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P93306

- NDUS2_ARATH

UniProt

P93306 - NDUS2_ARATH

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Protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2
Gene
NAD7, AtMg00510
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme.UniRule annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation
NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  3. quinone binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciARA:ATMG00510-MONOMER.
MetaCyc:ATMG00510-MONOMER.

Protein family/group databases

TCDBi3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Ordered Locus Names:AtMg00510
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Mitochondrion

Organism-specific databases

TAIRiATMG00510.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394NADH dehydrogenase [ubiquinone] iron-sulfur protein 2UniRule annotation
PRO_0000118583Add
BLAST

Proteomic databases

PaxDbiP93306.
PRIDEiP93306.

Expressioni

Gene expression databases

GenevestigatoriP93306.

Interactioni

Subunit structurei

Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

Protein-protein interaction databases

IntActiP93306. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP93306.
SMRiP93306. Positions 12-394.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0649.
HOGENOMiHOG000228264.
KOiK03935.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P93306-1 [UniParc]FASTAAdd to Basket

« Hide

MTTRKRQIKN FTLNFGPQHP AAHGVLRLVL EMNGEVVERA EPHIGLLHRG    50
TEKLIEYKTY LQALPYFDRS DYVSMMAQEH AYSLAVEKLL NCEVPLRAQY 100
IRVLFCEITR ILNHLLALTT HAMDVGALTP FLWAFEEREK LLEFYERVSG 150
ARMHASFIRP GGVAQDLPLG LCRDIDSFTQ QFASRIDELE EMLTGNRIWK 200
QRLVDIGTVT AQQAKDWGFS GVMLRGPGVC WDLRRAAPYD VYDQLDFDVP 250
VGTRGDCYDR YCIRIEEMRQ SLRIIVQCLN QMPSGMIKAD DRKLCPPSRC 300
RMKLSMESSI HHFELYTEGF SVPASSTYTA VEAPKGEFGV FLVSNGSNRP 350
YRCKIRAPGF AHLQGLDFMS KHHMLADVVT IIGTQDIVFG EVDR 394
Length:394
Mass (Da):44,962
Last modified:March 1, 2004 - v2
Checksum:i6DE66B889FAA6BD0
GO

RNA editingi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08501 Genomic DNA. Translation: CAA69735.3. Sequence problems.
AC007729 Genomic DNA. No translation available.
RefSeqiNP_085511.1. NC_001284.2.

Genome annotation databases

EnsemblPlantsiATMG00510.1; ATMG00510.1; ATMG00510.
GeneIDi814592.
KEGGiath:ArthMp043.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08501 Genomic DNA. Translation: CAA69735.3 . Sequence problems.
AC007729 Genomic DNA. No translation available.
RefSeqi NP_085511.1. NC_001284.2.

3D structure databases

ProteinModelPortali P93306.
SMRi P93306. Positions 12-394.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P93306. 4 interactions.

Protein family/group databases

TCDBi 3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbi P93306.
PRIDEi P93306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi ATMG00510.1 ; ATMG00510.1 ; ATMG00510 .
GeneIDi 814592.
KEGGi ath:ArthMp043.

Organism-specific databases

TAIRi ATMG00510.

Phylogenomic databases

eggNOGi COG0649.
HOGENOMi HOG000228264.
KOi K03935.

Enzyme and pathway databases

BioCyci ARA:ATMG00510-MONOMER.
MetaCyc:ATMG00510-MONOMER.

Gene expression databases

Genevestigatori P93306.

Family and domain databases

Gene3Di 1.10.645.10. 1 hit.
HAMAPi MF_01358. NDH1_NuoD.
InterProi IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR01962. NuoD. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
    Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
    Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
    Giege P., Brennicke A.
    Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07709).
    Strain: cv. Columbia.
  4. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiNDUS2_ARATH
AccessioniPrimary (citable) accession number: P93306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 1, 2004
Last modified: June 11, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of the duplicated gene (At2g07709) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi