Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable 4-aminobutyrate aminotransferase

Gene

gabT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Cofactori

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBSUB:BSU03900-MONOMER.
UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22)
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Glutamate:succinic semialdehyde transaminase
L-AIBAT
Gene namesi
Name:gabT
Synonyms:ycnG
Ordered Locus Names:BSU03900
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203831 – 436Probable 4-aminobutyrate aminotransferaseAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP94427.
PRIDEiP94427.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002198.

Structurei

3D structure databases

ProteinModelPortaliP94427.
SMRiP94427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108JPW. Bacteria.
COG0160. LUCA.
HOGENOMiHOG000020206.
InParanoidiP94427.
KOiK07250.
OMAiRVGNYLT.
PhylomeDBiP94427.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiView protein in InterPro
IPR004632. 4NH2But_aminotransferase_bac.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P94427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTTASITT AQWQQKRDQF VSKGVSNGNR SLAVKGEGAE LYDLDGRRFI
60 70 80 90 100
DFAGAIGTLN VGHSHPKVVE AVKRQAEELI HPGFNVMMYP TYIELAEKLC
110 120 130 140 150
GIAPGSHEKK AIFLNSGAEA VENAVKIARK YTKRQGVVSF TRGFHGRTNM
160 170 180 190 200
TMSMTSKVKP YKFGFGPFAP EVYQAPFPYY YQKPAGMSDE SYDDMVIQAF
210 220 230 240 250
NDFFIASVAP ETVACVVMEP VQGEGGFIIP SKRFVQHVAS FCKEHGIVFV
260 270 280 290 300
ADEIQTGFAR TGTYFAIEHF DVVPDLITVS KSLAAGLPLS GVIGRAEMLD
310 320 330 340 350
AAAPGELGGT YAGSPLGCAA ALAVLDIIEE EGLNERSEEI GKIIEDKAYE
360 370 380 390 400
WKQEFPFIGD IRRLGAMAAI EIVKDPDTRE PDKTKAAAIA AYANQNGLLL
410 420 430
LTAGINGNII RFLTPLVISD SLLNEGLSIL EAGLRA
Length:436
Mass (Da):47,249
Last modified:May 1, 1997 - v1
Checksum:iD0961F6D4189A8F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50453 Genomic DNA. Translation: BAA09021.1.
AL009126 Genomic DNA. Translation: CAB12198.1.
PIRiC69764.
RefSeqiNP_388272.1. NC_000964.3.
WP_003234459.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12198; CAB12198; BSU03900.
GeneIDi938264.
KEGGibsu:BSU03900.
PATRICifig|224308.179.peg.413.

Similar proteinsi

Entry informationi

Entry nameiGABT_BACSU
AccessioniPrimary (citable) accession number: P94427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: October 25, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families