Reviewed, UniProtKB/Swiss-Prot P94170 (CAH_ANASP)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase
    EC=4.2.1.1
Alternative name(s):
    Carbonate dehydratase

Gene names

Name:	ecaA
Ordered Locus Names:	all2929

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Post-translational modification	Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Tat-type signal Potential
	Chain	34 – 264	231	Carbonic anhydrase		PRO_0000004263
Sites
	Metal binding	127	1	Zinc; catalytic By similarity
	Metal binding	129	1	Zinc; catalytic By similarity
	Metal binding	146	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P94170-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 81C10CCD974B4172	FASTA	264	29,639
	10 20 30 40 50 60 MSSTLYRRQL LKLLGMSVLG TSFSSCVTSP ARAKTVNWGY IGKVGPEHWG ELSPDFALCQ 70 80 90 100 110 120 IGRKQTPIDL QIADVKDVHS SSQDLLVTNY QPTALHLINN GKTVQVNYQP GSYLKYAHQK 130 140 150 160 170 180 FELLQFHFHH FSEHRVDGKL YDMELHLVHR SKSGDLAVMG IFLQAGAFNP TLQIIWDATP 190 200 210 220 230 240 QNQGTDKRIE DINIDASQFL PAQHRFFTYS GSLTTPPCSE NVLWCVMATP IEASPAQIAK 250 260 FSQMFPQNAR PVQPLNDRLV IEAI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a gene encoding a vertebrate-type carbonic anhydrase in cyanobacteria." Soltes-Rak E., Mulligan M.E., Coleman J.R. J. Bacteriol. 179:769-774(1997) [PubMed: 9006032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U72708 Genomic DNA. Translation: AAC44831.1. BA000019 Genomic DNA. Translation: BAB74628.1.
PIR	AB2172.
RefSeq	NP_486969.1.
3D structure databases
SMR	P94170. Positions 37-262.
ModBase	Search...
Protein-protein interaction databases
STRING	P94170.
Genome annotation databases
GeneID	1106527.
GenomeReviews	Gene locus all2929 in contig BA000019_GR.
KEGG	ana:all2929.
NMPDR	fig|103690.1.peg.3236.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3338.
HOGENOM	HBG717384.
OMA	QFHFHAP.
Enzyme and pathway databases
BioCyc	NSP103690:ALL2929-MONOMER.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018340. Carbonic_anhydrase_CAH1-like. IPR006311. TAT_signal. IPR017909. Twin_arg_translocation_Tat. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF2. Carbonic_anhydrase_CAH1-like. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01409. TAT_signal_seq. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH_ANASP

Accession

Primary (citable) accession number: P94170

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1997
Last modified:	February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)