Reviewed,
UniProtKB/Swiss-Prot P94316 (DHE2_BACFR)
Last modified
November 25, 2008.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: NAD-specific glutamate dehydrogenase Short name=NAD-GDH EC=1.4.1.2 Alternative name(s): NADH-dependent glutamate dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Bacteroides fragilis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 817 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH. |
| Subunit structure | Homohexamer By similarity. |
| Induction | By high peptide concentrations. |
| Sequence similarities | Belongs to the Glu/Leu/Phe/Val dehydrogenases family. |
Ontologies
Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | amino acid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro glutamate dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 445 | 445 | NAD-specific glutamate dehydrogenase | PRO_0000182765 | |||||
Regions | |||||||||
| Nucleotide binding | 235 – 241 | 7 | NAD Potential | ||||||
Sites | |||||||||
| Active site | 124 | 1 | By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 44 | 1 | S → A in AAC26399. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The NADH-dependent glutamate dehydrogenase enzyme of Bacteroides fragilis Bf1 is induced by peptides in the growth medium." Abrahams G.L., Abratt V.R. Microbiology 144:1659-1667(1998) [PubMed: 9639936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BF1. |
| [2] | "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46. |
Cross-references
Sequence databases | |
|---|---|
| U78108 Genomic DNA. Translation: AAC26399.1. AP006841 Genomic DNA. Translation: BAD50378.1. | |
| RefSeq | YP_100912.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AUP based on UniProtKB P24295. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3084717. |
| GenomeReviews | Gene locus BF3635 in contig AP006841_GR. |
| KEGG | bfr:BF3635. |
| NMPDR | fig|295405.3.peg.3689. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P94316. |
Enzyme and pathway databases | |
| BioCyc | BFRA295405:BF3635-MON. |
Family and domain databases | |
| InterPro | IPR006095. Glu/Leu/Phe/Val_DHase. IPR006096. Glu/Leu/Phe/Val_DHase_C. IPR006097. Glu/Leu/Phe/Val_DHase_dimer. IPR014362. Glu_DHase. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR11606:SF2. GLFV_DH. 1 hit. |
| Pfam | PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000185. Glu_DH. 1 hit. |
| PRINTS | PR00082. GLFDHDRGNASE. |
| PROSITE | PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHE2_BACFR | ||||||||
| Accession | Primary (citable) accession number: P94316 Secondary accession number(s): Q64Q53 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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