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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

Gene

NAD7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Miscellaneous

A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of the duplicated gene (At2g07709) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

BioCyciARA:ATMG00510-MONOMER
MetaCyc:ATMG00510-MONOMER
ReactomeiR-ATH-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.3 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Ordered Locus Names:AtMg00510
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Mitochondrion

Organism-specific databases

AraportiATMG00510

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185831 – 394NADH dehydrogenase [ubiquinone] iron-sulfur protein 2Add BLAST394

Proteomic databases

PRIDEiP93306

PTM databases

SwissPalmiP93306

Expressioni

Gene expression databases

ExpressionAtlasiP93306 baseline and differential

Interactioni

Subunit structurei

Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

Protein-protein interaction databases

IntActiP93306, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliP93306
SMRiP93306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Phylogenomic databases

HOGENOMiHOG000228264
InParanoidiP93306
KOiK03935

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01962 NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

P93306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTRKRQIKN FTLNFGPQHP AAHGVLRLVL EMNGEVVERA EPHIGLLHRG
60 70 80 90 100
TEKLIEYKTY LQALPYFDRS DYVSMMAQEH AYSLAVEKLL NCEVPLRAQY
110 120 130 140 150
IRVLFCEITR ILNHLLALTT HAMDVGALTP FLWAFEEREK LLEFYERVSG
160 170 180 190 200
ARMHASFIRP GGVAQDLPLG LCRDIDSFTQ QFASRIDELE EMLTGNRIWK
210 220 230 240 250
QRLVDIGTVT AQQAKDWGFS GVMLRGPGVC WDLRRAAPYD VYDQLDFDVP
260 270 280 290 300
VGTRGDCYDR YCIRIEEMRQ SLRIIVQCLN QMPSGMIKAD DRKLCPPSRC
310 320 330 340 350
RMKLSMESSI HHFELYTEGF SVPASSTYTA VEAPKGEFGV FLVSNGSNRP
360 370 380 390
YRCKIRAPGF AHLQGLDFMS KHHMLADVVT IIGTQDIVFG EVDR
Length:394
Mass (Da):44,962
Last modified:March 1, 2004 - v2
Checksum:i6DE66B889FAA6BD0
GO

RNA editingi

Edited at positions 13, 26, 46, 67, 82, 84, 106, 112, 115, 193, 233, 242, 245, 247, 257, 353, 360, 363, 368 and 375.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08501 Genomic DNA Translation: CAA69735.3 Sequence problems.
AC007729 Genomic DNA No translation available.
RefSeqiNP_085511.1, NC_001284.2

Genome annotation databases

GeneIDi814592
KEGGiath:ArthMp043

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiNDUS2_ARATH
AccessioniPrimary (citable) accession number: P93306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 1, 2004
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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