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P93665

- DCS1_GOSHI

UniProt

P93665 - DCS1_GOSHI

Protein

(+)-delta-cadinene synthase

Gene

CDN1

Organism
Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.

    Catalytic activityi

    (2E,6E)-farnesyl diphosphate = (+)-delta-cadinene + diphosphate.

    Cofactori

    Binds 3 magnesium ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi307 – 3071Magnesium 1By similarity
    Metal bindingi307 – 3071Magnesium 2By similarity
    Metal bindingi311 – 3111Magnesium 1By similarity
    Metal bindingi311 – 3111Magnesium 2By similarity
    Metal bindingi451 – 4511Magnesium 3By similarity
    Metal bindingi455 – 4551Magnesium 3By similarity

    GO - Molecular functioni

    1. (+)-delta-cadinene synthase activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. terpenoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00213.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    (+)-delta-cadinene synthase (EC:4.2.3.13)
    Short name:
    D-cadinene synthase
    Gene namesi
    Name:CDN1
    OrganismiGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
    Taxonomic identifieri3635 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMalvalesMalvaceaeMalvoideaeGossypium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554(+)-delta-cadinene synthasePRO_0000186443Add
    BLAST

    Expressioni

    Inductioni

    By bacterial infection.

    Structurei

    3D structure databases

    ProteinModelPortaliP93665.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi307 – 3115DDXXD motif

    Domaini

    The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.

    Sequence similaritiesi

    Belongs to the terpene synthase family.Curated

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    1.50.30.10. 1 hit.
    InterProiIPR001906. Terpene_synth_N.
    IPR005630. Terpene_synthase_metal-bd.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF01397. Terpene_synth. 1 hit.
    PF03936. Terpene_synth_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    SSF48576. SSF48576. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P93665-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASQVSQMPS SSPLSSNKDE MRPKADFQPS IWGDFFLNCP DKNIDAETQK    50
    RHQQLKEEVR KMIVAPMANS TLKLAFIDSV QGLGVSYHFT KEIEDELENI 100
    YHNNNDAEND LYTTSLRFRL LREHGFHVSC DVFNKFKDEQ GNFKSSVTSD 150
    VRGLLELYQA SYLRVHGEDI LDEAISFTSN HLSLAVASLD HPLSEEVSHA 200
    LKQSIRRGLP RVEARHYLSV YQDIESHNKV LLEFAKIDFN MVQLLHRKEL 250
    SEISRWWKDL DFQRKLPYAR DRVVEGYFWI SGVYFEPQYS LGRKMLTKVI 300
    AMASIVDDTY DSYATYEELI PYTNAIERWD IKCIDELPEY MKPSYKALLD 350
    VYEEMEQLVA EHGRQYRVEY AKNAMIRLAQ SYLVEARWTL QNYKPSFEEF 400
    KANALPTCGY AMLAITSFVG MGDIVTPETF KWAANDPKII QASTIICRFM 450
    DDVTEHKFKH RREDDCSAIE CYMEEYGVTA QEAYDVFNKH VESAWKDVNQ 500
    GFLKPTEMPT EVLNRSLNLA RVMDVLYREG DGYTYVGKAA KGGITSLLIE 550
    PIAL 554
    Length:554
    Mass (Da):64,020
    Last modified:May 1, 1997 - v1
    Checksum:i8BCC78AD8CA5B816
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88318 mRNA. Translation: AAC12784.1.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Delta-cadinene synthase entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88318 mRNA. Translation: AAC12784.1 .

    3D structure databases

    ProteinModelPortali P93665.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00213 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    1.50.30.10. 1 hit.
    InterProi IPR001906. Terpene_synth_N.
    IPR005630. Terpene_synthase_metal-bd.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF01397. Terpene_synth. 1 hit.
    PF03936. Terpene_synth_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    SSF48576. SSF48576. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence of a (+)-delta-cadinene synthase gene induced in Gossypium hirsutum L. by bacterial infection."
      Davis E.M., Chen Y.-S., Essenberg M., Pierce M.L.
      Plant Gene Register PGR98-040
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Westburn M.
    2. "Purification of (+)-delta-cadinene synthase, a sesquiterpene cyclase from bacteria-inoculated cotton foliar tissue."
      Davis E.M., Tsuji J., Davis G.D., Pierce M.L., Essenberg M.
      Phytochemistry 41:1047-1055(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

    Entry informationi

    Entry nameiDCS1_GOSHI
    AccessioniPrimary (citable) accession number: P93665
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3