Reviewed, UniProtKB/Swiss-Prot P94327 (TRPC_BRAJA)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	blr4810

Organism

Bradyrhizobium japonicum [Complete proteome] [HAMAP]

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_0000154215
Experimental info
	Sequence conflict	79	1	L → F in AAB39010. Ref.1
	Sequence conflict	146	1	A → T in AAB39010. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P94327-1 [UniParc]. Last modified February 28, 2003. Version 2. Checksum: 7662A92C23FF0613	FASTA	273	29,373
	10 20 30 40 50 60 MSDILTKIET YKREEIAAAK RAQPLSVVEA TAKAQGAPRG FLRAIKAKHT NGDFALIAEV 70 80 90 100 110 120 KKASPSKGLI RADFDPPQLA KAYEAGGAAC LSVLTDTPSF QGHLDFMVAA RAATSLPVLR 130 140 150 160 170 180 KDFMFDAYQV VEARAHGADC ILIIMAALDD ATAKDLEDTA IAFGMDVLIE IHDRAELDRA 190 200 210 220 230 240 LKLRSPMIGV NNRNLRTFET TLATSEALAP LIPGDRLMVG ESGIFTPADL ARLERVGMST 250 260 270 FLVGESLMRQ ADVTAATRTL LARETTARAT GTR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of a symbiotically essential Bradyrhizobium japonicum operon consisting of trpD, trpC and a moaC-like gene." Kuykendall L.D., Hunter W.J. Biochim. Biophys. Acta 1350:277-281(1997) [PubMed: 9061023] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110.
[2]	"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U79771 Genomic DNA. Translation: AAB39010.1. BA000040 Genomic DNA. Translation: BAC50075.1.
PIR	T46959.
RefSeq	NP_771450.1.
3D structure databases
HSSP	HSSP built from PDB template 1PII based on UniProtKB P00909.
ModBase	Search...
Genome annotation databases
GeneID	1052206.
GenomeReviews	Gene locus blr4810 in contig BA000040_GR.
KEGG	bja:blr4810.
NMPDR	fig|224911.1.peg.4810.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P94327.
OMA	LRSPMIG.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR4810-MON.
BRENDA	4.1.1.48. 280.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BRAJA

Accession

Primary (citable) accession number: P94327

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 28, 2003
Last modified:	November 3, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)