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Protein

Receptor-like protein kinase

Gene

INRPK1

Organism
Ipomoea nil (Japanese morning glory) (Pharbitis nil)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Possible role in short-day photoperiod floral induction.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei845ATPPROSITE-ProRule annotation1
Active sitei942Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi822 – 830ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-like protein kinase (EC:2.7.11.1)
Gene namesi
Name:INRPK1
OrganismiIpomoea nil (Japanese morning glory) (Pharbitis nil)Imported
Taxonomic identifieri35883 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 764ExtracellularSequence analysisAdd BLAST744
Transmembranei765 – 785HelicalSequence analysisAdd BLAST21
Topological domaini786 – 1109CytoplasmicSequence analysisAdd BLAST324

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002438221 – 1109Receptor-like protein kinaseAdd BLAST1089

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Curated1
Glycosylationi74N-linked (GlcNAc...)Curated1
Glycosylationi114N-linked (GlcNAc...)Curated1
Glycosylationi144N-linked (GlcNAc...)Curated1
Glycosylationi177N-linked (GlcNAc...)Curated1
Glycosylationi186N-linked (GlcNAc...)Curated1
Glycosylationi210N-linked (GlcNAc...)Curated1
Glycosylationi245N-linked (GlcNAc...)Curated1
Glycosylationi282N-linked (GlcNAc...)Curated1
Glycosylationi367N-linked (GlcNAc...)Curated1
Glycosylationi391N-linked (GlcNAc...)Curated1
Glycosylationi427N-linked (GlcNAc...)Curated1
Glycosylationi510N-linked (GlcNAc...)Curated1
Glycosylationi524N-linked (GlcNAc...)Curated1
Glycosylationi553N-linked (GlcNAc...)Curated1
Glycosylationi584N-linked (GlcNAc...)Curated1
Glycosylationi648N-linked (GlcNAc...)Curated1
Glycosylationi677N-linked (GlcNAc...)Curated1
Glycosylationi695N-linked (GlcNAc...)Curated1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

INRPK1 and INRPK1b are expressed in leaves, cotyledons, shoot tips and roots from induced and vegetative plants. The highest concentrations of INRPK1 are found in vegetative roots, and the lowest concentrations in vegetative cotyledons. INRPK1b is more abundant in roots than other tissues. INRPK1a is expressed in vegetative roots. INRPK1c is expressed in cotyledons.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP93194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati69 – 92LRR 1Add BLAST24
Repeati93 – 115LRR 2Add BLAST23
Repeati117 – 140LRR 3Add BLAST24
Repeati141 – 162LRR 4CuratedAdd BLAST22
Repeati165 – 187LRR 5Add BLAST23
Repeati189 – 209LRR 6Add BLAST21
Repeati213 – 236LRR 7Add BLAST24
Repeati237 – 258LRR 8Add BLAST22
Repeati261 – 284LRR 9Add BLAST24
Repeati309 – 331LRR 10Add BLAST23
Repeati333 – 355LRR 11Add BLAST23
Repeati357 – 378LRR 12Add BLAST22
Repeati381 – 404LRR 13Add BLAST24
Repeati405 – 427LRR 14Add BLAST23
Repeati429 – 451LRR 15Add BLAST23
Repeati453 – 476LRR 16Add BLAST24
Repeati477 – 499LRR 17Add BLAST23
Repeati500 – 523LRR 18Add BLAST24
Repeati524 – 546LRR 19Add BLAST23
Repeati548 – 569LRR 20Add BLAST22
Repeati572 – 595LRR 21Add BLAST24
Repeati596 – 618LRR 22Add BLAST23
Repeati620 – 642LRR 23Add BLAST23
Repeati643 – 666LRR 24Add BLAST24
Repeati667 – 689LRR 25Add BLAST23
Repeati690 – 710LRR 26Add BLAST21
Domaini816 – 1096Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST281
Repeati827 – 850LRR 27CuratedAdd BLAST24
Repeati958 – 981LRR 28CuratedAdd BLAST24

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 28 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform INRPK11 Publication (identifier: P93194-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVAVNTFLL FLCSTSSIYA AFALNSDGAA LLSLTRHWTS IPSDITQSWN
60 70 80 90 100
ASDSTPCSWL GVECDRRQFV DTLNLSSYGI SGEFGPEISH LKHLKKVVLS
110 120 130 140 150
GNGFFGSIPS QLGNCSLLEH IDLSSNSFTG NIPDTLGALQ NLRNLSLFFN
160 170 180 190 200
SLIGPFPESL LSIPHLETVY FTGNGLNGSI PSNIGNMSEL TTLWLDDNQF
210 220 230 240 250
SGPVPSSLGN ITTLQELYLN DNNLVGTLPV TLNNLENLVY LDVRNNSLVG
260 270 280 290 300
AIPLDFVSCK QIDTISLSNN QFTGGLPPGL GNCTSLREFG AFSCALSGPI
310 320 330 340 350
PSCFGQLTKL DTLYLAGNHF SGRIPPELGK CKSMIDLQLQ QNQLEGEIPG
360 370 380 390 400
ELGMLSQLQY LHLYTNNLSG EVPLSIWKIQ SLQSLQLYQN NLSGELPVDM
410 420 430 440 450
TELKQLVSLA LYENHFTGVI PQDLGANSSL EVLDLTRNMF TGHIPPNLCS
460 470 480 490 500
QKKLKRLLLG YNYLEGSVPS DLGGCSTLER LILEENNLRG GLPDFVEKQN
510 520 530 540 550
LLFFDLSGNN FTGPIPPSLG NLKNVTAIYL SSNQLSGSIP PELGSLVKLE
560 570 580 590 600
HLNLSHNILK GILPSELSNC HKLSELDASH NLLNGSIPST LGSLTELTKL
610 620 630 640 650
SLGENSFSGG IPTSLFQSNK LLNLQLGGNL LAGDIPPVGA LQALRSLNLS
660 670 680 690 700
SNKLNGQLPI DLGKLKMLEE LDVSHNNLSG TLRVLSTIQS LTFINISHNL
710 720 730 740 750
FSGPVPPSLT KFLNSSPTSF SGNSDLCINC PADGLACPES SILRPCNMQS
760 770 780 790 800
NTGKGGLSTL GIAMIVLGAL LFIICLFLFS AFLFLHCKKS VQEIAISAQE
810 820 830 840 850
GDGSLLNKVL EATENLNDKY VIGKGAHGTI YKATLSPDKV YAVKKLVFTG
860 870 880 890 900
IKNGSVSMVR EIETIGKVRH RNLIKLEEFW LRKEYGLILY TYMENGSLHD
910 920 930 940 950
ILHETNPPKP LDWSTRHNIA VGTAHGLAYL HFDCDPAIVH RDIKPMNILL
960 970 980 990 1000
DSDLEPHISD FGIAKLLDQS ATSIPSNTVQ GTIGYMAPEN AFTTVKSRES
1010 1020 1030 1040 1050
DVYSYGVVLL ELITRKKALD PSFNGETDIV GWVRSVWTQT GEIQKIVDPS
1060 1070 1080 1090 1100
LLDELIDSSV MEQVTEALSL ALRCAEKEVD KRPTMRDVVK QLTRWSIRSY

SSSVRNKSK
Length:1,109
Mass (Da):120,765
Last modified:October 1, 2001 - v2
Checksum:iB7B7C50A4A0FAF29
GO
Isoform INRPK1a1 Publication (identifier: P93194-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-591: Missing.

Show »
Length:647
Mass (Da):70,618
Checksum:i7185B636B994B5F4
GO
Isoform INRPK1b1 Publication (identifier: P93194-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-155: GNIPDTLGALQNLRNLSLFFNSLIGP → ARWKFTSWRYSTSGSFAGTEVIKFEQ
     156-1109: Missing.

Show »
Length:155
Mass (Da):17,031
Checksum:i74886A332673A7D5
GO
Isoform INRPK1c (identifier: P93194-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-666: Missing.

Note: Produced by alternative initiation at Met-667 of isoform INRPK1.
Show »
Length:443
Mass (Da):48,918
Checksum:i00CD8EFD40FE5D34
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188571 – 666Missing in isoform INRPK1c. CuratedAdd BLAST666
Alternative sequenceiVSP_050676130 – 591Missing in isoform INRPK1a. 1 PublicationAdd BLAST462
Alternative sequenceiVSP_050677130 – 155GNIPD…SLIGP → ARWKFTSWRYSTSGSFAGTE VIKFEQ in isoform INRPK1b. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_050678156 – 1109Missing in isoform INRPK1b. 1 PublicationAdd BLAST954

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77888 Genomic DNA. Translation: AAB36558.2.
U77888 Genomic DNA. Translation: AAG52992.2.
U77888 Genomic DNA. Translation: AAG52993.2.
U77888 Genomic DNA. Translation: AAG52994.1.
PIRiT18536.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77888 Genomic DNA. Translation: AAB36558.2.
U77888 Genomic DNA. Translation: AAG52992.2.
U77888 Genomic DNA. Translation: AAG52993.2.
U77888 Genomic DNA. Translation: AAG52994.1.
PIRiT18536.

3D structure databases

ProteinModelPortaliP93194.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPK1_IPONI
AccessioniPrimary (citable) accession number: P93194
Secondary accession number(s): Q9AVV0, Q9AVV1, Q9AVV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2001
Last modified: October 5, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.