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Protein

Dehydration-responsive element-binding protein 1B

Gene

DREB1B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates cold-inducible transcription. CBF/DREB1 factors play a key role in freezing tolerance and cold acclimation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 104AP2/ERFPROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • cold acclimation Source: TAIR
  • positive regulation of transcription, DNA-templated Source: TAIR
  • response to cold Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydration-responsive element-binding protein 1B1 Publication
Short name:
Protein DREB1B1 Publication
Alternative name(s):
C-repeat/dehydration-responsive element-binding factor 11 Publication
Short name:
C-repeat-binding factor 11 Publication
Short name:
CRT/DRE-binding factor 11 Publication
Gene namesi
Name:DREB1B1 Publication
Synonyms:CBF11 Publication, ERF0291 Publication
Ordered Locus Names:At4g25490Imported
ORF Names:M7J2.140Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G25490
TAIRilocus:2131854 AT4G25490

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125291 – 213Dehydration-responsive element-binding protein 1BAdd BLAST213

Proteomic databases

PaxDbiP93835

Expressioni

Inductioni

By cold stress (PubMed:9735350). Subject to degradation by the 26S proteasome pathway in freezing conditions (PubMed:28344081).2 Publications

Gene expression databases

ExpressionAtlasiP93835 baseline and differential
GenevisibleiP93835 AT

Interactioni

Subunit structurei

Interacts with 14-3-3 proteins GRF1, GRF3, GRF5, GRF6, GRF7, GRF9 and GRF10 in the nucleus upon freezing.1 Publication

Protein-protein interaction databases

BioGridi13940, 3 interactors
IntActiP93835, 4 interactors
STRINGi3702.AT4G25490.1

Structurei

3D structure databases

ProteinModelPortaliP93835
SMRiP93835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 44Nuclear localization signalSequence analysisAdd BLAST13

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IVY9 Eukaryota
ENOG410YK37 LUCA
HOGENOMiHOG000237624
InParanoidiP93835
KOiK09286
OMAiDYCPTLA
OrthoDBiEOG09360N5C
PhylomeDBiP93835

Family and domain databases

CDDicd00018 AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847 AP2, 1 hit
PRINTSiPR00367 ETHRSPELEMNT
SMARTiView protein in SMART
SM00380 AP2, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032 AP2_ERF, 1 hit

Sequencei

Sequence statusi: Complete.

P93835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFSAFSEM FGSDYEPQGG DYCPTLATSC PKKPAGRKKF RETRHPIYRG
60 70 80 90 100
VRQRNSGKWV SEVREPNKKT RIWLGTFQTA EMAARAHDVA ALALRGRSAC
110 120 130 140 150
LNFADSAWRL RIPESTCAKD IQKAAAEAAL AFQDETCDTT TTNHGLDMEE
160 170 180 190 200
TMVEAIYTPE QSEGAFYMDE ETMFGMPTLL DNMAEGMLLP PPSVQWNHNY
210
DGEGDGDVSL WSY
Length:213
Mass (Da):23,830
Last modified:May 24, 2004 - v2
Checksum:iED1B79183C3D34C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143N → D in AAC49662 (PubMed:9023378).Curated1
Sequence conflicti143N → D in AAC99369 (PubMed:9881163).Curated1
Sequence conflicti143N → D in AAV80413 (PubMed:16244146).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti127E → K in strain: cv. Cvi-1. 1 Publication1
Natural varianti178T → S in strain: cv. Cvi-1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77378 mRNA Translation: AAC49662.1
AB007788 mRNA Translation: BAA33792.1
AB013816 Genomic DNA Translation: BAA33435.1
AF076155 Genomic DNA Translation: AAC99369.1
AY667247 Genomic DNA Translation: AAV80413.1
AL022197 Genomic DNA Translation: CAA18177.1
AL161563 Genomic DNA Translation: CAB81359.1
CP002687 Genomic DNA Translation: AEE85066.1
PIRiJE0298
RefSeqiNP_567721.1, NM_118681.4
UniGeneiAt.232

Genome annotation databases

EnsemblPlantsiAT4G25490.1; AT4G25490.1; AT4G25490
GeneIDi828653
GrameneiAT4G25490.1; AT4G25490.1; AT4G25490
KEGGiath:AT4G25490

Similar proteinsi

Entry informationi

Entry nameiDRE1B_ARATH
AccessioniPrimary (citable) accession number: P93835
Secondary accession number(s): O65611, Q5QE71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 25, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health