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P93285

- COX2_ARATH

UniProt

P93285 - COX2_ARATH

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi187 – 1871Copper ABy similarity
    Metal bindingi222 – 2221Copper ABy similarity
    Metal bindingi226 – 2261Copper ABy similarity
    Metal bindingi230 – 2301Copper ABy similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:ATMG00160-MONOMER.
    MetaCyc:ATMG00160-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Synonyms:COXII
    Ordered Locus Names:AtMg00160
    Encoded oniMitochondrion
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Mitochondrion

    Organism-specific databases

    TAIRiATMG00160.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Cytochrome c oxidase subunit 2PRO_0000183502Add
    BLAST

    Proteomic databases

    PaxDbiP93285.
    PRIDEiP93285.

    Expressioni

    Gene expression databases

    GenevestigatoriP93285.

    Interactioni

    Protein-protein interaction databases

    BioGridi7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP93285.
    SMRiP93285. Positions 17-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini63 – 8624Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini108 – 260153Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000264988.
    KOiK02261.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P93285-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVLKWLFFT ISPCDAAEPW QLGFQDAATP IMQGIIDLHH DIFFFLILIL    50
    VFVLWILVRA LWHFHYKKNA IPQRIVHGTT IEILWTIFPS IILMFIAIPS 100
    FALLYSMDEV VVDPAITIKA IGHQWYWTYE YSDYNSSDEQ SLTFDSYMIP 150
    EEDLELGQLR LLEVDNRVVV PAKTHLRIIV TSADVLHSWA VPSLGVKCDA 200
    VPGRLNQISI LVQREGVYYG QCSEICGTNH AFMSIVVEAV SRKDYGSWVS 250
    NQLIPQTGEA 260
    Length:260
    Mass (Da):29,674
    Last modified:March 1, 2004 - v2
    Checksum:i7D2D75A093973985
    GO

    RNA editingi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08501 Genomic DNA. Translation: CAA69761.3. Sequence problems.
    RefSeqiNP_085487.1. NC_001284.2.

    Genome annotation databases

    EnsemblPlantsiATMG00160.1; ATMG00160.1; ATMG00160.
    GeneIDi814573.
    KEGGiath:ArthMp015.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08501 Genomic DNA. Translation: CAA69761.3 . Sequence problems.
    RefSeqi NP_085487.1. NC_001284.2.

    3D structure databases

    ProteinModelPortali P93285.
    SMRi P93285. Positions 17-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 7. 1 interaction.

    Proteomic databases

    PaxDbi P93285.
    PRIDEi P93285.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi ATMG00160.1 ; ATMG00160.1 ; ATMG00160 .
    GeneIDi 814573.
    KEGGi ath:ArthMp015.

    Organism-specific databases

    TAIRi ATMG00160.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000264988.
    KOi K02261.

    Enzyme and pathway databases

    BioCyci ARA:ATMG00160-MONOMER.
    MetaCyc:ATMG00160-MONOMER.

    Gene expression databases

    Genevestigatori P93285.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
      Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
      Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
      Giege P., Brennicke A.
      Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
    3. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.

    Entry informationi

    Entry nameiCOX2_ARATH
    AccessioniPrimary (citable) accession number: P93285
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3