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P94111

- STS1_ARATH

UniProt

P94111 - STS1_ARATH

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Protein

Strictosidine synthase 1

Gene

SS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.By similarity

Catalytic activityi

3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

Pathwayi

GO - Molecular functioni

  1. lyase activity Source: UniProtKB-KW

GO - Biological processi

  1. alkaloid metabolic process Source: UniProtKB-KW
  2. biosynthetic process Source: InterPro
  3. response to jasmonic acid Source: TAIR
  4. response to wounding Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Alkaloid metabolism

Enzyme and pathway databases

BioCyciARA:AT1G74020-MONOMER.
UniPathwayiUPA00311; UER00447.

Names & Taxonomyi

Protein namesi
Recommended name:
Strictosidine synthase 1 (EC:4.3.3.2)
Short name:
SS-1
Gene namesi
Name:SS1
Ordered Locus Names:At1g74020
ORF Names:F2P9.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G74020.

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: TAIR
  2. plasma membrane Source: TAIR
  3. plasmodesma Source: TAIR
  4. vacuolar membrane Source: TAIR
  5. vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 335313Strictosidine synthase 1PRO_0000033330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP94111.
PRIDEiP94111.

Expressioni

Gene expression databases

GenevestigatoriP94111.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G74020.1-P.

Structurei

3D structure databases

ProteinModelPortaliP94111.
SMRiP94111. Positions 38-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3386.
HOGENOMiHOG000223915.
KOiK01757.
OMAiEVNEFEG.
PhylomeDBiP94111.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view]
PANTHERiPTHR10426:SF22. PTHR10426:SF22. 1 hit.
PfamiPF03088. Str_synth. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94111-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSFCSMISL LLLLSLSSAV FSDDASFQKL PVPETRSGPE AFAFDSTGKG
60 70 80 90 100
FYTGVSGGKI LKYLPETGYV DFAQITESSN SSWCDGTIGT ALAGRCGRPA
110 120 130 140 150
GIAFNEKTGD LYVADAPLGL HVISPAGGLA TKITDSVDGK PFKFLDGLDV
160 170 180 190 200
DPTTGVVYFT SFSSRFSPIQ VLIALGLKDA TGKLYKYDPS TKVVTVLMEG
210 220 230 240 250
LSGSAGCAVS SDGSFVLVSQ FTKSNIKRYW IKGPKAGSSE DFTNSVSNPD
260 270 280 290 300
NIKRIGSTGN FWVASVVNKI IVPTNPSAVK VNSNGEVLQT IPLKDKFGDT
310 320 330
LLSEVNEFEG NLYIGTLTGP FAGILKLEKG SCPAT
Length:335
Mass (Da):35,293
Last modified:June 6, 2002 - v2
Checksum:iC1382BF040A72849
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191A → P in AAB40594. 1 PublicationCurated
Sequence conflicti19 – 191A → P in AAB40593. 1 PublicationCurated
Sequence conflicti327 – 3271L → I in AAB40594. 1 PublicationCurated
Sequence conflicti327 – 3271L → I in AAB40593. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43945 mRNA. Translation: AAB40594.1.
U43713 Genomic DNA. Translation: AAB40593.1.
AC016662 Genomic DNA. Translation: AAG52513.1.
CP002684 Genomic DNA. Translation: AEE35538.1.
AY034970 mRNA. Translation: AAK59475.1.
AY062976 mRNA. Translation: AAL34150.1.
PIRiA96768.
RefSeqiNP_177542.1. NM_106061.3.
UniGeneiAt.24431.
At.74858.

Genome annotation databases

EnsemblPlantsiAT1G74020.1; AT1G74020.1; AT1G74020.
GeneIDi843740.
KEGGiath:AT1G74020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43945 mRNA. Translation: AAB40594.1 .
U43713 Genomic DNA. Translation: AAB40593.1 .
AC016662 Genomic DNA. Translation: AAG52513.1 .
CP002684 Genomic DNA. Translation: AEE35538.1 .
AY034970 mRNA. Translation: AAK59475.1 .
AY062976 mRNA. Translation: AAL34150.1 .
PIRi A96768.
RefSeqi NP_177542.1. NM_106061.3.
UniGenei At.24431.
At.74858.

3D structure databases

ProteinModelPortali P94111.
SMRi P94111. Positions 38-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G74020.1-P.

Proteomic databases

PaxDbi P94111.
PRIDEi P94111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G74020.1 ; AT1G74020.1 ; AT1G74020 .
GeneIDi 843740.
KEGGi ath:AT1G74020.

Organism-specific databases

TAIRi AT1G74020.

Phylogenomic databases

eggNOGi COG3386.
HOGENOMi HOG000223915.
KOi K01757.
OMAi EVNEFEG.
PhylomeDBi P94111.

Enzyme and pathway databases

UniPathwayi UPA00311 ; UER00447 .
BioCyci ARA:AT1G74020-MONOMER.

Gene expression databases

Genevestigatori P94111.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view ]
PANTHERi PTHR10426:SF22. PTHR10426:SF22. 1 hit.
Pfami PF03088. Str_synth. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Jain A.K., Nessler C.L.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Landsberg erecta.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiSTS1_ARATH
AccessioniPrimary (citable) accession number: P94111
Secondary accession number(s): Q9C9C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3