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P94325

- CISY_BRADU

UniProt

P94325 - CISY_BRADU

Protein

Citrate synthase

Gene

gltA

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (28 Feb 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei310 – 3101PROSITE-ProRule annotation
    Active sitei368 – 3681PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-4872-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:blr4839
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Citrate synthasePRO_0000169939Add
    BLAST

    Proteomic databases

    PRIDEiP94325.

    Interactioni

    Protein-protein interaction databases

    STRINGi224911.blr4839.

    Structurei

    3D structure databases

    ProteinModelPortaliP94325.
    SMRiP94325. Positions 9-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000021224.
    KOiK01647.
    OrthoDBiEOG6P8TP4.
    PhylomeDBiP94325.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P94325-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAKASNKTA TLTVGNKNYD LPIHSGSVGP DVIDIGKLYG QSGLFTYDPG    50
    FTSTASCQSK ITYIDGDAGV LEYRGYPIEQ LAENGDFLET CYLLLYGNLP 100
    TAAQKKDFDD RVIHHTMVHE QMARFFQGFR RDAHPMAVMV ASVGALAAFY 150
    HDSTDINDPK QRMIASMRMI AKIPTLAAMA YKYTIGQPFV YPKNSLKFAE 200
    NFLHMCFAVP CEEYKINPVL ADALDKIFIL HADHEQNAST STVRIAGSSG 250
    ANPFACIAAG IACLWGPAHG GANEAALAML AEIGSVDKIP EFIAKVKDKN 300
    SEVRLMGFGH RVYKNYDPRA KIMQKMCHAV LKETGHGDDP MLKVAMELEK 350
    IALSDQYFID RKLYPNVDFY SGITLKAMGF PVSMFTVLFA VARTVGWISQ 400
    WSEMIEDPQQ KIGRPRQLYT GVTRRDYVAI KDRK 434
    Length:434
    Mass (Da):48,193
    Last modified:February 28, 2003 - v2
    Checksum:iDEB33EC2B4BACDB4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti210 – 2101P → S in AAB39736. 1 PublicationCurated
    Sequence conflicti281 – 2811A → G in AAB39736. 1 PublicationCurated
    Sequence conflicti346 – 3461M → L in AAB39736. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76375 Genomic DNA. Translation: AAB39736.1.
    BA000040 Genomic DNA. Translation: BAC50104.1.
    RefSeqiNP_771479.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC50104; BAC50104; BAC50104.
    GeneIDi1052140.
    KEGGibja:blr4839.
    PATRICi21193340. VBIBraJap65052_4919.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76375 Genomic DNA. Translation: AAB39736.1 .
    BA000040 Genomic DNA. Translation: BAC50104.1 .
    RefSeqi NP_771479.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali P94325.
    SMRi P94325. Positions 9-433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.blr4839.

    Proteomic databases

    PRIDEi P94325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC50104 ; BAC50104 ; BAC50104 .
    GeneIDi 1052140.
    KEGGi bja:blr4839.
    PATRICi 21193340. VBIBraJap65052_4919.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000021224.
    KOi K01647.
    OrthoDBi EOG6P8TP4.
    PhylomeDBi P94325.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci BJAP224911:GJEJ-4872-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the Bradyrhizobium japonicum gltA gene encoding a central enzyme of the TCA cycle."
      Levier K., Guerinot M.L.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 61A152.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiCISY_BRADU
    AccessioniPrimary (citable) accession number: P94325
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 28, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3