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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.1 Publication

Caution

Was originally thought to be a zinc uptake system.1 Publication

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.1 Publication

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (mtrA), GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei183May be catalytically importantBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciBSUB:BSU03340-MONOMER
UniPathwayiUPA00848; UER00151

Protein family/group databases

TCDBi9.B.10.1.1 the putative tripartite zn(2+) transporter (tzt) family

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase 1B
Gene namesi
Name:folE2
Synonyms:yciA
Ordered Locus Names:BSU03340
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477011 – 304GTP cyclohydrolase FolE2Add BLAST304

Proteomic databases

PRIDEiP94398

Expressioni

Inductioni

Repressed by zinc, via zur.1 Publication

Interactioni

Protein-protein interaction databases

IntActiP94398, 1 interactor
MINTiP94398

Structurei

3D structure databases

ProteinModelPortaliP94398
SMRiP94398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.Curated

Phylogenomic databases

HOGENOMiHOG000280679
InParanoidiP94398
KOiK09007
OMAiHNQRGRG
PhylomeDBiP94398

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

P94398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQHTLLPKK TERLQYFGSV SPIKGEKPVE KEKMKDLQNI RKDYFFDIQH
60 70 80 90 100
VGVANVSHPV TITSAMMPAE QTTAANFTMT CNLPRNQKGI NMSRLTELLQ
110 120 130 140 150
VYHQNGWILS FSSLQQFTKE LAENMDTSSA TVEVRFPWFF ERKSPKLEKA
160 170 180 190 200
GLMHADIFMS VTYRKDQPFK QRAGISAKVT TLCPCSKEIS EYSAHNQRGT
210 220 230 240 250
VSIWADIHPA ASLPSDVKAD LLHAAESNAS ARLHPVLKRP DEKAVTETAY
260 270 280 290 300
ENPRFVEDLA RLIAADLFEL EWVSAFEIEC RNEESIHLHD AYAKLCFSKE

VDKI
Length:304
Mass (Da):34,564
Last modified:June 16, 2009 - v2
Checksum:i90A28F90FE9BDAB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202 – 209SIWADIHP → KHLGRIFTR in BAA08968 (PubMed:8969502).Curated8
Sequence conflicti222L → P in BAA08968 (PubMed:8969502).Curated1
Sequence conflicti290 – 295DAYAKL → RCLCEV in BAA08968 (PubMed:8969502).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50453 Genomic DNA Translation: BAA08968.1
AL009126 Genomic DNA Translation: CAB12128.2
PIRiH69759
RefSeqiNP_388216.2, NC_000964.3
WP_003246378.1, NZ_JNCM01000030.1

Genome annotation databases

EnsemblBacteriaiCAB12128; CAB12128; BSU03340
GeneIDi938325
KEGGibsu:BSU03340
PATRICifig|224308.179.peg.348

Similar proteinsi

Entry informationi

Entry nameiGCH4_BACSU
AccessioniPrimary (citable) accession number: P94398
Secondary accession number(s): Q797Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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