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Protein

ATP synthase subunit a-1

Gene

ATP6-1

more
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane (By similarity).By similarity

Miscellaneous

The atp6 gene is located on the border of one of the mitochondrial DNA repeats resulting in two identical copies of the mature protein with different propeptide extensions.
A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of this duplicated gene (At2g07741) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit a-1
Alternative name(s):
F-ATPase protein 6
P6-1
Gene namesi
Name:ATP6-1
Ordered Locus Names:AtMg00410Imported
AND
Ordered Locus Names:At2g07741Imported
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componentsi: Chromosome 2, Mitochondrion

Organism-specific databases

AraportiAT2G07741
ATMG00410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000026021 – 133Add BLAST133
ChainiPRO_0000002603134 – 385ATP synthase subunit a-1Add BLAST252

Proteomic databases

PaxDbiP93298

Expressioni

Gene expression databases

GenevisibleiP93298 AT

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

IntActiP93298, 1 interactor
STRINGi3702.ATMG00410.1

Structurei

3D structure databases

ProteinModelPortaliP93298
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase A chain family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4665 Eukaryota
COG0356 LUCA
HOGENOMiHOG000253874
InParanoidiP93298
KOiK02126
OrthoDBiEOG09360MA2
PhylomeDBiP93298

Family and domain databases

Gene3Di1.20.120.220, 1 hit
HAMAPiMF_01393 ATP_synth_a_bact, 1 hit
InterProiView protein in InterPro
IPR000568 ATP_synth_F0_asu
IPR023011 ATP_synth_F0_asu_AS
IPR035908 F0_ATP_A_sf
PfamiView protein in Pfam
PF00119 ATP-synt_A, 1 hit
PRINTSiPR00123 ATPASEA
SUPFAMiSSF81336 SSF81336, 1 hit
TIGRFAMsiTIGR01131 ATP_synt_6_or_A, 1 hit
PROSITEiView protein in PROSITE
PS00449 ATPASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P93298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRIFLFDEN SLNSSSTIDT SSASTIDTSF ASQCTNFSSG QASGTQDTHA
60 70 80 90 100
GIFEDCPGLN PNDERVVELQ CEIREKCEAL TQDPEMGLIL GEALHAESDN
110 120 130 140 150
VPFLQSIADD LTQNGVSGEA FQEALNIVGQ AAASPLDQFE IVPLIPMHIG
160 170 180 190 200
NFYFSFTNSS LFMLLTLSFF LLLIHFVTKK GGGNLVPNAW QSLVELLYDF
210 220 230 240 250
VLNLVKEQIG GLSGNVKQMF FPCILVTFLF LLFCNLQGMI PYSFTVTSHF
260 270 280 290 300
LITLALSFSI FIGITIVGFQ RHGLHFFSFL LPAGVPLPLA PFLVLLELIS
310 320 330 340 350
YCFRALSLGI RLFANMMAGH SLVKILSGFA WTMLCMNDIF YFIGALGPLF
360 370 380
IVLALTGLEL GVAILQAYVF TILICIYLND AINLH
Length:385
Mass (Da):42,342
Last modified:March 1, 2004 - v2
Checksum:iF171DB0D3B0D7129
GO

RNA editingi

Edited at position 159.3 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08501 Genomic DNA Translation: CAA69778.3 Sequence problems.
JF729200 Genomic DNA Translation: AEK01254.1 Sequence problems.
JF729201 Genomic DNA Translation: AEK01282.1 Sequence problems.
JF729202 Genomic DNA Translation: AEK01327.1 Sequence problems.
AC006225 Genomic DNA Translation: AAM15167.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC06126.1 Sequence problems.
EF488888 mRNA Translation: ABS50600.1
EF488889 mRNA Translation: ABS50601.1
RefSeqiNP_085503.1, NC_001284.2
NP_178810.1, NM_126768.1
UniGeneiAt.70276

Genome annotation databases

GeneIDi815413
KEGGiath:ArthMp035
ath:AT2G07741

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiATP61_ARATH
AccessioniPrimary (citable) accession number: P93298
Secondary accession number(s): A7KNE5, F4INF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: June 20, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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