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Protein

ATP synthase subunit a-1

Gene

ATP6-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit a-1
Alternative name(s):
F-ATPase protein 6
P6-1
Gene namesi
Name:ATP6-1
Ordered Locus Names:AtMg00410
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componentsi: Chromosome 2, Mitochondrion

Organism-specific databases

TAIRiATMG00410.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence analysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 133133PRO_0000002602Add
BLAST
Chaini134 – 385252ATP synthase subunit a-1PRO_0000002603Add
BLAST

Proteomic databases

PaxDbiP93298.

Expressioni

Gene expression databases

GenevisibleiP93298. AT.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

IntActiP93298. 1 interaction.
STRINGi3702.ATMG00410.1.

Structurei

3D structure databases

ProteinModelPortaliP93298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase A chain family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4665. Eukaryota.
COG0356. LUCA.
HOGENOMiHOG000253874.
InParanoidiP93298.
KOiK02126.
OrthoDBiEOG09360MA2.
PhylomeDBiP93298.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
HAMAPiMF_01393. ATP_synth_a_bact. 1 hit.
InterProiIPR000568. ATPase_F0-cplx_asu.
IPR023011. ATPase_F0-cplx_asu_AS.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.
TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEiPS00449. ATPASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P93298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRIFLFDEN SLNSSSTIDT SSASTIDTSF ASQCTNFSSG QASGTQDTHA
60 70 80 90 100
GIFEDCPGLN PNDERVVELQ CEIREKCEAL TQDPEMGLIL GEALHAESDN
110 120 130 140 150
VPFLQSIADD LTQNGVSGEA FQEALNIVGQ AAASPLDQFE IVPLIPMHIG
160 170 180 190 200
NFYFSFTNSS LFMLLTLSFF LLLIHFVTKK GGGNLVPNAW QSLVELLYDF
210 220 230 240 250
VLNLVKEQIG GLSGNVKQMF FPCILVTFLF LLFCNLQGMI PYSFTVTSHF
260 270 280 290 300
LITLALSFSI FIGITIVGFQ RHGLHFFSFL LPAGVPLPLA PFLVLLELIS
310 320 330 340 350
YCFRALSLGI RLFANMMAGH SLVKILSGFA WTMLCMNDIF YFIGALGPLF
360 370 380
IVLALTGLEL GVAILQAYVF TILICIYLND AINLH
Length:385
Mass (Da):42,342
Last modified:March 1, 2004 - v2
Checksum:iF171DB0D3B0D7129
GO

RNA editingi

Edited at position 159.3 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08501 Genomic DNA. Translation: CAA69778.3. Sequence problems.
JF729200 Genomic DNA. Translation: AEK01254.1. Sequence problems.
JF729201 Genomic DNA. Translation: AEK01282.1. Sequence problems.
JF729202 Genomic DNA. Translation: AEK01327.1. Sequence problems.
AC006225 Genomic DNA. Translation: AAM15167.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06126.1. Sequence problems.
EF488888 mRNA. Translation: ABS50600.1.
EF488889 mRNA. Translation: ABS50601.1.
RefSeqiNP_085503.1. NC_001284.2.
NP_178810.1. NM_126768.1.
UniGeneiAt.70276.

Genome annotation databases

EnsemblPlantsiAT2G07741.1; AT2G07741.1; AT2G07741.
ATMG00410.1; ATMG00410.1; ATMG00410.
GeneIDi814588.
815413.
GrameneiAT2G07741.1; AT2G07741.1; AT2G07741.
ATMG00410.1; ATMG00410.1; ATMG00410.
KEGGiath:ArthMp035.
ath:AT2G07741.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08501 Genomic DNA. Translation: CAA69778.3. Sequence problems.
JF729200 Genomic DNA. Translation: AEK01254.1. Sequence problems.
JF729201 Genomic DNA. Translation: AEK01282.1. Sequence problems.
JF729202 Genomic DNA. Translation: AEK01327.1. Sequence problems.
AC006225 Genomic DNA. Translation: AAM15167.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06126.1. Sequence problems.
EF488888 mRNA. Translation: ABS50600.1.
EF488889 mRNA. Translation: ABS50601.1.
RefSeqiNP_085503.1. NC_001284.2.
NP_178810.1. NM_126768.1.
UniGeneiAt.70276.

3D structure databases

ProteinModelPortaliP93298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP93298. 1 interaction.
STRINGi3702.ATMG00410.1.

Proteomic databases

PaxDbiP93298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G07741.1; AT2G07741.1; AT2G07741.
ATMG00410.1; ATMG00410.1; ATMG00410.
GeneIDi814588.
815413.
GrameneiAT2G07741.1; AT2G07741.1; AT2G07741.
ATMG00410.1; ATMG00410.1; ATMG00410.
KEGGiath:ArthMp035.
ath:AT2G07741.

Organism-specific databases

TAIRiATMG00410.

Phylogenomic databases

eggNOGiKOG4665. Eukaryota.
COG0356. LUCA.
HOGENOMiHOG000253874.
InParanoidiP93298.
KOiK02126.
OrthoDBiEOG09360MA2.
PhylomeDBiP93298.

Miscellaneous databases

PROiP93298.

Gene expression databases

GenevisibleiP93298. AT.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
HAMAPiMF_01393. ATP_synth_a_bact. 1 hit.
InterProiIPR000568. ATPase_F0-cplx_asu.
IPR023011. ATPase_F0-cplx_asu_AS.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.
TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEiPS00449. ATPASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP61_ARATH
AccessioniPrimary (citable) accession number: P93298
Secondary accession number(s): A7KNE5, F4INF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The atp6 gene is located on the border of one of the mitochondrial DNA repeats resulting in two identical copies of the mature protein with different propeptide extensions.
A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of this duplicated gene (At2g07741) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.