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P94111 (STS1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Strictosidine synthase 1
Short name=SS-1
EC=4.3.3.2
Gene names
Name:SS1
Ordered Locus Names:At1g74020
ORF Names:F2P9.11
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis By similarity.

Catalytic activity

3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

Pathway

Alkaloid biosynthesis; 3alpha(S)-strictosidine biosynthesis; 3alpha(S)-strictosidine from secologanin and tryptamine: step 1/1.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the strictosidine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 335313Strictosidine synthase 1
PRO_0000033330

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict191A → P in AAB40594. Ref.1
Sequence conflict191A → P in AAB40593. Ref.1
Sequence conflict3271L → I in AAB40594. Ref.1
Sequence conflict3271L → I in AAB40593. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P94111 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: C1382BF040A72849

FASTA33535,293
        10         20         30         40         50         60 
MTSFCSMISL LLLLSLSSAV FSDDASFQKL PVPETRSGPE AFAFDSTGKG FYTGVSGGKI 

        70         80         90        100        110        120 
LKYLPETGYV DFAQITESSN SSWCDGTIGT ALAGRCGRPA GIAFNEKTGD LYVADAPLGL 

       130        140        150        160        170        180 
HVISPAGGLA TKITDSVDGK PFKFLDGLDV DPTTGVVYFT SFSSRFSPIQ VLIALGLKDA 

       190        200        210        220        230        240 
TGKLYKYDPS TKVVTVLMEG LSGSAGCAVS SDGSFVLVSQ FTKSNIKRYW IKGPKAGSSE 

       250        260        270        280        290        300 
DFTNSVSNPD NIKRIGSTGN FWVASVVNKI IVPTNPSAVK VNSNGEVLQT IPLKDKFGDT 

       310        320        330 
LLSEVNEFEG NLYIGTLTGP FAGILKLEKG SCPAT

« Hide

References

« Hide 'large scale' references
[1]Jain A.K., Nessler C.L.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: cv. Landsberg erecta.
[2]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U43945 mRNA. Translation: AAB40594.1.
U43713 Genomic DNA. Translation: AAB40593.1.
AC016662 Genomic DNA. Translation: AAG52513.1.
CP002684 Genomic DNA. Translation: AEE35538.1.
AY034970 mRNA. Translation: AAK59475.1.
AY062976 mRNA. Translation: AAL34150.1.
IPIIPI00544988.
PIRA96768.
RefSeqNP_177542.1. NM_106061.3.
UniGeneAt.24431.
At.74858.

3D structure databases

ProteinModelPortalP94111.
SMRP94111. Positions 38-325.
ModBaseSearch...

Protein-protein interaction databases

STRING3702.AT1G74020.1-P.

Proteomic databases

PaxDbP94111.
PRIDEP94111.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G74020.1; AT1G74020.1; AT1G74020.
GeneID843740.
KEGGath:AT1G74020.

Organism-specific databases

TAIRAt1g74020.

Phylogenomic databases

eggNOGCOG3386.
HOGENOMHOG000223915.
InParanoidP94111.
KOK01757.
OMAESSNSSW.
PhylomeDBP94111.
ProtClustDBCLSN2682194.

Enzyme and pathway databases

UniPathwayUPA00311; UER00447.

Gene expression databases

GenevestigatorP94111.
GermOnlineAT1G74020. Arabidopsis thaliana.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
[Graphical view]
PfamPF03088. Str_synth. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSTS1_ARATH
AccessionPrimary (citable) accession number: P94111
Secondary accession number(s): Q9C9C3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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