEELI HPGFNVMMYP TYIELAEKLC
110 120 130 140 150
GIAPGSHEKK AIFLNSGAEA VENAVKIARK YTKRQGVVSF TRGFHGRTNM
160 170 180 190 200
TMSMTSKVKP YKFGFGPFAP EVYQAPFPYY YQKPAGMSDE SYDDMVIQAF
210 220 230 240 250
NDFFIASVAP ETVACVVMEP VQGEGGFIIP SKRFVQHVAS FCKEHGIVFV
260 270 280 290 300
ADEIQTGFAR TGTYFAIEHF DVVPDLITVS KSLAAGLPLS GVIGRAEMLD
310 320 330 340 350
AAAPGELGGT YAGSPLGCAA ALAVLDIIEE EGLNERSEEI GKIIEDKAYE
360 370 380 390 400
WKQEFPFIGD IRRLGAMAAI EIVKDPDTRE PDKTKAAAIA AYANQNGLLL
410 420 430
LTAGINGNII RFLTPLVISD SLLNEGLSIL EAGLRA
Length:436
Mass (Da):47,249
Last modified:May 1, 1997 - v1
Checksum:iD0961F6D4189A8F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50453 Genomic DNA. Translation: BAA09021.1.
AL009126 Genomic DNA. Translation: CAB12198.1.
PIRiC69764.
RefSeqiNP_388272.1. NC_000964.3.
WP_003234459.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12198; CAB12198; BSU03900.
GeneIDi938264.
KEGGibsu:BSU03900.
PATRICi18972354. VBIBacSub10457_0405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50453 Genomic DNA. Translation: BAA09021.1.
AL009126 Genomic DNA. Translation: CAB12198.1.
PIRiC69764.
RefSeqiNP_388272.1. NC_000964.3.
WP_003234459.1. NZ_JNCM01000031.1.

3D structure databases

ProteinModelPortaliP94427.
SMRiP94427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002198.

Proteomic databases

PaxDbiP94427.
PRIDEiP94427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12198; CAB12198; BSU03900.
GeneIDi938264.
KEGGibsu:BSU03900.
PATRICi18972354. VBIBacSub10457_0405.

Phylogenomic databases

eggNOGiENOG4108JPW. Bacteria.
COG0160. LUCA.
HOGENOMiHOG000020206.
InParanoidiP94427.
KOiK07250.
OMAiCKVFFAS.
PhylomeDBiP94427.

Enzyme and pathway databases

UniPathwayiUPA00733.
BioCyciBSUB:BSU03900-MONOMER.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGABT_BACSU
AccessioniPrimary (citable) accession number: P94427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.