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Protein

Receptor-like protein kinase

Gene

INRPK1

Organism
Ipomoea nil (Japanese morning glory) (Pharbitis nil)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Possible role in short-day photoperiod floral induction.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei845 – 8451ATPPROSITE-ProRule annotation
Active sitei942 – 9421Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi822 – 8309ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • protein phosphorylation Source: UniProtKB
  • signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-like protein kinase (EC:2.7.11.1)
Gene namesi
Name:INRPK1
OrganismiIpomoea nil (Japanese morning glory) (Pharbitis nil)Imported
Taxonomic identifieri35883 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesConvolvulaceaeIpomoeeaeIpomoea

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 764744ExtracellularSequence analysisAdd
BLAST
Transmembranei765 – 78521HelicalSequence analysisAdd
BLAST
Topological domaini786 – 1109324CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 11091089Receptor-like protein kinasePRO_0000024382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Curated
Glycosylationi74 – 741N-linked (GlcNAc...)Curated
Glycosylationi114 – 1141N-linked (GlcNAc...)Curated
Glycosylationi144 – 1441N-linked (GlcNAc...)Curated
Glycosylationi177 – 1771N-linked (GlcNAc...)Curated
Glycosylationi186 – 1861N-linked (GlcNAc...)Curated
Glycosylationi210 – 2101N-linked (GlcNAc...)Curated
Glycosylationi245 – 2451N-linked (GlcNAc...)Curated
Glycosylationi282 – 2821N-linked (GlcNAc...)Curated
Glycosylationi367 – 3671N-linked (GlcNAc...)Curated
Glycosylationi391 – 3911N-linked (GlcNAc...)Curated
Glycosylationi427 – 4271N-linked (GlcNAc...)Curated
Glycosylationi510 – 5101N-linked (GlcNAc...)Curated
Glycosylationi524 – 5241N-linked (GlcNAc...)Curated
Glycosylationi553 – 5531N-linked (GlcNAc...)Curated
Glycosylationi584 – 5841N-linked (GlcNAc...)Curated
Glycosylationi648 – 6481N-linked (GlcNAc...)Curated
Glycosylationi677 – 6771N-linked (GlcNAc...)Curated
Glycosylationi695 – 6951N-linked (GlcNAc...)Curated

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

INRPK1 and INRPK1b are expressed in leaves, cotyledons, shoot tips and roots from induced and vegetative plants. The highest concentrations of INRPK1 are found in vegetative roots, and the lowest concentrations in vegetative cotyledons. INRPK1b is more abundant in roots than other tissues. INRPK1a is expressed in vegetative roots. INRPK1c is expressed in cotyledons.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP93194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati69 – 9224LRR 1Add
BLAST
Repeati93 – 11523LRR 2Add
BLAST
Repeati117 – 14024LRR 3Add
BLAST
Repeati141 – 16222LRR 4CuratedAdd
BLAST
Repeati165 – 18723LRR 5Add
BLAST
Repeati189 – 20921LRR 6Add
BLAST
Repeati213 – 23624LRR 7Add
BLAST
Repeati237 – 25822LRR 8Add
BLAST
Repeati261 – 28424LRR 9Add
BLAST
Repeati309 – 33123LRR 10Add
BLAST
Repeati333 – 35523LRR 11Add
BLAST
Repeati357 – 37822LRR 12Add
BLAST
Repeati381 – 40424LRR 13Add
BLAST
Repeati405 – 42723LRR 14Add
BLAST
Repeati429 – 45123LRR 15Add
BLAST
Repeati453 – 47624LRR 16Add
BLAST
Repeati477 – 49923LRR 17Add
BLAST
Repeati500 – 52324LRR 18Add
BLAST
Repeati524 – 54623LRR 19Add
BLAST
Repeati548 – 56922LRR 20Add
BLAST
Repeati572 – 59524LRR 21Add
BLAST
Repeati596 – 61823LRR 22Add
BLAST
Repeati620 – 64223LRR 23Add
BLAST
Repeati643 – 66624LRR 24Add
BLAST
Repeati667 – 68923LRR 25Add
BLAST
Repeati690 – 71021LRR 26Add
BLAST
Domaini816 – 1096281Protein kinasePROSITE-ProRule annotationCuratedAdd
BLAST
Repeati827 – 85024LRR 27CuratedAdd
BLAST
Repeati958 – 98124LRR 28CuratedAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 28 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 3 hits.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform INRPK11 Publication (identifier: P93194-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVAVNTFLL FLCSTSSIYA AFALNSDGAA LLSLTRHWTS IPSDITQSWN
60 70 80 90 100
ASDSTPCSWL GVECDRRQFV DTLNLSSYGI SGEFGPEISH LKHLKKVVLS
110 120 130 140 150
GNGFFGSIPS QLGNCSLLEH IDLSSNSFTG NIPDTLGALQ NLRNLSLFFN
160 170 180 190 200
SLIGPFPESL LSIPHLETVY FTGNGLNGSI PSNIGNMSEL TTLWLDDNQF
210 220 230 240 250
SGPVPSSLGN ITTLQELYLN DNNLVGTLPV TLNNLENLVY LDVRNNSLVG
260 270 280 290 300
AIPLDFVSCK QIDTISLSNN QFTGGLPPGL GNCTSLREFG AFSCALSGPI
310 320 330 340 350
PSCFGQLTKL DTLYLAGNHF SGRIPPELGK CKSMIDLQLQ QNQLEGEIPG
360 370 380 390 400
ELGMLSQLQY LHLYTNNLSG EVPLSIWKIQ SLQSLQLYQN NLSGELPVDM
410 420 430 440 450
TELKQLVSLA LYENHFTGVI PQDLGANSSL EVLDLTRNMF TGHIPPNLCS
460 470 480 490 500
QKKLKRLLLG YNYLEGSVPS DLGGCSTLER LILEENNLRG GLPDFVEKQN
510 520 530 540 550
LLFFDLSGNN FTGPIPPSLG NLKNVTAIYL SSNQLSGSIP PELGSLVKLE
560 570 580 590 600
HLNLSHNILK GILPSELSNC HKLSELDASH NLLNGSIPST LGSLTELTKL
610 620 630 640 650
SLGENSFSGG IPTSLFQSNK LLNLQLGGNL LAGDIPPVGA LQALRSLNLS
660 670 680 690 700
SNKLNGQLPI DLGKLKMLEE LDVSHNNLSG TLRVLSTIQS LTFINISHNL
710 720 730 740 750
FSGPVPPSLT KFLNSSPTSF SGNSDLCINC PADGLACPES SILRPCNMQS
760 770 780 790 800
NTGKGGLSTL GIAMIVLGAL LFIICLFLFS AFLFLHCKKS VQEIAISAQE
810 820 830 840 850
GDGSLLNKVL EATENLNDKY VIGKGAHGTI YKATLSPDKV YAVKKLVFTG
860 870 880 890 900
IKNGSVSMVR EIETIGKVRH RNLIKLEEFW LRKEYGLILY TYMENGSLHD
910 920 930 940 950
ILHETNPPKP LDWSTRHNIA VGTAHGLAYL HFDCDPAIVH RDIKPMNILL
960 970 980 990 1000
DSDLEPHISD FGIAKLLDQS ATSIPSNTVQ GTIGYMAPEN AFTTVKSRES
1010 1020 1030 1040 1050
DVYSYGVVLL ELITRKKALD PSFNGETDIV GWVRSVWTQT GEIQKIVDPS
1060 1070 1080 1090 1100
LLDELIDSSV MEQVTEALSL ALRCAEKEVD KRPTMRDVVK QLTRWSIRSY

SSSVRNKSK
Length:1,109
Mass (Da):120,765
Last modified:October 1, 2001 - v2
Checksum:iB7B7C50A4A0FAF29
GO
Isoform INRPK1a1 Publication (identifier: P93194-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-591: Missing.

Show »
Length:647
Mass (Da):70,618
Checksum:i7185B636B994B5F4
GO
Isoform INRPK1b1 Publication (identifier: P93194-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-155: GNIPDTLGALQNLRNLSLFFNSLIGP → ARWKFTSWRYSTSGSFAGTEVIKFEQ
     156-1109: Missing.

Show »
Length:155
Mass (Da):17,031
Checksum:i74886A332673A7D5
GO
Isoform INRPK1c (identifier: P93194-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-666: Missing.

Note: Produced by alternative initiation at Met-667 of isoform INRPK1.
Show »
Length:443
Mass (Da):48,918
Checksum:i00CD8EFD40FE5D34
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 666666Missing in isoform INRPK1c. CuratedVSP_018857Add
BLAST
Alternative sequencei130 – 591462Missing in isoform INRPK1a. 1 PublicationVSP_050676Add
BLAST
Alternative sequencei130 – 15526GNIPD…SLIGP → ARWKFTSWRYSTSGSFAGTE VIKFEQ in isoform INRPK1b. 1 PublicationVSP_050677Add
BLAST
Alternative sequencei156 – 1109954Missing in isoform INRPK1b. 1 PublicationVSP_050678Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77888 Genomic DNA. Translation: AAB36558.2.
U77888 Genomic DNA. Translation: AAG52992.2.
U77888 Genomic DNA. Translation: AAG52993.2.
U77888 Genomic DNA. Translation: AAG52994.1.
PIRiT18536.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77888 Genomic DNA. Translation: AAB36558.2.
U77888 Genomic DNA. Translation: AAG52992.2.
U77888 Genomic DNA. Translation: AAG52993.2.
U77888 Genomic DNA. Translation: AAG52994.1.
PIRiT18536.

3D structure databases

ProteinModelPortaliP93194.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 3 hits.
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alternative transcript initiation and novel post-transcriptional processing of a leucine-rich repeat receptor-like protein kinase gene that responds to short-day photoperiodic floral induction in morning glory (Ipomoea nil)."
    Bassett C.L., Nickerson M.L., Cohen R.A., Rajeevan M.S.
    Plant Mol. Biol. 43:43-58(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS INRPK1; INRPK1A; INRPK1B AND INRPK1C), TISSUE SPECIFICITY.
    Strain: cv. VioletImported.
    Tissue: LeafImported.

Entry informationi

Entry nameiRPK1_IPONI
AccessioniPrimary (citable) accession number: P93194
Secondary accession number(s): Q9AVV0, Q9AVV1, Q9AVV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2001
Last modified: May 11, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.