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P93395 (PSB6_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-6

EC=3.4.25.1
Alternative name(s):
Proteasome delta chain
Tobacco cryptogein-induced protein 7
Short name=tcI 7
OrganismNicotiana tabacum (Common tobacco)
Taxonomic identifier4097 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Induction

Up-regulated by elicitins (cryptogein and parasiticein), salicylic acid (SA) and hydrogen peroxide. Ref.2

Sequence similarities

Belongs to the peptidase T1B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 1313Removed in mature form By similarity
PRO_0000026639
Chain14 – 234221Proteasome subunit beta type-6
PRO_0000026640

Sites

Active site141Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P93395 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: B18098EF4B8C3EDC

FASTA23425,183
        10         20         30         40         50         60 
MENTDVDQPH SMGTTIIGVT YNGGVVLGAD SRTSTGMYVA NRASDKITQL TDNVYVCRSG 

        70         80         90        100        110        120 
SAADSQIVSD YVRYFLHQHT IQLGQPATVK VAANLTRLLS YNNKDRLQTG MIIGGWDKYE 

       130        140        150        160        170        180 
GGKIYGIPPG GTVLEQPFAI GGSGSSYLYG FFDQAWKEGM TQEEAEKLVV TAVSLAIARD 

       190        200        210        220        230 
GASGGVVRTV TINKDGATRK FYSGDSLQLW HEELEPVNSL LDVVFASSPV PMVS 

« Hide

References

[1]"Cloning of two plant cDNAs encoding a beta-type proteasome subunit and a transformer-2-like SR-related protein: early induction of the corresponding genes in tobacco cells treated with cryptogein."
Petitot A.S., Blein J.P., Pugin A., Suty L.
Plant Mol. Biol. 35:261-269(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Xanthi.
[2]"Induction of tcI 7, a gene encoding a beta-subunit of proteasome, in tobacco plants treated with elicitins, salicylic acid or hydrogen peroxide."
Etienne P., Petitot A.S., Houot V., Blein J.P., Suty L.
FEBS Lett. 466:213-218(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: REGULATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09505 mRNA. Translation: CAA70699.1.
PIRT03985.

3D structure databases

ProteinModelPortalP93395.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPST01.010.

Proteomic databases

PRIDEP93395.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSPR00141. PROTEASOME.
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB6_TOBAC
AccessionPrimary (citable) accession number: P93395
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries