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P93285

- COX2_ARATH

UniProt

P93285 - COX2_ARATH

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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Copper ABy similarity
Metal bindingi222 – 2221Copper ABy similarity
Metal bindingi226 – 2261Copper ABy similarity
Metal bindingi230 – 2301Copper ABy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:ATMG00160-MONOMER.
MetaCyc:ATMG00160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COXII
Ordered Locus Names:AtMg00160
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Mitochondrion

Organism-specific databases

TAIRiATMG00160.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Cytochrome c oxidase subunit 2PRO_0000183502Add
BLAST

Proteomic databases

PaxDbiP93285.
PRIDEiP93285.

Expressioni

Gene expression databases

GenevestigatoriP93285.

Interactioni

Protein-protein interaction databases

BioGridi7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP93285.
SMRiP93285. Positions 17-253.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini63 – 8624Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini108 – 260153Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000264988.
InParanoidiP93285.
KOiK02261.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P93285-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVLKWLFFT ISPCDAAEPW QLGFQDAATP IMQGIIDLHH DIFFFLILIL
60 70 80 90 100
VFVLWILVRA LWHFHYKKNA IPQRIVHGTT IEILWTIFPS IILMFIAIPS
110 120 130 140 150
FALLYSMDEV VVDPAITIKA IGHQWYWTYE YSDYNSSDEQ SLTFDSYMIP
160 170 180 190 200
EEDLELGQLR LLEVDNRVVV PAKTHLRIIV TSADVLHSWA VPSLGVKCDA
210 220 230 240 250
VPGRLNQISI LVQREGVYYG QCSEICGTNH AFMSIVVEAV SRKDYGSWVS
260
NQLIPQTGEA
Length:260
Mass (Da):29,674
Last modified:March 1, 2004 - v2
Checksum:i7D2D75A093973985
GO

RNA editingi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08501 Genomic DNA. Translation: CAA69761.3. Sequence problems.
RefSeqiNP_085487.1. NC_001284.2.

Genome annotation databases

EnsemblPlantsiATMG00160.1; ATMG00160.1; ATMG00160.
GeneIDi814573.
KEGGiath:ArthMp015.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08501 Genomic DNA. Translation: CAA69761.3 . Sequence problems.
RefSeqi NP_085487.1. NC_001284.2.

3D structure databases

ProteinModelPortali P93285.
SMRi P93285. Positions 17-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 7. 1 interaction.

Proteomic databases

PaxDbi P93285.
PRIDEi P93285.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi ATMG00160.1 ; ATMG00160.1 ; ATMG00160 .
GeneIDi 814573.
KEGGi ath:ArthMp015.

Organism-specific databases

TAIRi ATMG00160.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000264988.
InParanoidi P93285.
KOi K02261.

Enzyme and pathway databases

BioCyci ARA:ATMG00160-MONOMER.
MetaCyc:ATMG00160-MONOMER.

Gene expression databases

Genevestigatori P93285.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
    Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
    Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
    Giege P., Brennicke A.
    Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
  3. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiCOX2_ARATH
AccessioniPrimary (citable) accession number: P93285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3