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Protein

Protein STRICTOSIDINE SYNTHASE-LIKE 12

Gene

SSL12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.By similarity

Catalytic activityi

3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

Pathwayi: 3alpha(S)-strictosidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 3alpha(S)-strictosidine from secologanin and tryptamine.
Proteins known to be involved in this subpathway in this organism are:
  1. Protein STRICTOSIDINE SYNTHASE-LIKE 11 (SSL11), Protein STRICTOSIDINE SYNTHASE-LIKE 12 (SSL12)
This subpathway is part of the pathway 3alpha(S)-strictosidine biosynthesis, which is itself part of Alkaloid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3alpha(S)-strictosidine from secologanin and tryptamine, the pathway 3alpha(S)-strictosidine biosynthesis and in Alkaloid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • alkaloid metabolic process Source: UniProtKB-KW
  • biosynthetic process Source: InterPro
  • cellular response to potassium ion starvation Source: UniProtKB
  • response to jasmonic acid Source: TAIR
  • response to wounding Source: TAIR

Keywordsi

Molecular functionLyase
Biological processAlkaloid metabolism

Enzyme and pathway databases

BioCyciARA:AT1G74020-MONOMER
UniPathwayiUPA00311; UER00447

Names & Taxonomyi

Protein namesi
Recommended name:
Protein STRICTOSIDINE SYNTHASE-LIKE 121 Publication (EC:4.3.3.2)
Short name:
AtSSL121 Publication
Alternative name(s):
Strictosidine synthase 1
Short name:
SS-1
Strictosidine synthase 131 Publication
Short name:
AtSS131 Publication
Gene namesi
Name:SSL121 Publication
Synonyms:SS1, SS131 Publication
Ordered Locus Names:At1g74020Imported
ORF Names:F2P9.11Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G74020
TAIRilocus:2031486 AT1G74020

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003333023 – 335Protein STRICTOSIDINE SYNTHASE-LIKE 12Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP94111
PRIDEiP94111

Expressioni

Inductioni

Upon potassium (K) starvation.1 Publication

Gene expression databases

ExpressionAtlasiP94111 baseline and differential
GenevisibleiP94111 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G74020.1

Structurei

3D structure databases

ProteinModelPortaliP94111
SMRiP94111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1520 Eukaryota
COG3386 LUCA
HOGENOMiHOG000223915
KOiK01757
OMAiRYTPIQV
OrthoDBiEOG09360F65
PhylomeDBiP94111

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR018119 Strictosidine_synth_cons-reg
IPR004141 Strictosidine_synthase
PANTHERiPTHR10426 PTHR10426, 1 hit
PfamiView protein in Pfam
PF03088 Str_synth, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P94111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFCSMISL LLLLSLSSAV FSDDASFQKL PVPETRSGPE AFAFDSTGKG
60 70 80 90 100
FYTGVSGGKI LKYLPETGYV DFAQITESSN SSWCDGTIGT ALAGRCGRPA
110 120 130 140 150
GIAFNEKTGD LYVADAPLGL HVISPAGGLA TKITDSVDGK PFKFLDGLDV
160 170 180 190 200
DPTTGVVYFT SFSSRFSPIQ VLIALGLKDA TGKLYKYDPS TKVVTVLMEG
210 220 230 240 250
LSGSAGCAVS SDGSFVLVSQ FTKSNIKRYW IKGPKAGSSE DFTNSVSNPD
260 270 280 290 300
NIKRIGSTGN FWVASVVNKI IVPTNPSAVK VNSNGEVLQT IPLKDKFGDT
310 320 330
LLSEVNEFEG NLYIGTLTGP FAGILKLEKG SCPAT
Length:335
Mass (Da):35,293
Last modified:June 6, 2002 - v2
Checksum:iC1382BF040A72849
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → P in AAB40594 (Ref. 1) Curated1
Sequence conflicti19A → P in AAB40593 (Ref. 1) Curated1
Sequence conflicti327L → I in AAB40594 (Ref. 1) Curated1
Sequence conflicti327L → I in AAB40593 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43945 mRNA Translation: AAB40594.1
U43713 Genomic DNA Translation: AAB40593.1
AC016662 Genomic DNA Translation: AAG52513.1
CP002684 Genomic DNA Translation: AEE35538.1
AY034970 mRNA Translation: AAK59475.1
AY062976 mRNA Translation: AAL34150.1
PIRiA96768
RefSeqiNP_177542.1, NM_106061.4
UniGeneiAt.24431
At.74858

Genome annotation databases

EnsemblPlantsiAT1G74020.1; AT1G74020.1; AT1G74020
GeneIDi843740
GrameneiAT1G74020.1; AT1G74020.1; AT1G74020
KEGGiath:AT1G74020

Similar proteinsi

Entry informationi

Entry nameiSSL12_ARATH
AccessioniPrimary (citable) accession number: P94111
Secondary accession number(s): Q9C9C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: April 25, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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