Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P93306

- NDUS2_ARATH

UniProt

P93306 - NDUS2_ARATH

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

Gene

NAD7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    3. quinone binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciARA:ATMG00510-MONOMER.
    MetaCyc:ATMG00510-MONOMER.

    Protein family/group databases

    TCDBi3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 7
    Gene namesi
    Name:NAD7
    Ordered Locus Names:AtMg00510
    Encoded oniMitochondrion
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Mitochondrion

    Organism-specific databases

    TAIRiATMG00510.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394NADH dehydrogenase [ubiquinone] iron-sulfur protein 2PRO_0000118583Add
    BLAST

    Proteomic databases

    PaxDbiP93306.
    PRIDEiP93306.

    Expressioni

    Gene expression databases

    GenevestigatoriP93306.

    Interactioni

    Subunit structurei

    Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

    Protein-protein interaction databases

    IntActiP93306. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP93306.
    SMRiP93306. Positions 12-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG0649.
    HOGENOMiHOG000228264.
    KOiK03935.

    Family and domain databases

    Gene3Di1.10.645.10. 1 hit.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P93306-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTRKRQIKN FTLNFGPQHP AAHGVLRLVL EMNGEVVERA EPHIGLLHRG    50
    TEKLIEYKTY LQALPYFDRS DYVSMMAQEH AYSLAVEKLL NCEVPLRAQY 100
    IRVLFCEITR ILNHLLALTT HAMDVGALTP FLWAFEEREK LLEFYERVSG 150
    ARMHASFIRP GGVAQDLPLG LCRDIDSFTQ QFASRIDELE EMLTGNRIWK 200
    QRLVDIGTVT AQQAKDWGFS GVMLRGPGVC WDLRRAAPYD VYDQLDFDVP 250
    VGTRGDCYDR YCIRIEEMRQ SLRIIVQCLN QMPSGMIKAD DRKLCPPSRC 300
    RMKLSMESSI HHFELYTEGF SVPASSTYTA VEAPKGEFGV FLVSNGSNRP 350
    YRCKIRAPGF AHLQGLDFMS KHHMLADVVT IIGTQDIVFG EVDR 394
    Length:394
    Mass (Da):44,962
    Last modified:March 1, 2004 - v2
    Checksum:i6DE66B889FAA6BD0
    GO

    RNA editingi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08501 Genomic DNA. Translation: CAA69735.3. Sequence problems.
    AC007729 Genomic DNA. No translation available.
    RefSeqiNP_085511.1. NC_001284.2.

    Genome annotation databases

    EnsemblPlantsiATMG00510.1; ATMG00510.1; ATMG00510.
    GeneIDi814592.
    KEGGiath:ArthMp043.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08501 Genomic DNA. Translation: CAA69735.3 . Sequence problems.
    AC007729 Genomic DNA. No translation available.
    RefSeqi NP_085511.1. NC_001284.2.

    3D structure databases

    ProteinModelPortali P93306.
    SMRi P93306. Positions 12-394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P93306. 4 interactions.

    Protein family/group databases

    TCDBi 3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Proteomic databases

    PaxDbi P93306.
    PRIDEi P93306.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi ATMG00510.1 ; ATMG00510.1 ; ATMG00510 .
    GeneIDi 814592.
    KEGGi ath:ArthMp043.

    Organism-specific databases

    TAIRi ATMG00510.

    Phylogenomic databases

    eggNOGi COG0649.
    HOGENOMi HOG000228264.
    KOi K03935.

    Enzyme and pathway databases

    BioCyci ARA:ATMG00510-MONOMER.
    MetaCyc:ATMG00510-MONOMER.

    Gene expression databases

    Genevestigatori P93306.

    Family and domain databases

    Gene3Di 1.10.645.10. 1 hit.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
      Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
      Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
      Giege P., Brennicke A.
      Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07709).
      Strain: cv. Columbia.
    4. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.

    Entry informationi

    Entry nameiNDUS2_ARATH
    AccessioniPrimary (citable) accession number: P93306
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of the duplicated gene (At2g07709) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3