ID   P94128_AERCA            Unreviewed;       493 AA.
AC   P94128;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1997, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   SubName: Full=Hemolysin {ECO:0000313|EMBL:AAC44637.1};
OS   Aeromonas caviae (Aeromonas punctata).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=648 {ECO:0000313|EMBL:AAC44637.1};
RN   [1] {ECO:0000313|EMBL:AAC44637.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8940472;
RA   Wang G., Tyler K.D., Munro C.K., Johnson W.M.;
RT   "Characterization of cytotoxic, hemolytic Aeromonas caviae clinical
RT   isolates and their identification by determining presence of a unique
RT   hemolysin gene.";
RL   J. Clin. Microbiol. 34:3203-3205(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Host cell membrane {ECO:0000256|ARBA:ARBA00004165}.
CC   -!- SIMILARITY: Belongs to the aerolysin family.
CC       {ECO:0000256|ARBA:ARBA00009831}.
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DR   EMBL; U40711; AAC44637.1; -; Genomic_DNA.
DR   AlphaFoldDB; P94128; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd20218; PFM_aerolysin; 1.
DR   Gene3D; 3.10.40.10; Aerolysin/Pertussis toxin (APT), N-terminal domain; 1.
DR   Gene3D; 3.30.412.10; Proaerolysin, chain A, domain 2; 1.
DR   Gene3D; 2.170.15.10; Proaerolysin, chain A, domain 3; 1.
DR   InterPro; IPR005830; Aerolysn.
DR   InterPro; IPR005138; APT_dom.
DR   InterPro; IPR037015; APT_N_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF01117; Aerolysin; 1.
DR   Pfam; PF03440; APT; 1.
DR   PRINTS; PR00754; AEROLYSIN.
DR   SMART; SM00999; Aerolysin; 1.
DR   SUPFAM; SSF56973; Aerolisin/ETX pore-forming domain; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Membrane {ECO:0000256|ARBA:ARBA00022870}; Signal {ECO:0000256|SAM:SignalP};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..493
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004162008"
FT   DOMAIN          24..105
FT                   /note="Aerolysin/Pertussis toxin"
FT                   /evidence="ECO:0000259|Pfam:PF03440"
SQ   SEQUENCE   493 AA;  54453 MW;  B8A9104107C8A633 CRC64;
     MDKLKITGLA LTISTLLMSQ AHGAEPIYPD QLRLFSLGKE VCGANYRPIN REEAQSVRNN
     IVGMMGQWQI SGLANNWVIM GSGYNGEIKP GSASDTWCYP TKPVTSEIPV LPALNIPDGD
     EKDVQWRLVH DSANFIKPAS YLAHYLGYAW VGGNHSPYVG EDMDVTQDGD SWLIRGNNDG
     GCDGYRCGEK SSILVSNFAY TLDPESFSHG EVTQSDRTLV KTVVGWVIND SDTPQSGYDV
     TLRYDTATNW SKTSTYGLSE KVSTKNKFKW PLVGETELSI EIAASQSWAQ QDGGSTTASL
     SQSARPTVPA HSKIPVKIEL YKANISYPYE FKADVSYDLT LNGFLRWGGN AWYTHPDNRP
     TKSHSFVIGP FKDKASSIRY QWDKRYIPGE VKWWDWNWTI QQNGADTMKN ALARVLRPVR
     ASITGDFHAE SQFAGNIEIG AAVPIGGDSK VRRARSVDGQ TGGLRLEMPL DASELSALGF
     DNVQIKLEPA TDQ
//