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P94111

- STS1_ARATH

UniProt

P94111 - STS1_ARATH

Protein

Strictosidine synthase 1

Gene

SS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.By similarity

    Catalytic activityi

    3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

    Pathwayi

    GO - Molecular functioni

    1. lyase activity Source: UniProtKB-KW

    GO - Biological processi

    1. alkaloid metabolic process Source: UniProtKB-KW
    2. biosynthetic process Source: InterPro
    3. response to jasmonic acid Source: TAIR
    4. response to wounding Source: TAIR

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Alkaloid metabolism

    Enzyme and pathway databases

    BioCyciARA:AT1G74020-MONOMER.
    UniPathwayiUPA00311; UER00447.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Strictosidine synthase 1 (EC:4.3.3.2)
    Short name:
    SS-1
    Gene namesi
    Name:SS1
    Ordered Locus Names:At1g74020
    ORF Names:F2P9.11
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G74020.

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: TAIR
    2. plasma membrane Source: TAIR
    3. plasmodesma Source: TAIR
    4. vacuolar membrane Source: TAIR
    5. vacuole Source: TAIR

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 335313Strictosidine synthase 1PRO_0000033330Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP94111.
    PRIDEiP94111.

    Expressioni

    Gene expression databases

    GenevestigatoriP94111.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G74020.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP94111.
    SMRiP94111. Positions 38-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the strictosidine synthase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3386.
    HOGENOMiHOG000223915.
    InParanoidiP94111.
    KOiK01757.
    OMAiEVNEFEG.
    PhylomeDBiP94111.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR018119. Strictosidine_synth_cons-reg.
    IPR004141. Strictosidine_synthase.
    [Graphical view]
    PANTHERiPTHR10426:SF22. PTHR10426:SF22. 1 hit.
    PfamiPF03088. Str_synth. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P94111-1 [UniParc]FASTAAdd to Basket

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    MTSFCSMISL LLLLSLSSAV FSDDASFQKL PVPETRSGPE AFAFDSTGKG    50
    FYTGVSGGKI LKYLPETGYV DFAQITESSN SSWCDGTIGT ALAGRCGRPA 100
    GIAFNEKTGD LYVADAPLGL HVISPAGGLA TKITDSVDGK PFKFLDGLDV 150
    DPTTGVVYFT SFSSRFSPIQ VLIALGLKDA TGKLYKYDPS TKVVTVLMEG 200
    LSGSAGCAVS SDGSFVLVSQ FTKSNIKRYW IKGPKAGSSE DFTNSVSNPD 250
    NIKRIGSTGN FWVASVVNKI IVPTNPSAVK VNSNGEVLQT IPLKDKFGDT 300
    LLSEVNEFEG NLYIGTLTGP FAGILKLEKG SCPAT 335
    Length:335
    Mass (Da):35,293
    Last modified:June 6, 2002 - v2
    Checksum:iC1382BF040A72849
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191A → P in AAB40594. 1 PublicationCurated
    Sequence conflicti19 – 191A → P in AAB40593. 1 PublicationCurated
    Sequence conflicti327 – 3271L → I in AAB40594. 1 PublicationCurated
    Sequence conflicti327 – 3271L → I in AAB40593. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43945 mRNA. Translation: AAB40594.1.
    U43713 Genomic DNA. Translation: AAB40593.1.
    AC016662 Genomic DNA. Translation: AAG52513.1.
    CP002684 Genomic DNA. Translation: AEE35538.1.
    AY034970 mRNA. Translation: AAK59475.1.
    AY062976 mRNA. Translation: AAL34150.1.
    PIRiA96768.
    RefSeqiNP_177542.1. NM_106061.3.
    UniGeneiAt.24431.
    At.74858.

    Genome annotation databases

    EnsemblPlantsiAT1G74020.1; AT1G74020.1; AT1G74020.
    GeneIDi843740.
    KEGGiath:AT1G74020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43945 mRNA. Translation: AAB40594.1 .
    U43713 Genomic DNA. Translation: AAB40593.1 .
    AC016662 Genomic DNA. Translation: AAG52513.1 .
    CP002684 Genomic DNA. Translation: AEE35538.1 .
    AY034970 mRNA. Translation: AAK59475.1 .
    AY062976 mRNA. Translation: AAL34150.1 .
    PIRi A96768.
    RefSeqi NP_177542.1. NM_106061.3.
    UniGenei At.24431.
    At.74858.

    3D structure databases

    ProteinModelPortali P94111.
    SMRi P94111. Positions 38-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G74020.1-P.

    Proteomic databases

    PaxDbi P94111.
    PRIDEi P94111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G74020.1 ; AT1G74020.1 ; AT1G74020 .
    GeneIDi 843740.
    KEGGi ath:AT1G74020.

    Organism-specific databases

    TAIRi AT1G74020.

    Phylogenomic databases

    eggNOGi COG3386.
    HOGENOMi HOG000223915.
    InParanoidi P94111.
    KOi K01757.
    OMAi EVNEFEG.
    PhylomeDBi P94111.

    Enzyme and pathway databases

    UniPathwayi UPA00311 ; UER00447 .
    BioCyci ARA:AT1G74020-MONOMER.

    Gene expression databases

    Genevestigatori P94111.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR018119. Strictosidine_synth_cons-reg.
    IPR004141. Strictosidine_synthase.
    [Graphical view ]
    PANTHERi PTHR10426:SF22. PTHR10426:SF22. 1 hit.
    Pfami PF03088. Str_synth. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jain A.K., Nessler C.L.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: cv. Landsberg erecta.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiSTS1_ARATH
    AccessioniPrimary (citable) accession number: P94111
    Secondary accession number(s): Q9C9C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3