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P93508 (CALR_RICCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calreticulin
OrganismRicinus communis (Castor bean)
Taxonomic identifier3988 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeAcalyphoideaeAcalypheaeRicinus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen.

Domain

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.

The interaction with glycans occurs through a binding site in the globular lectin domain By similarity.

The zinc binding sites are localized to the N-domain By similarity.

Sequence similarities

Belongs to the calreticulin family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
Lectin
Metal-binding
Zinc
   Molecular functionChaperone
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from direct assay PubMed 11870775. Source: UniProtKB

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 415395Calreticulin
PRO_0000004195

Regions

Repeat192 – 203121-1
Repeat211 – 222121-2
Repeat228 – 239121-3
Repeat246 – 257121-4
Repeat261 – 271112-1
Repeat275 – 285112-2
Repeat289 – 299112-3
Region192 – 257664 X approximate repeats
Region261 – 299393 X approximate repeats
Motif412 – 4154Prevents secretion from ER Potential
Compositional bias353 – 41058Asp/Glu/Lys-rich

Sites

Binding site1101Carbohydrate By similarity
Binding site1121Carbohydrate By similarity
Binding site1291Carbohydrate By similarity
Binding site1361Carbohydrate By similarity
Binding site3191Carbohydrate By similarity

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 138 By similarity

Sequences

Sequence LengthMass (Da)Tools
P93508 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: DD5F452E76CC7F8C

FASTA41547,522
        10         20         30         40         50         60 
MANPKSLSLF LLSLLAIASA EVFFEERFED GWENRWVKSD WKKDENTAGE WNYTSGKWNG 

        70         80         90        100        110        120 
DPNDKGIQTS EDYRFYAISA EFPEFSNKDK TLVFQFSVKH EQKLDCGGGY MKLLSSSTDQ 

       130        140        150        160        170        180 
KKFGGDTPYS IMFGPDICGY STKKVHAILN YNDTNHLIKK EVPCETDQLT HVYTLVIRPD 

       190        200        210        220        230        240 
ATYSILIDNV EKQTGSLYTD WDLLPPKKIK DPEAKKPEDW DEKEYIPDPE DKKPEGYDDI 

       250        260        270        280        290        300 
PKEIPDPDAK KPEDWDDEED GEWTAPTIAN PEYKGPWKPK KIKNPNYKGK WKAPMIDNPD 

       310        320        330        340        350        360 
FKDDPEIYVY PNLKYVGIEL WQVKSGTLFD NVLICNDPEY AKQLAEETWG KNKDAEKAAF 

       370        380        390        400        410 
EEAEKKKEEE ESKDDPADSD ADEDDDDADD TEGEDDGESK SDAAEDSAED VHDEL 

« Hide

References

[1]"Cloning and characterization of the calreticulin gene from Ricinus communis L."
Coughlan S.J., Hastings C., Winfrey R. Jr.
Plant Mol. Biol. 34:897-911(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U74631 Genomic DNA. Translation: AAB71420.1.
U74630 mRNA. Translation: AAB71419.1.
PIRT10172.
RefSeqXP_002512501.1. XM_002512455.1.

3D structure databases

ProteinModelPortalP93508.
SMRP93508. Positions 207-307.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8269812.
KEGGrcu:RCOM_1434770.

Phylogenomic databases

KOK08057.

Family and domain databases

Gene3D2.10.250.10. 1 hit.
2.60.120.200. 1 hit.
InterProIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERPTHR11073. PTHR11073. 1 hit.
PfamPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFPIRSF002356. Calreticulin. 1 hit.
PRINTSPR00626. CALRETICULIN.
SUPFAMSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCALR_RICCO
AccessionPrimary (citable) accession number: P93508
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families