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P93665

- DCS1_GOSHI

UniProt

P93665 - DCS1_GOSHI

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Protein

(+)-delta-cadinene synthase

Gene
CDN1
Organism
Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.

Catalytic activityi

(2E,6E)-farnesyl diphosphate = (+)-delta-cadinene + diphosphate.

Cofactori

Binds 3 magnesium ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi307 – 3071Magnesium 1 By similarity
Metal bindingi307 – 3071Magnesium 2 By similarity
Metal bindingi311 – 3111Magnesium 1 By similarity
Metal bindingi311 – 3111Magnesium 2 By similarity
Metal bindingi451 – 4511Magnesium 3 By similarity
Metal bindingi455 – 4551Magnesium 3 By similarity

GO - Molecular functioni

  1. (+)-delta-cadinene synthase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro

GO - Biological processi

  1. terpenoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00213.

Names & Taxonomyi

Protein namesi
Recommended name:
(+)-delta-cadinene synthase (EC:4.2.3.13)
Short name:
D-cadinene synthase
Gene namesi
Name:CDN1
OrganismiGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Taxonomic identifieri3635 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMalvalesMalvaceaeMalvoideaeGossypium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554(+)-delta-cadinene synthasePRO_0000186443Add
BLAST

Expressioni

Inductioni

By bacterial infection.

Structurei

3D structure databases

ProteinModelPortaliP93665.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi307 – 3115DDXXD motif

Domaini

The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.

Sequence similaritiesi

Belongs to the terpene synthase family.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
1.50.30.10. 1 hit.
InterProiIPR001906. Terpene_synth_N.
IPR005630. Terpene_synthase_metal-bd.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF01397. Terpene_synth. 1 hit.
PF03936. Terpene_synth_C. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF48576. SSF48576. 1 hit.

Sequencei

Sequence statusi: Complete.

P93665-1 [UniParc]FASTAAdd to Basket

« Hide

MASQVSQMPS SSPLSSNKDE MRPKADFQPS IWGDFFLNCP DKNIDAETQK    50
RHQQLKEEVR KMIVAPMANS TLKLAFIDSV QGLGVSYHFT KEIEDELENI 100
YHNNNDAEND LYTTSLRFRL LREHGFHVSC DVFNKFKDEQ GNFKSSVTSD 150
VRGLLELYQA SYLRVHGEDI LDEAISFTSN HLSLAVASLD HPLSEEVSHA 200
LKQSIRRGLP RVEARHYLSV YQDIESHNKV LLEFAKIDFN MVQLLHRKEL 250
SEISRWWKDL DFQRKLPYAR DRVVEGYFWI SGVYFEPQYS LGRKMLTKVI 300
AMASIVDDTY DSYATYEELI PYTNAIERWD IKCIDELPEY MKPSYKALLD 350
VYEEMEQLVA EHGRQYRVEY AKNAMIRLAQ SYLVEARWTL QNYKPSFEEF 400
KANALPTCGY AMLAITSFVG MGDIVTPETF KWAANDPKII QASTIICRFM 450
DDVTEHKFKH RREDDCSAIE CYMEEYGVTA QEAYDVFNKH VESAWKDVNQ 500
GFLKPTEMPT EVLNRSLNLA RVMDVLYREG DGYTYVGKAA KGGITSLLIE 550
PIAL 554
Length:554
Mass (Da):64,020
Last modified:May 1, 1997 - v1
Checksum:i8BCC78AD8CA5B816
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U88318 mRNA. Translation: AAC12784.1.

Cross-referencesi

Web resourcesi

Wikipedia

Delta-cadinene synthase entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U88318 mRNA. Translation: AAC12784.1 .

3D structure databases

ProteinModelPortali P93665.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00213 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
1.50.30.10. 1 hit.
InterProi IPR001906. Terpene_synth_N.
IPR005630. Terpene_synthase_metal-bd.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF01397. Terpene_synth. 1 hit.
PF03936. Terpene_synth_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF48576. SSF48576. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "cDNA sequence of a (+)-delta-cadinene synthase gene induced in Gossypium hirsutum L. by bacterial infection."
    Davis E.M., Chen Y.-S., Essenberg M., Pierce M.L.
    Plant Gene Register PGR98-040
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Westburn M.
  2. "Purification of (+)-delta-cadinene synthase, a sesquiterpene cyclase from bacteria-inoculated cotton foliar tissue."
    Davis E.M., Tsuji J., Davis G.D., Pierce M.L., Essenberg M.
    Phytochemistry 41:1047-1055(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

Entry informationi

Entry nameiDCS1_GOSHI
AccessioniPrimary (citable) accession number: P93665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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