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P93508

- CALR_RICCO

UniProt

P93508 - CALR_RICCO

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Protein
Calreticulin
Gene
N/A
Organism
Ricinus communis (Castor bean)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101Carbohydrate By similarity
Binding sitei112 – 1121Carbohydrate By similarity
Binding sitei129 – 1291Carbohydrate By similarity
Binding sitei136 – 1361Carbohydrate By similarity
Binding sitei319 – 3191Carbohydrate By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium, Lectin, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Calreticulin
OrganismiRicinus communis (Castor bean)
Taxonomic identifieri3988 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeAcalyphoideaeAcalypheaeRicinus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 415395Calreticulin
PRO_0000004195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi106 ↔ 138 By similarity
Glycosylationi152 – 1521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP93508.
SMRiP93508. Positions 207-307.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati192 – 203121-1
Add
BLAST
Repeati211 – 222121-2
Add
BLAST
Repeati228 – 239121-3
Add
BLAST
Repeati246 – 257121-4
Add
BLAST
Repeati261 – 271112-1
Add
BLAST
Repeati275 – 285112-2
Add
BLAST
Repeati289 – 299112-3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni192 – 257664 X approximate repeats
Add
BLAST
Regioni261 – 299393 X approximate repeats
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi412 – 4154Prevents secretion from ER Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi353 – 41058Asp/Glu/Lys-rich
Add
BLAST

Domaini

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.
The interaction with glycans occurs through a binding site in the globular lectin domain By similarity.
The zinc binding sites are localized to the N-domain By similarity.

Sequence similaritiesi

Belongs to the calreticulin family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

KOiK08057.

Family and domain databases

Gene3Di2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFiPIRSF002356. Calreticulin. 1 hit.
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P93508-1 [UniParc]FASTAAdd to Basket

« Hide

MANPKSLSLF LLSLLAIASA EVFFEERFED GWENRWVKSD WKKDENTAGE    50
WNYTSGKWNG DPNDKGIQTS EDYRFYAISA EFPEFSNKDK TLVFQFSVKH 100
EQKLDCGGGY MKLLSSSTDQ KKFGGDTPYS IMFGPDICGY STKKVHAILN 150
YNDTNHLIKK EVPCETDQLT HVYTLVIRPD ATYSILIDNV EKQTGSLYTD 200
WDLLPPKKIK DPEAKKPEDW DEKEYIPDPE DKKPEGYDDI PKEIPDPDAK 250
KPEDWDDEED GEWTAPTIAN PEYKGPWKPK KIKNPNYKGK WKAPMIDNPD 300
FKDDPEIYVY PNLKYVGIEL WQVKSGTLFD NVLICNDPEY AKQLAEETWG 350
KNKDAEKAAF EEAEKKKEEE ESKDDPADSD ADEDDDDADD TEGEDDGESK 400
SDAAEDSAED VHDEL 415
Length:415
Mass (Da):47,522
Last modified:May 1, 1997 - v1
Checksum:iDD5F452E76CC7F8C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U74631 Genomic DNA. Translation: AAB71420.1.
U74630 mRNA. Translation: AAB71419.1.
PIRiT10172.
RefSeqiXP_002512501.1. XM_002512455.1.

Genome annotation databases

GeneIDi8269812.
KEGGircu:RCOM_1434770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U74631 Genomic DNA. Translation: AAB71420.1 .
U74630 mRNA. Translation: AAB71419.1 .
PIRi T10172.
RefSeqi XP_002512501.1. XM_002512455.1.

3D structure databases

ProteinModelPortali P93508.
SMRi P93508. Positions 207-307.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8269812.
KEGGi rcu:RCOM_1434770.

Phylogenomic databases

KOi K08057.

Family and domain databases

Gene3Di 2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProi IPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view ]
PANTHERi PTHR11073. PTHR11073. 1 hit.
Pfami PF00262. Calreticulin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002356. Calreticulin. 1 hit.
PRINTSi PR00626. CALRETICULIN.
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEi PS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the calreticulin gene from Ricinus communis L."
    Coughlan S.J., Hastings C., Winfrey R. Jr.
    Plant Mol. Biol. 34:897-911(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiCALR_RICCO
AccessioniPrimary (citable) accession number: P93508
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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