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Protein

60 kDa chaperonin

Gene

groL

Organism
Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
OrganismiActinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
Taxonomic identifieri715 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000632542 – 54760 kDa chaperoninAdd BLAST546

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP94166.
SMRiP94166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKDVKFGN DARVKMLKGV NVLADAVKVT LGPKGRNVVL DKAYGAPTIT
60 70 80 90 100
KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQAIV
110 120 130 140 150
NEGLKAVAAG MNPMDLKRGI DKAVVAVVEE LKAISKPCET SKEIEQVGTI
160 170 180 190 200
SANSDETVGK LIAQAMEKVG KEGVITVEDG TGLDDALDVV EGMQFDRGYL
210 220 230 240 250
SPYFINKPEA GTVELENPYI ILVDKKISNI REILPVLEAV AKAGKPLLIV
260 270 280 290 300
AEDIEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIAILTAGTV
310 320 330 340 350
ISEEIGMELE KATLEELGQA KRVVITKDNT TIIDGIGDEA QIKARVAQIR
360 370 380 390 400
QQIEDSTSDY DKEKLQERVA KLAGGVAVIK VGAATEVAMK EKKDRVDDAL
410 420 430 440 450
HATRAAVEEG IVPGGGVALV RAASKVATTL TGDNEEQNVG IKLALRAMEA
460 470 480 490 500
PLRQIVTNAG EEASVVARNV KDGNGNYGYN AGTEQYGDML EMGILDPPKV
510 520 530 540
TRSALQFAAS IAGLMITTEC MITDLPKEEK LDPAAAMGGM GGMGGMM
Length:547
Mass (Da):57,644
Last modified:January 23, 2007 - v3
Checksum:iE84BA6A15EA100A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55016 Genomic DNA. Translation: AAB51437.1.

Similar proteinsi

Entry informationi

Entry nameiCH60_ACTPL
AccessioniPrimary (citable) accession number: P94166
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 84 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families