P93629 (ADHX_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase class-3
EC=1.1.1.1

Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase
Short name=FALDH
Short name=FDH
Short name=GSH-FDH
EC=1.1.1.-
S-(hydroxymethyl)glutathione dehydrogenase
EC=1.1.1.284

Gene names

Name:

FDH

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH. S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subcellular location	Cytoplasm Potential.
Tissue specificity	Expressed at low levels in the leaves.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	ethanol oxidation Inferred from electronic annotation. Source: InterPro
Molecular function	S-(hydroxymethyl)glutathione dehydrogenase activity Inferred from electronic annotation. Source: EC alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Alcohol dehydrogenase class-3		PRO_0000160772
Sites
	Metal binding	49	1	Zinc 1; catalytic By similarity
	Metal binding	71	1	Zinc 1; catalytic By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	107	1	Zinc 2 By similarity
	Metal binding	115	1	Zinc 2 By similarity
	Metal binding	179	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P93629 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: EABC4BEEDF76B65A	FASTA	381	40,772
	10 20 30 40 50 60 MASPTQGQVI TCKAAVAYEP NKPLVIEDVQ VAPPQAGEVR VKILFTALCH TDHYTWSGKD 70 80 90 100 110 120 PEGLFPCILG HEAAGIVESV GEGVTDVQPG DHVIPCYQAE CKECKFCKSG KTNLCGKVRS 130 140 150 160 170 180 ATGVGVMMND MKSRFSVNGK PIYHFMGTST FSQYTVVHDV SVAKINPQAP LDKVCLLGCG 190 200 210 220 230 240 VPTGLGAVWN TAKVESGSVV AVFGLGTVGL AVAEGAKAAG ASRVIGIDID NKKFDVAKNF 250 260 270 280 290 300 GVTEFVNPKE HDKPIQQVLV DLTDGGVDYS FECIGNVSIM RAALECSDKG WGTSVIVGVA 310 320 330 340 350 360 ASGQEISTRP FQLVTGRVWK GTAFGGFKSR TQVPWLVDKY MKKEIKVDEY ITHNMNLADI 370 380 NDAFHLLHEG GCLRCVLAMQ I

References

[1]	"Maize glutathione-dependent formaldehyde dehydrogenase cDNA: a novel plant gene of detoxification." Fliegmann J., Sandermann H. Jr. Plant Mol. Biol. 34:843-854(1997) [PubMed: 9290637] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Black Mexican Sweet.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11029 mRNA. Translation: CAA71913.1.
PIR	T03289.
RefSeq	NP_001105485.1. NM_001112015.1.
UniGene	Zm.2742.
3D structure databases
ProteinModelPortal	P93629.
SMR	P93629. Positions 8-379.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	542459.
KEGG	zma:542459.
Organism-specific databases
Gramene	P93629.
Phylogenomic databases
GeneTree	EPGT00050000000862.
Family and domain databases
InterPro	IPR014183. ADH_3. IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00121.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 2 hits.
TIGRFAMs	TIGR02818. Adh_III_F_hyde. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADHX_MAIZE

Accession

Primary (citable) accession number: P93629

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1997
Last modified:	December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program