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Protein

Auxin-responsive protein IAA17

Gene

IAA17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.1 Publication

Miscellaneous

Increased auxin response of mutants axr3-1 and axr3-3 may result from an increased stability of AXR3.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • identical protein binding Source: IntAct

GO - Biological processi

  • auxin-activated signaling pathway Source: TAIR
  • positive regulation of leaf senescence Source: TAIR
  • response to auxin Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processAuxin signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin-responsive protein IAA17
Alternative name(s):
Auxin response 3
Indoleacetic acid-induced protein 17
Gene namesi
Name:IAA17
Synonyms:AXR3
Ordered Locus Names:At1g04250
ORF Names:F19P19.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G04250
TAIRilocus:2018374 AT1G04250

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16L → F: Suppresses the axr3-1 phenotype; when associated with L-88. 1 Publication1
Mutagenesisi88P → L in axr3-1; gain of function. Affects auxin-related developmental processes. Affects photomorphogenesis. 1
Mutagenesisi89V → G in axr3-3; gain of function. Affects auxin-related developmental processes. Affects photomorphogenesis. 1
Mutagenesisi114K → A: No effect on interaction with ARF7. 1 Publication1
Mutagenesisi118D → N: Suppresses the axr3-1 phenotype; when associated with L-88. 1 Publication1
Mutagenesisi121P → S: Suppresses the axr3-1 phenotype; when associated with L-88. 1 Publication1
Mutagenesisi183D → A: No effect on interaction with ARF7; when associated with A-187. Loss of interaction with ARF7; when associated with A-114 and A-187. 1 Publication1
Mutagenesisi187D → A: No effect on interaction with ARF7; when associated with A-183. Loss of interaction with ARF7; when associated with A-114 and A-183. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001128481 – 229Auxin-responsive protein IAA17Add BLAST229

Post-translational modificationi

Phosphorylated by phytochrome A in vitro.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP93830
PRIDEiP93830

Expressioni

Inductioni

By auxin.

Gene expression databases

ExpressionAtlasiP93830 differential
GenevisibleiP93830 AT

Interactioni

Subunit structurei

Homodimers and heterodimers (PubMed:18258861, PubMed:21734647). Interacts with the auxin response factors ARF1 and IAA24 (PubMed:21734647). Interacts with IAA1 (PubMed:9342315, PubMed:21734647). Interacts with TPL (PubMed:18258861, PubMed:21734647). Interacts (via PB1 domain) with ARF7 (via PB1 domain) (PubMed:21734647, PubMed:24706860).4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi24803, 39 interactors
ELMiP93830
IntActiP93830, 69 interactors
STRINGi3702.AT1G04250.1

Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi113 – 120Combined sources8
Beta strandi124 – 126Combined sources3
Helixi128 – 130Combined sources3
Helixi134 – 148Combined sources15
Beta strandi151 – 154Combined sources4
Turni156 – 162Combined sources7
Helixi163 – 173Combined sources11
Turni174 – 176Combined sources3
Beta strandi180 – 182Combined sources3
Beta strandi188 – 190Combined sources3
Helixi196 – 202Combined sources7
Beta strandi205 – 208Combined sources4
Helixi211 – 213Combined sources3
Turni214 – 216Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MUKNMR-X105-217[»]
ProteinModelPortaliP93830
SMRiP93830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 211PB1PROSITE-ProRule annotationAdd BLAST102

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 18EAR-like (transcriptional repression)5

Domaini

The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.

Sequence similaritiesi

Belongs to the Aux/IAA family.Curated

Phylogenomic databases

eggNOGiENOG410JVDB Eukaryota
ENOG411060M LUCA
HOGENOMiHOG000238261
InParanoidiP93830
KOiK14484
OMAiSCQKSSG
OrthoDBiEOG09360QD8
PhylomeDBiP93830

Family and domain databases

InterProiView protein in InterPro
IPR033389 AUX/IAA_dom
IPR003311 AUX_IAA
IPR000270 PB1_dom
PANTHERiPTHR31734 PTHR31734, 1 hit
PfamiView protein in Pfam
PF02309 AUX_IAA, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit

Sequencei

Sequence statusi: Complete.

P93830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGSVELNLR ETELCLGLPG GDTVAPVTGN KRGFSETVDL KLNLNNEPAN
60 70 80 90 100
KEGSTTHDVV TFDSKEKSAC PKDPAKPPAK AQVVGWPPVR SYRKNVMVSC
110 120 130 140 150
QKSSGGPEAA AFVKVSMDGA PYLRKIDLRM YKSYDELSNA LSNMFSSFTM
160 170 180 190 200
GKHGGEEGMI DFMNERKLMD LVNSWDYVPS YEDKDGDWML VGDVPWPMFV
210 220
DTCKRLRLMK GSDAIGLAPR AMEKCKSRA
Length:229
Mass (Da):25,288
Last modified:January 1, 1998 - v2
Checksum:iECEA39207476581E
GO

Sequence cautioni

The sequence AAM64837 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49073 mRNA Translation: AAB84354.1
AF040631 Genomic DNA Translation: AAC39439.1
AF040632 Genomic DNA Translation: AAC39440.1
AC000104 Genomic DNA Translation: AAB70451.2
CP002684 Genomic DNA Translation: AEE27674.1
AF336916 mRNA Translation: AAG53997.1
AY070094 mRNA Translation: AAL49831.1
AY117183 mRNA Translation: AAM51258.1
AY087284 mRNA Translation: AAM64837.1 Different initiation.
PIRiH86173
RefSeqiNP_171921.1, NM_100306.4
UniGeneiAt.20252

Genome annotation databases

EnsemblPlantsiAT1G04250.1; AT1G04250.1; AT1G04250
GeneIDi839568
GrameneiAT1G04250.1; AT1G04250.1; AT1G04250
KEGGiath:AT1G04250

Similar proteinsi

Entry informationi

Entry nameiIAA17_ARATH
AccessioniPrimary (citable) accession number: P93830
Secondary accession number(s): O49162
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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