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Protein

Lon protease homolog 1, mitochondrial

Gene

LON1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.UniRule annotation1 Publication

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei841UniRule annotation1
Active sitei884UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi464 – 471ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase, Protease, Serine protease
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS16.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog 1, mitochondrial (EC:3.4.21.53UniRule annotation)
Gene namesi
Name:LON1
Ordered Locus Names:At5g26860
ORF Names:F2P16.23
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G26860.
TAIRilocus:2148458. AT5G26860.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 61MitochondrionUniRule annotationAdd BLAST61
ChainiPRO_000002673962 – 940Lon protease homolog 1, mitochondrialAdd BLAST879

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP93655.

PTM databases

iPTMnetiP93655.
SwissPalmiP93655.

Expressioni

Gene expression databases

GenevisibleiP93655. AT.

Interactioni

Subunit structurei

Homohexamer or homoheptamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

BioGridi18019. 6 interactors.
IntActiP93655. 4 interactors.
MINTiMINT-8062621.
STRINGi3702.AT5G26860.1.

Structurei

3D structure databases

ProteinModelPortaliP93655.
SMRiP93655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 307Lon N-terminalPROSITE-ProRule annotationAdd BLAST208
Domaini751 – 935Lon proteolyticPROSITE-ProRule annotationAdd BLAST185

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2004. Eukaryota.
COG0466. LUCA.
HOGENOMiHOG000261409.
InParanoidiP93655.
KOiK08675.
OMAiHISISEN.
OrthoDBiEOG093602OP.
PhylomeDBiP93655.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_03120. lonm_euk. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR008269. Lon_proteolytic.
IPR027065. Lon_Prtase.
IPR003111. Lon_substr-bd.
IPR027503. Lonm_euk.
IPR027417. P-loop_NTPase.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_sf.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PANTHERiPTHR43718. PTHR43718. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiView protein in PROSITE
PS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P93655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLFTSSAS RVHHLTPVSR VVGSSPVESP LFKALSQITG WNRRSTSLGH
60 70 80 90 100
RAFFCSEPTN GEAAAEAETK AVESDSEVSD SKSSSAIVPT NPRPEDCLTV
110 120 130 140 150
LALPVPHRPL FPGFYMPIYV KDPKVLAALQ ESRRRQAPYA GAFLLKDDPS
160 170 180 190 200
ADSSSSTDAE KNINELKGKE LLNRLHEVGT LAQISSIQGD QVILVGHRRL
210 220 230 240 250
RIKEMVSEEP LTVKVDHLKD NPFDMDDDVV KATSFEVIST LRDVLKTSSL
260 270 280 290 300
WRDHVQTYTQ HIGDFTYPRL ADFGAAICGA NRHQAQEVLE ELDVHKRLRL
310 320 330 340 350
TLELMKKEME ISKIQETIAK AIEEKISGEQ RRYLLNEQLK AIKKELGVET
360 370 380 390 400
DDKSALSAKF KERIEPNKEK IPAHVLQVIE EELTKLQLLE ASSSEFNVTR
410 420 430 440 450
NYLDWLTILP WGNYSNENFD VARAQTILDE DHYGLSDVKE RILEFIAVGR
460 470 480 490 500
LRGTSQGKII CLSGPPGVGK TSIGRSIARA LNRKFFRFSV GGLADVAEIK
510 520 530 540 550
GHRRTYVGAM PGKMVQCLKS VGTANPLVLI DEIDKLGRGH AGDPASALLE
560 570 580 590 600
LLDPEQNANF LDHYLDVTID LSKVLFVCTA NVIDMIPNPL LDRMEVISIA
610 620 630 640 650
GYITDEKVHI ARDYLEKTAR GDCGVKPEQV EVSDAALLSL IENYCREAGV
660 670 680 690 700
RNLQKQIEKI YRKIALKLVR EGAVPEEPAV ASDPEEAEIV ADVGESIENH
710 720 730 740 750
TVEENTVSSA EEPKEEAQTE KIAIETVMID ESNLADYVGK PVFHAEKLYE
760 770 780 790 800
QTPVGVVMGL AWTSMGGSTL YIETTVVEEG EGKGGLNITG QLGDVMKESA
810 820 830 840 850
QIAHTVARKI MLEKEPENQF FANSKLHLHV PAGATPKDGP SAGCTMITSL
860 870 880 890 900
LSLATKKPVR KDLAMTGEVT LTGRILPIGG VKEKTIAARR SQIKTIIFPE
910 920 930 940
ANRRDFDELA ENVKEGLNVH FVDDYGKIFE LAFGYDKQED
Length:940
Mass (Da):103,930
Last modified:January 10, 2003 - v2
Checksum:i606E0A8BC9AE5E28
GO

Sequence cautioni

The sequence AAB48000 differs from that shown. Reason: Frameshift at positions 718, 724 and 726.Curated
The sequence AAB61060 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288V → F in AAB48000 (Ref. 1) Curated1
Sequence conflicti500K → Q in AAB48000 (Ref. 1) Curated1
Sequence conflicti679A → S in AAB48000 (Ref. 1) Curated1
Sequence conflicti935 – 936YD → FA in AAB48000 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88087 mRNA. Translation: AAB48000.1. Frameshift.
AF007270 Genomic DNA. Translation: AAB61060.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED93617.1.
AY091049 mRNA. Translation: AAM13870.1.
AY117355 mRNA. Translation: AAM51430.1.
PIRiT01765.
RefSeqiNP_568490.4. NM_122568.4.
UniGeneiAt.10205.

Genome annotation databases

EnsemblPlantsiAT5G26860.1; AT5G26860.1; AT5G26860.
GeneIDi832744.
GrameneiAT5G26860.1; AT5G26860.1; AT5G26860.
KEGGiath:AT5G26860.

Similar proteinsi

Entry informationi

Entry nameiLONM1_ARATH
AccessioniPrimary (citable) accession number: P93655
Secondary accession number(s): O04954, Q8RWX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 10, 2003
Last modified: November 22, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families