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P94126

- GLNA_AZOC5

UniProt

P94126 - GLNA_AZOC5

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Protein

Glutamine synthetase

Gene

glnA

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Nitrogen fixation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACAU438753:GJF3-1620-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:AZC_1601
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
ProteomesiUP000000270: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Glutamine synthetasePRO_0000153230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei398 – 3981O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi438753.AZC_1601.

Structurei

3D structure databases

ProteinModelPortaliP94126.
SMRiP94126. Positions 3-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
KOiK01915.
OMAiQKYKYVI.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P94126-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTAKEVLDF IKSNDVKYVD LRFTDPRGKW QHVTFDITMV DEDFFAEGQA
60 70 80 90 100
FDGSSIAGWK AINESDMLLM PDVTTACVDP FFSETTLSVV CDVLEPTTGE
110 120 130 140 150
PYGRDPRGIA KKAMAYLQST GIGDTVFFGP EAEFFIFDDV KFKADPYNTG
160 170 180 190 200
FKLDSIELPT NGDTDYEGGN LGHRIKTKGG YFPVPPLDSA QDMRSEMLAS
210 220 230 240 250
MAKMGAKVEK HHHEVASAQH ELGLKFGQLV TMADHLQVYK YCIHQVANIY
260 270 280 290 300
GKTATFMPKP VYGDNGSGMH VHQSIWKDGK PLFAGDKYAD LSQECLWYIG
310 320 330 340 350
GVIKHAKSLN AFTNPLTNSY KRLVPGYEAP VLLAYSARNR SASCRIPYTN
360 370 380 390 400
NPKAKRVEVR FPDPGANPYL AFSALFMAGM DGILNKIDPG SAMDKDLYDL
410 420 430 440 450
PPAELKQIPT VCGSLREALE SLAKDHDYLL KGDVFQKDFI ESYIDLKMQE
460
VARFEMTPHP VEFEMYYSV
Length:469
Mass (Da):52,386
Last modified:February 26, 2008 - v2
Checksum:i302A2DA5C9DB35CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 603GWK → AE in CAA71265. (PubMed:9171403)Curated
Sequence conflicti279 – 2791G → R in CAA71265. (PubMed:9171403)Curated
Sequence conflicti413 – 4131G → C in CAA71265. (PubMed:9171403)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10213 Genomic DNA. Translation: CAA71265.1.
AP009384 Genomic DNA. Translation: BAF87599.1.
RefSeqiWP_012170129.1. NC_009937.1.
YP_001524517.1. NC_009937.1.

Genome annotation databases

EnsemblBacteriaiBAF87599; BAF87599; AZC_1601.
GeneIDi5691233.
KEGGiazc:AZC_1601.
PATRICi21019821. VBIAzoCau17976_1676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10213 Genomic DNA. Translation: CAA71265.1 .
AP009384 Genomic DNA. Translation: BAF87599.1 .
RefSeqi WP_012170129.1. NC_009937.1.
YP_001524517.1. NC_009937.1.

3D structure databases

ProteinModelPortali P94126.
SMRi P94126. Positions 3-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 438753.AZC_1601.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF87599 ; BAF87599 ; AZC_1601 .
GeneIDi 5691233.
KEGGi azc:AZC_1601.
PATRICi 21019821. VBIAzoCau17976_1676.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005157.
KOi K01915.
OMAi QKYKYVI.
OrthoDBi EOG6B360N.

Enzyme and pathway databases

BioCyci ACAU438753:GJF3-1620-MONOMER.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Azorhizobium caulinodans glnB and glnA genes: involvement of the P(II) protein in symbiotic nitrogen fixation."
    Michel-Reydellet N., Desnoues N., Elmerich C., Kaminski P.A.
    J. Bacteriol. 179:3580-3587(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
    Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43989 / DSM 5975 / ORS 571.

Entry informationi

Entry nameiGLNA_AZOC5
AccessioniPrimary (citable) accession number: P94126
Secondary accession number(s): A8HYD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3